Introduction
Rheumatoid arthritis (RA) is a common severe inflammatory disorder characterized by progressive joint damage and functional impairments [
1]. It has been widely reported that the daily-life burdens associated with RA, including functional impairment, chronic and debilitating pain, inability to participate in desired family, social and leisure activities and reduced productivity at work and within the home, have a profound impact on an individual's health-related quality of life (HRQoL) [
2‐
5]. As such, HRQoL is now considered to be an essential outcome measure in many clinical studies [
6] and the American College of Rheumatology (ACR), the European League Against Rheumatism (EULAR) and the Outcomes Measures in Rheumatology (OMERACT) have recognized the importance of measuring functioning and well-being from the patient's perspective in clinical trials [
7].
Another multidimensional burden experienced by almost all RA patients is fatigue. RA-related fatigue has been reported to be more extreme than normal tiredness, to restrict patients' abilities to fulfill their normal family roles and to take a severe emotional toll on patients [
8]. Furthermore, an examination of both the physical and mental components of fatigue revealed that high levels of mental fatigue coincide with elevated levels of bodily pain and physical limitations in patients with RA [
9].
Assessing patient's burden is an important component in monitoring both the progression of disease and the effectiveness of RA therapies. Physician-reported measures offer the physician's assessment of patient's health, while patient-reported assessments of both the physical (fatigue and pain) and mental burden of RA reflect the impact of disease on everyday life. Moreover, some of these symptoms (especially those that are mental/emotional in nature) are known only to, and can thus only be reported by, patients. An analysis of randomized controlled trials has shown that patient-reported outcomes demonstrate better discrimination of the treatment effect than more traditional physician-reported outcomes [
10,
11], and are, therefore, the most sensitive tools for assessing the impact of therapy on RA symptoms [
12]. Taken together, the patient and physician-reported assessments are complementary and provide a holistic picture of a patient's disease state or well-being.
The efficacy and safety of certolizumab pegol (CZP), the only PEGylated anti-TNF for the treatment of RA, has been established in several phase III clinical trials [
13‐
15]. Previously-reported clinical results from the RA PreventIon of Structural Damage 1 (RAPID 1) clinical trial have demonstrated that CZP, dosed at 200 mg or 400 mg every other week plus methotrexate (MTX), provides rapid reductions in the signs and symptoms of active RA (as assessed by ACR responder rates) and improvements in disease activity (as assessed by disease activity scores [DAS28]) in MTX inadequate responders [
15]. In this paper, we present the patient-reported outcome (PRO) results from the RAPID 1 trial, including HRQoL, fatigue, physical function, pain and patient's global assessment of disease activity. To further explore the relation between the patient-reported and clinical (physician-reported) assessments, we also examined the correlations between the PROs and the ACR20 and DAS responses.
Materials and methods
Patients
Full details regarding patient inclusion and exclusion criteria and randomization for RAPID 1 were previously published [
15]. In brief, patients were aged 18 years or older with active RA (according to the 1987 ACR RA classification criteria [
16]) with an inadequate response to MTX therapy (≥ 10 mg weekly for ≥ 6 months with stable doses for ≥ 2 months prior to baseline). Patients were ineligible if they had previously failed to respond to treatment with a TNF inhibitor. All patients provided written informed consent.
Study design
RAPID 1 was a phase III, double-blind, randomized, placebo (PBO)-controlled, multicenter trial in which patients with active RA were randomized 2:2:1 to receive subcutaneous CZP (400 mg weeks 0, 2 and 4 followed by CZP 200 mg or 400 mg) plus MTX every other week, or PBO plus MTX. Patients not achieving ACR20 responses at weeks 12 and 14 were to be withdrawn from treatment per protocol at week 16. These patients, and those who completed RAPID 1, were eligible to enter an ongoing open-label extension study of CZP 400 mg plus MTX every other week. The study (NCT00152386) was conducted in accordance with the International Conference on Harmonisation E6 Note for Guidance on Good Clinical Practice (CPMP/ICH/135/95) and Declaration of Helsinki. All elements of the CONSORT checklist for reporting randomized clinical trials have been previously published in the primary RAPID 1 publication [
15]. Institutional review boards or ethics committees approved the protocol at each center, and all patients provided written consent.
Patient-reported outcomes
All patient-reported outcomes assessed in the RAPID 1 trial were secondary endpoints. These PROs included evaluations of concepts such as HRQoL, fatigue and the patient-reported components of the ACR core set criteria (physical function, arthritis pain and patient's global assessment of disease activity). The PRO instruments assessed in RAPID 1 have been shown to provide valid and reliable data in prior RA research. They were properly implemented in the CZP trials in terms of patient and investigator training, timing of assessments, linguistic validations, and pre-specification of analysis in the statistical analysis plan. Psychometric properties of the data based on the endpoints of the patient-reported outcomes are consistent with prior evidence of the measurement properties for each instrument.
