Background
Methods
Patients and methods
Treatment
Laboratory measurements
Follow-up
Statistical analysis
Results
Patient characteristics
Variable | All | Absent leucopenia | Mild leucopenia | Severe leucopenia | P value |
---|---|---|---|---|---|
Total | 3826 | 508(13.3) | 2511(65.6) | 807(21.1) | |
Gender | <0.001 | ||||
male | 2873(75.1) | 421(82.9) | 1936(77.1) | 516(63.9) | |
female | 953(24.9) | 87(17.1) | 575(22.9) | 291(36.1) | |
Age(years) | 0.105 | ||||
<45 | 1982(51.8) | 242(47.6) | 1325(52.8) | 415(51.4) | |
> = 45 | 1844(48.2) | 266(52.4) | 1186(47.2) | 392(48.6) | |
Leukocyte count | <0.001 | ||||
= < 10 × 10^9/L | 3448(90.1) | 424(83.5) | 2278(90.7) | 746(92.4) | |
>10 × 10^9/L | 378(9.9) | 84(16.5) | 233(9.3) | 61(7.6) | |
Pathological type(WHO) | 0.692 | ||||
I | 83(2.2) | 11(2.2) | 55(2.2) | 17(2.1) | |
II | 203(5.3) | 23(4.5) | 143(5.7) | 37(4.6) | |
III | 3540(92.5) | 474(93.3) | 2313(92.1) | 753(93.3) | |
T-classification | 0.720 | ||||
T1 | 172(4.5) | 22(4.3) | 109(4.3) | 41(5.1) | |
T2 | 272(7.1) | 29(5.7) | 185(7.4) | 58(7.2) | |
T3 | 1871(48.9) | 271(53.3) | 1221(48.6) | 379(47.0) | |
T4 | 1511(39.5) | 186(36.6) | 996(39.7) | 329(40.8) | |
N-classification | 0.09 | ||||
N0 | 517(13.5) | 86(16.9) | 335(13.3) | 96(11.9) | |
N1 | 1978(51.7) | 252(49.6) | 1313(52.3) | 413(51.2) | |
N2 | 1043(27.3) | 133(26.2) | 680(27.1) | 230(28.5) | |
N3 | 288(7.5) | 37(7.3) | 183(7.3) | 68(8.4) | |
Clinical stage | 0.222 | ||||
III | 2094(54.7) | 295(58.1) | 1369(54.5) | 430(53.3) | |
IV | 1732(45.3) | 213(41.9) | 1142(45.5) | 377(46.7) | |
Radiotherapy | 0.004 | ||||
CRT | 2583(67.5) | 329(64.8) | 1741(69.3) | 513(63.6) | |
IMRT | 1243(32.5) | 179(35.2) | 770(30.7) | 294(36.4) | |
Chemotherapy | <0.001 | ||||
IC | 1073(28.0) | 198(39.0) | 697(27.8) | 178(22.1) | |
CC | 1291(33.7) | 202(39.8) | 878(35.0) | 211(26.1) | |
IC + CC | 1255(32.8) | 98(19.3) | 804(32.0) | 353(43.7) | |
CC + AC | 207(5.4) | 10(2.0) | 132(5.3) | 65(8.1) | |
Paclitaxel | <0.001 | ||||
NO | 3029(79.2) | 403(79.3) | 2069(82.4) | 557(69.0) | |
YES | 797(20.8) | 105(20.7) | 442(17.6) | 250(31.0) | |
Chemotherapy cycles | <0.001 | ||||
<4 | 2364(61.8) | 400(78.7) | 1575(62.7) | 389(48.2) | |
> = 4 | 1462(38.2) | 108(21.3) | 936(37.3) | 418(51.8) |
Survival analyses including leucopenia
