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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 3/2002

01.05.2002 | Review

Matrix metalloproteinases in arthritic disease

verfasst von: Gillian Murphy, Vera Knäuper, Susan Atkinson, George Butler, William English, Mike Hutton, Jan Stracke, Ian Clark

Erschienen in: Arthritis Research & Therapy | Sonderheft 3/2002

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Chapter summary

The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential therapeutic agents have been made. However, the spectrum of these enzymes orchestrating connective tissue turnover and general biology is much larger than anticipated. Biochemical studies of the individual members of the matrix metalloproteinase family are now underway, ultimately leading to a more detailed understanding of the function of their domain structures and to defining their specific role in cellular systems and the way that they are regulated. Coupled with a more comprehensive and detailed study of proteinase expression in different cells of joint tissues during the progress of arthritic diseases, it will be possible for the future development and application of highly specific proteinase inhibitors to be directed at specific key cellular events.
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Metadaten
Titel
Matrix metalloproteinases in arthritic disease
verfasst von
Gillian Murphy
Vera Knäuper
Susan Atkinson
George Butler
William English
Mike Hutton
Jan Stracke
Ian Clark
Publikationsdatum
01.05.2002
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe Sonderheft 3/2002
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar572

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