HRQoL was assessed using the Short-Form 36-Items (SF-36) health survey (Version 1.0 standard recall), which is a widely used generic HRQoL instrument with numerous studies documenting its validity and reliability as an accurate measure of generic health concepts in RA [
4,
10,
17‐
21]. SF-36 assesses eight domains: Physical Functioning, Role Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role Emotional and Mental Health, scored from 0 to 100, with higher scores indicating better HRQoL [
22]. The Physical Component Summary (PCS) and the Mental Component Summary (MCS) scores were obtained from normalized and z-transformed domain scores, with normative values of 50 and standard deviations of 10. Minimum clinically important differences (MCIDs) for the SF-36 domains are defined as a 5.0 or more point increase from baseline and a 2.5 or more point increase from baseline for PCS and MCS scores [
23]. Baseline SF-36 domain scores were compared with US population norms adjusted for the age and gender distribution of the trial population.
Fatigue (weariness, tiredness) over the past week was evaluated using the Fatigue Assessment Scale (FAS), a numeric rating scale (NRS) from 0 to 10 with higher scores indicating greater fatigue [
24]. The MCID for the FAS is 10% of the scale range, corresponding to a one-point change [
25]. Physical function was assessed by the Health Assessment Questionnaire-Disability Index (HAQ-DI), evaluating eight activities of daily living [
26,
27]. HAQ-DI scores range from 0 to 3, with higher scores indicating lower levels of physical functioning. Improvements of 0.22 or more points from baseline represent the HAQ-DI MCID [
28]. Patient's arthritis pain and patient's global assessment of disease activity (PtGA) were evaluated using 0 to 100 mm visual analog scales (VAS), where higher scores indicate greater pain and disease activity. MCIDs for both pain VAS and PtGA are defined as 10 mm improvements from baseline [
25,
28‐
30].
The SF-36 was completed at baseline, week 12 and every 12 weeks thereafter until week 52 or withdrawal. All other patient-reported outcomes were assessed at baseline, weeks 1 and 2 and every 2 weeks until week 20, followed by every 4 weeks until week 52 or early withdrawal. Fatigue (FAS) was additionally assessed at weeks 5 and 9.
Statistical analyses
Analyses were conducted on the intent-to-treat (ITT) population, which included all randomized patients receiving at least 1 dose of study treatment. Changes from baseline in PRO scores were analyzed using Analysis of Covariance (ANCOVA) with region and treatment as factors, and baseline score as covariate (using last observation carried forward (LOCF) imputation of missing data). Sensitivity analyses were performed using the repeated measures direct likelihood method. The proportions of patients reporting improvements equal to or greater than the determined MCID for each PRO (post hoc analyses) were compared using repeated-measures logistic regression with region, treatment, time and treatment by time interaction as factors and baseline score as covariate. Response rates (i.e., proportions of patients with clinically meaningful improvements) in pain VAS, HAQ-DI, fatigue NRS, and SF-36 PCS and MCS were compared at week 52 to clinical response rates, defined as a decrease from baseline in DAS28 of 1.2 units or an ACR20 response, by cross tabulation. For analysis of response rates, patients with missing data after rescue medication intake or withdrawal were imputed with a conservative approach of non-responders.
Discussion
Over the past decade, the management of RA has changed dramatically as a result of the development of the TNF inhibitors, which have resulted in improved long-term outcomes. Initially, improved clinical responses achieved by the use of TNF inhibitors were the primary focus of clinicians. Now the RA burden as reported by patients has come to be recognized as a significant and treatable component of the disease. Utilized together, clinical and patient-reported outcomes reflect the spectrum of patients' disease and best reflect the overall effectiveness of TNF inhibitor therapy in RA.
Concepts that have traditionally been shown to be among the most important to RA patients are physical function, pain, and tiredness (fatigue). However, it is now well-documented that mental health disturbance is an important consequence of RA and a central component of the assessment of HRQoL. Therefore in RAPID 1, the concepts that were assessed as reported by the patients were HRQoL (including emotional, social and physical components), fatigue, physical function, arthritis pain, and global assessment of disease activity.
