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Breast Cancer Research
Erschienen in: Breast Cancer Research 3/2002

01.06.2002 | Review

CCAAT/enhancer binding proteins in normal mammary development and breast cancer

verfasst von: Cynthia A Zahnow

Erschienen in: Breast Cancer Research | Ausgabe 3/2002

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Abstract

CCAAT/enhancer binding proteins (C/EBPs) are a family of leucine zipper, transcription factors that bind to DNA as homodimers and heterodimers. They regulate cellular proliferation, differentiation and apoptosis in the mammary gland. Multiple protein isoforms, including truncated, dominant negatives, are generated by translation of the C/EBPβ transcript or via proteolytic cleavage of the full-length C/EBPβ protein. Gene deletion of individual C/EBP family members has demonstrated an essential role for C/EBPβ in normal mammary development, while transgenic and overexpression studies provide evidence that the dominant-negative C/EBPβ-liver-enriched inhibitory protein isoform induces proliferation in mammary epithelial cells. Mounting evidence suggests that alterations in the ratio of the C/EBPβ-liver-enriched inhibitory protein isoform and the C/EBPβ-liver-enriched activating protein isoform may play a role in the development of breast cancer. This review will consequently focus on C/EBP actions in normal mammary development and on the emerging data that supports a role in breast cancer.
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Metadaten
Titel
CCAAT/enhancer binding proteins in normal mammary development and breast cancer
verfasst von
Cynthia A Zahnow
Publikationsdatum
01.06.2002
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 3/2002
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr428

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