Introduction
LTP as a cellular model for brain plasticity
NMDA receptor and LTP
NMDA receptor independent LTP
Composition of NMDA receptors
Contribution of NR2B-containing NMDA receptors to synaptic LTP
Brain region
|
Pharmacological inhibitors or genetic manipulation
|
Induction protocol
|
Effects on LTP
|
Reference
|
---|---|---|---|---|
ACC
| NR2B antagonist | Pairing protocol | Reduced | Zhao et al., 2005 |
Spike-timing protocol | Blocked | |||
Theta burst stimulation (TBS) | blocked | |||
Perirhinal cortex
| NR2B antagonist | High frequency stimulation (HFS) | No effect | Massey et al., 2004 |
Visual cortex
| NR2B antagonist | Pairing protocol | blocked | Yoshimura et al., 2003 |
Hippocampal CA1
| NR2B overexpression | HFS or repetitive stimulation | Enhanced | Tang et al., 1999 |
HFS | No effect | Liu et al., 2004 | ||
NR2B antagonist | Pairing protocol | No effect | ||
HFS | Reduced | Berberich et al., 2007 | ||
Pairing protocol | Blocked | |||
HFS | No effect | Zhang et al., 2008 | ||
Pairing protocol | No effect | |||
Spike-timing protocol | blocked | |||
Amygdala
| NR2B antagonist | Pairing protocol | Reduced | Miwa et al., 2008 |
Spinal dorsal horn
| ND | ND | ND |
Requirement of NMDA receptor NR2B subunit in behavioral learning
NMDA NR2B receptor does not undergo potentiation in memory storage
Brain function
|
Drug or manipulation
|
Brain regions
|
Effects
|
Reference
|
---|---|---|---|---|
Spatial memory (Morris water maze)
| NR2B overexpression | Forebrain | Enhanced fear memory | Tang et al., 1999 |
NR2B antagonist | Systemic injection | No effect | Guscott et al., 2003 | |
Fear memory
| NR2B overexpression | Forebrain | Enhanced fear memory | Tang et al., 1999 |
NR2B antagonist | Amygdala | Blocked acquisition | Rodrigues et al., 2001 | |
No effect on expression of fear | ||||
NR2B antagonist | Amygdala | Inhibit fear conditioning without effect on fear expression | Walker and Davis, 2008 | |
Chronic pain
| NR2B overexpression | Forebrain | Enhancing chronic pain | Wei et al., 2002 |
NR2B antagonist | ACC | Inhibiting chronic pain | Wu et al., 2005 |