Patients in this trial (RAPID 1) had substantially diminished HRQoL at baseline compared with age- and gender-matched US population norms (particularly in Vitality, Role Emotional, Physical Function, Role Physical and Bodily Pain), as illustrated by the spydergram of SF-36 scores at baseline (Figure
2). The US population norms were used only as a benchmark to allow comparisons between RA patients with available general population data. Following treatment with either dose of CZP plus MTX, patients reported improvements in HRQoL, or 'multidimensional function', at first assessment (week 12), with large improvements in both the physical and mental domains of HRQoL that exceeded MCID. In particular, energy (Vitality) and emotional state (mental health) domain scores approached normative values of the general population in the US, and the significant improvement in SF-36 MCS scores observed with CZP plus MTX treatment in this trial, which approached levels of improvement in PCS scores, is novel among studies of TNF inhibitors in RA [
31‐
35]. The negative psychological effects of RA are well documented; many patients with RA have mood and anxiety disorders [
36], and it has been reported that 21% to 39% of patients with RA experience significant depressive symptoms [
37,
38], although treatment of these aspects of the disease is often suboptimal. The improvements in SF-36 MCS and mental health scores following CZP treatment are thus particularly relevant for patients because they may help them return to normal levels of emotional functioning.
Patients treated with CZP plus MTX also reported significant improvements in global assessment of disease activity and physical function, as well as relief of pain and fatigue, as early as week 1 of treatment. Although there was a small decrease in the percentage of patients reporting clinically meaningful reductions in fatigue from week 4 to week 52, this is likely because of protocol-mandated withdrawal at week 16 for failure to achieve ACR20 responses at weeks 12 and/or 14, as well as imputation of withdrawn subjects with the conservative approach of non-responders after week 16. Reductions in fatigue and all other PROs with CZP plus MTX remained highly significant throughout the trial, with approximately 50% of patients reporting clinically meaningful reductions by week 52. In general, the effect of CZP on the patient-reported outcomes described herein are comparable with those reported with other TNF inhibitors in clinical studies [
31,
32,
33,
34,
35,
39] as well as in studies in clinical practice [
19,
32,
34,
40‐
43]. However, the rapid improvements in patient-reported outcomes in CZP-treated patients, particularly those reflecting improved mental health, which have not previously been observed, are a particularly interesting characteristic of this new anti-TNF.
Patient's daily burden of disease and their poor HRQoL directly limit their everyday activities as well as productivity at work and within the home with negative consequences for society. Results from the RAPID 1 trial have demonstrated that CZP treatment improves productivity at work and at home, including fewer number of days lost engaging in family, social and leisure activities [
44]. Furthermore, a
post hoc analysis demonstrated that these improvements in productivity were closely reflected by similar changes in pain, physical function and fatigue (unpublished observations).
The data presented in this paper demonstrate that the CZP-treated patients experience early improvements in all patient-reported outcomes over PBO. In addition, there have been data suggesting that rapid improvements in disease activity are associated with better long-term outcomes [
45]. Patients have a greater chance of avoiding long-term disability, allowing them to regain their normal levels of physical, emotional and social participation and greatly improving overall HRQoL.
Previously reported results from the RAPID 1 trial have demonstrated that treatment with CZP plus MTX rapidly and significantly reduces disease activity (as assessed by DAS28 scores) and improves the clinical signs and symptoms of RA (as assessed by ACR20 response rates) [
15]. The improvements in patient-reported outcomes following CZP treatment reported herein thus support and complement these previously reported clinical improvements. In addition, the analyses correlating responses as assessed by improvements in PROs with clinical (ACR and DAS) responses demonstrate that patient-reported outcomes correlate well with physician-reported, clinical indices. Not surprisingly, because the HAQ-DI and pain are components of the ACR20 response rate criteria, physical function and pain were highly correlated with ACR20 response rates. In contrast, changes in SF-36 PCS and MCS scores had the lowest correlation with ACR20 and DAS responses. These results illustrated that although clinical measures and PROs are generally well correlated, assessment of only clinical measures does not capture all aspects of RA and its impact on patients' physical and mental health. Assessment of both clinical (physician-reported) and patient-reported outcomes is thus necessary to fully elucidate treatment benefit.
Competing interests
VS has received consulting fees from UCB, Inc. PM, GB, RvV, BC, EK, and AK have received research grants and consulting fees from UCB, Inc. EN is a Life Sciences Business & Decision consultant working as consultant for UCB, Inc. GC is an employee of UCB, Inc.
Authors' contributions
PM, GB, RvV, BC, EK and AK made substantial contributions to the data acquisition, analysis, and interpretation and reviewed and revised the article content. VS, GC and EN participated in the analysis and interpretation of the data, and VS and EN drafted the manuscript. All authors read and approved the final manuscript.