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Arthritis Research & Therapy

Erschienen in:

01.08.2000 | Review

Cell-cell interactions in synovitis Interactions between T lymphocytes and synovial cells

verfasst von: Iain B McInnes, Bernard P Leung, Foo Y Liew

Erschienen in: Arthritis Research & Therapy | Ausgabe 5/2000

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Abstract

Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between synovial T cells, adjacent macrophages and fibroblast-like synoviocytes (FLS). Thus, T cells activated by cytokines, endothelial transmigration, extracellular matrix or by auto-antigens can promote cytokine, particularly TNFα, metalloproteinase production by macrophages and FLS through cell-membrane interactions, mediated at least through β-integrins and membrane cytokines. Since soluble factors thus induced may in turn contribute directly to T cell activation, positive feedback loops are likely to be created. These novel pathways represent exciting potential therapeutic targets.

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Titel: Cell-cell interactions in synovitis Interactions between T lymphocytes and synovial cells
verfasst von: Iain B McInnes
Bernard P Leung
Foo Y Liew
Publikationsdatum: 01.08.2000
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 5/2000
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar115

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