Background
Methods
Study design and participants
Measurements
Characteristics
Outcome measures
Statistical analysis
Results
Deprescribing for polypharmacy | P-valuea | ||
---|---|---|---|
Acceptance | Refusal | ||
N = 82 | N = 54 | ||
Age, mean ± SD | 80.3 ± 7.5 | 82.3 ± 7.4 | 0.14 |
Men, n (%) | 22 (26.8) | 12 (22.2) | 0.69 |
Institutional resident, n (%) | 10 (12.2) | 7 (13.0) | 1.00 |
CCI, mean ± SD | 1.9 ± 1.5 | 1.7 ± 1.7 | 0.50 |
Current smoker, n (%) | 3 (3.7) | 7 (13.0) | 0.05 |
Regular drinker, n (%) | 7 (8.5) | 8 (14.8) | 0.28 |
Number of medications at admission, mean ± SD | 9.6 ± 3.2 | 9.0 ± 2.3 | 0.22 |
Primary reason for admission, n (%) | |||
Fracture | 56 (68.3) | 41 (75.9) | 0.44 |
Osteoarthritis | 6 (7.3) | 7 (13.1) | 0.37 |
Spinal stenosis | 9 (11.0) | 3 (5.6) | 0.36 |
Other | 11 (13.4) | 3 (5.6) | 0.16 |
Past medical history, n (%) | |||
Depression | 6 (7.3) | 8 (14.8) | 0.25 |
Insomnia | 28 (34.1) | 21 (38.9) | 0.59 |
Dementia | 15 (18.3) | 11 (20.4) | 0.83 |
Stroke | 23 (28.0) | 10 (18.5) | 0.23 |
Myocardial infarction | 8 (9.8) | 6 (11.1) | 0.78 |
Heart failure | 8 (9.8) | 3 (5.6) | 0.53 |
Diabetes mellitus | 19 (23.2) | 11 (20.4) | 0.83 |
Asthma or COPD | 10 (12.2) | 4 (7.4) | 0.57 |
Rheumatological disease | 10 (12.2) | 6 (11.1) | 1.00 |
Active cancer | 7 (8.5) | 2 (3.7) | 0.20 |
Deprescribing for polypharmacy | P-valueb | ||
---|---|---|---|
Acceptance | Refusal | ||
N = 82 | N = 54 | ||
Number of PIMs, mean ± SD | 1.5 ± 1.2 | 1.6 ± 1.3 | 0.52 |
Any PIMs, n (%) | 64 (78.0) | 41 (75.9) | 0.84 |
Category of PIMs, n (%) | |||
Benzodiazepines | 30 (36.6) | 18 (33.3) | 0.72 |
Proton pump inhibitors | 26 (31.7) | 19 (35.2) | 0.71 |
NSAIDs | 7 (8.5) | 7 (13.0) | 0.41 |
Hypnotics | 8 (9.8) | 5 (9.3) | 1.00 |
Anticholinergics | 3 (3.7) | 6 (11.1) | 0.16 |
Anticonvulsive drugs | 4 (4.9) | 5 (9.3) | 0.48 |
Antipsychotics | 7 (8.5) | 1 (1.9) | 0.15 |
Opioids | 2 (2.4) | 5 (9.3) | 0.11 |
Antidepressants | 3 (3.7) | 4 (7.4) | 0.43 |
Ticlopidine or dipyridamole | 5 (6.1) | 1 (1.9) | 0.40 |
Peripheral alpha-1 blocker | 2 (2.4) | 4 (7.4) | 0.22 |
Odds ratio (95% confidence interval) | ||
---|---|---|
Univariable | Multivariablea | |
Increasing ageb | 1.04 (0.99-1.09) | 1.05 (0.99-1.10) |
Male gender | 0.78 (0.35-1.75) | 0.78 (0.32-1.89) |
Institutional resident | 1.07 (0.38-3.01) | 0.58 (0.16-2.12) |
Increasing CCIb | 0.93 (0.74-1.16) | 1.00 (0.77-1.31) |
Dementia | 1.14 (0.48-2.72) | 0.91 (0.29-2.85) |
Depression | 2.20 (0.72-6.75) | 2.05 (0.58-7.23) |
Insomnia | 1.23 (0.60-2.50) | 1.01 (0.42-2.48) |
Regular drinker | 1.86 (0.63-5.48) | 1.80 (0.55-5.89) |
Current smoker | 3.92 (0.97-15.91) | 3.76 (0.86-16.45) |
Increasing number of medications at admissionb | 0.92 (0.81-1.05) | 0.90 (0.78-1.05) |
Increasing number of PIMsc at admissionb | 1.09 (0.83-1.44) | 1.13 (0.75-1.71) |