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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 5/2009

01.10.2009 | Review

Toll-like receptors and NOD-like receptors in rheumatic diseases

verfasst von: William J McCormack, Andrew E Parker, Luke A O'Neill

Erschienen in: Arthritis Research & Therapy | Ausgabe 5/2009

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Abstract

The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease - the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology of rheumatoid arthritis, ankylosing spondylitis, lyme arthritis and osteoarthritis. Nalp3 has been identified as a key NLR for IL-1β production and has been shown to have a particular role in gout. These findings present new therapeutic opportunities, possibly allowing for the replacement of biologics with small molecule inhibitors.
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Metadaten
Titel
Toll-like receptors and NOD-like receptors in rheumatic diseases
verfasst von
William J McCormack
Andrew E Parker
Luke A O'Neill
Publikationsdatum
01.10.2009
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 5/2009
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2729

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Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

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