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Arthritis Research & Therapy

Erschienen in:

01.10.2008 | Review

Immune regulation of bone loss by Th17 cells

verfasst von: Iannis E Adamopoulos, Edward P Bowman

Erschienen in: Arthritis Research & Therapy | Ausgabe 5/2008

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Abstract

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

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Titel: Immune regulation of bone loss by Th17 cells
verfasst von: Iannis E Adamopoulos
Edward P Bowman
Publikationsdatum: 01.10.2008
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 5/2008
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2502

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