High dose radiation exposure (5 + Gy)
Average age at diagnosis | Dose (controls) | ERR/Gy | |||||||
---|---|---|---|---|---|---|---|---|---|
Reference
|
2nd cancer
|
1st cancer
|
Cases
|
Controls
|
1st cancer
|
Sarcoma
|
Average
|
Max
|
(& 95% Cl)
|
Radiotherapy in Childhood
| |||||||||
Tucker 1987 [4] | Bone Sarcoma | Childhood | 68 | 209 | 7 yrs | na | 27 Gy | 60+ Gy | 0.06 (0.01–0.20)* |
Hawkins 1996 [5] | Bone Sarcoma | Childhood | 50 | 168 | ns | na | 5 Gy | 50+ Gy | 0.16 (0.07–0.37)* |
Le Vu 1998 [6] | Osteosarcoma | Childhood | 32 | 160 | 6 yrs | 15 yrs | 8 Gy | 83 Gy | 1.4 (0.1–21.8) |
Wong 1997 [7] | Soft tissue sarcoma | Retinoblastoma | 31 | 89 | <2 yrs | 15 yrs | 11 Gy | 112 Gy | 0.17 (0.025–16.3) |
Menu-Branthomme 2004 [8] | Soft tissue sarcoma | Childhood | 23 | 111 | 8 yrs | 21 yrs | 12 Gy | 50 Gy | na |
Jenkinson 2007 [9] | Soft tissue sarcoma | Childhood | 53 | 179 | 7 yrs | 17 yrs | 5 Gy | 30+ Gy | na |
Radiotherapy in Adulthood
| |||||||||
Boice 1988 [10] | Bone Sarcoma | Cervix | 15 | 155 | 50 yrs | 67 yrs | 22 Gy | 10+ Gy | 0.02 (−0.03–0.21)* |
Boice 1988 [10] | Soft tissue sarcoma | Cervix | 46 | 598 | 50 yrs | 67 yrs | 7 Gy | 10+ Gy | −0.05 (−0.11–0.13)* |
Rubino 2005 [11] | All sarcomas | Breast | 14 | 98 | 55 yrs | 62 yrs | 19 Gy | 80 Gy | 0.05 (<0-1.18) |
Childhood radiotherapy
Adulthood radiotherapy
Bone sarcoma | Soft tissue sarcoma | |||||||
---|---|---|---|---|---|---|---|---|
Time since 1st | Radiotherapy | No radiotherapy | Radiotherapy | No radiotherapy | ||||
Cancer diagnosis | Obs | SIR | Obs | SIR | Obs | SIR | Obs | SIR |
1-4 yrs | 34 | 1.49* | 77 | 1.32* | 135 | 1.22* | 311 | 1.15* |
5-9 yrs | 43 | 2.74* | 56 | 1.24 | 185 | 2.22* | 271 | 1.21* |
10-14 yrs | 23 | 3.23* | 34 | 1.31 | 78 | 2.04* | 141 | 1.06 |
15+ yrs | 23 | 4.35* | 24 | 0.94 | 62 | 2.20* | 159 | 1.21* |
Total | 123 | 2.42* | 191 | 1.23* | 460 | 1.77* | 882 | 1.16* |
Bone sarcoma | Soft tissue sarcoma | |||||||
---|---|---|---|---|---|---|---|---|
Age at 1st | Radiotherapy | No radiotherapy | Radiotherapy | No radiotherapy | ||||
Cancer diagnosis | Obs | SIR | Obs | SIR | Obs | SIR | Obs | SIR |
20-39 yrs | 13 | 4.40* | 10 | 1.31 | 52 | 5.32* | 58 | 2.25* |
40-59 yrs | 42 | 3.71* | 40 | 1.23 | 129 | 2.41* | 219 | 1.37* |
60-79 yrs | 40 | 2.60* | 57 | 1.31 | 177 | 1.83* | 302 | 1.15* |
Bone sarcoma | Soft tissue sarcoma | |||||||
---|---|---|---|---|---|---|---|---|
Radiotherapy | No radiotherapy | Radiotherapy | No radiotherapy | |||||
1st cancer type | Obs | SIR | Obs | SIR | Obs | SIR | Obs | SIR |
Oral Cavity and Pharynx | 9 | 7.61* | 1 | 0.49 | 12 | 1.95* | 8 | 0.75 |
Rectum and Anus | 6 | 5.15* | 6 | 1.77 | 12 | 1.82 | 18 | 0.96 |
Larynx | 2 | 1.62 | 2 | 3.80 | 6 | 0.87 | 3 | 1.06 |
Lung and Bronchus | 0 | 0.00 | 4 | 1.48 | 12 | 3.44* | 19 | 1.30 |
Female Breast | 21 | 2.59* | 21 | 1.28 | 104 | 2.67* | 101 | 1.29* |
Cervix Uteri | 6 | 6.62* | 1 | 0.71 | 10 | 2.38* | 6 | 1.04 |
Corpus Uteri | 12 | 3.96* | 3 | 0.62 | 27 | 1.89* | 29 | 1.25 |
Ovary | 3 | 13.99* | 2 | 1.45 | 6 | 6.25* | 9 | 1.44 |
Prostate | 8 | 1.09 | 19 | 1.38 | 89 | 1.69* | 97 | 1.05 |
Testis | 0 | 0.00 | 0 | 0.00 | 9 | 2.60* | 8 | 2.78* |
Brain and CNS | 3 | 10.47* | 0 | 0.00 | 4 | 3.66* | 3 | 3.44 |
Thyroid | 4 | 4.12* | 2 | 0.91 | 11 | 2.63* | 10 | 1.04 |
Hodgkin Lymphoma | 3 | 4.28 | 3 | 6.37* | 22 | 8.71* | 7 | 3.72* |
Non-Hodgkin Lymphoma | 10 | 9.00 | 7 | 2.92* | 11 | 1.96 | 17 | 1.36 |
Leukemia | 1 | 17.60 | 5 | 3.09* | 1 | 4.17 | 10 | 1.16 |