All population | Cycles <4 population | Cycles > =4 population | ||||
---|---|---|---|---|---|---|
Variable | OS | DMFS | OS | DMFS | OS | DMFS |
Leucopenia | ||||||
Mild VS Absent | ||||||
HR(95 %CI) | 0.70(0.57-0.86) | 0.79(0.63-0.98) | 0.73(0.57-0.92) | 0.87(0.66-1.14) | 0.56(0.38-0.86) | 0.56(0.37-0.86) |
p
| 0.001 | 0.038 | 0.009 | 0.309 | 0.007 | 0.008 |
Severe VS Absent | ||||||
HR(95 %CI) | 0.77(0.60-0.97) | 1.01(0.78-1.31) | 0.86(0.63-1.16) | 1.10(0.79-1.54) | 0.59(0.38-0.90) | 0.73(0.46-1.14) |
P
| 0.030 | 0.927 | 0.320 | 0.554 | 0.016 | 0.166 |
Mild VS Severe | ||||||
HR(95%CI) | 0.91(0.76-1.09) | 0.77(0.64-0.93) | 0.85(0.66-1.08) | 0.78(0.61-1.02) | 0.98(0.75-1.28) | 0.77(0.58-1.09) |
p
| 0.314 | 0.007 | 0.191 | 0.069 | 0.887 | 0.058 |
Gender | ||||||
HR(95 %CI) | 0.62(0.51-0.75) | 0.69(0.57-0.84) | 0.63(0.50-0.79) | 0.71(0.55-0.91) | 0.61(0.45-0.84) | 0.67(0.49-0.2) |
P
| <0.001 | <0.001 | <0.001 | 0.007 | 0.002 | 0.015 |
Age | ||||||
HR(95 %CI) | 1.84(1.59-2.14) | 1.09(0.93-1.27) | 1.93(1.59-2.34) | 1.14(0.94-1.39) | 1.73(1.36-2.19) | 1.01(0.77-1.30) |
P
| <0.001 | 0.304 | <0.001 | 0.191 | <0.001 | 0.941 |
T-classification | ||||||
HR(95 %CI) | 1.27(1.14-1.40) | 1.09(0.99-1.22) | 1.27(1.11-1.45) | 1.11(0.96-1.27) | 1.26(1.07-1.49) | 1.08(0.91-1.27) |
P
| <0.001 | 0.092 | 0.001 | 0.157 | 0.007 | 0.375 |
N-classification | ||||||
HR(95CI) | 1.56(1.43-1.70) | 1.65(1.50-1.81) | 1.70(1.51-1.90) | 1.75(1.54-1.97) | 1.39(1.21-1.60) | 1.52(1.32-1.76) |
P
| <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
Radiotherapy | ||||||
HR(95 %CI) | 0.80(0.68-0.94) | 0.91(0.76-1.08) | 0.88(0.70-1.10) | 1.03(0.82-1.30) | 0.69(0.54-0.89) | 0.75(0.58-0.97) |
P
| 0.008 | 0.273 | 0.264 | 0.764 | 0.005 | 0.030 |
All population | Cycles <4 population | Cycles > =4 population | ||||
---|---|---|---|---|---|---|
Variable | OS | DMFS | OS | DMFS | OS | DMFS |
Leucopenia | ||||||
Mild VS Absent | ||||||
HR(95 %CI)a | 0.69(0.56-0.85) | 0.77(0.61-0.96) | 0.70(0.55-0.89) | 0.88(0.63-1.23) | 0.73(0.46-1.15) | 0.61(0.40-0.94) |
P
| <0.001 | 0.023 | 0.003 | 0.452 | 0.174 | 0.025 |
Severe VS Absent | ||||||
HR(95 %CI)a | 0.75(0.59-0.95) | 0.99(0.77-1.29) | 0.82(0.60-1.11) | 0.79(0.61-1.03) | 0.97(0.74-1.27) | 0.84(0.53-1.32) |
P
| 0.019 | 0.995 | 0.204 | 0.083 | 0.828 | 0.446 |
Mild VS Severe | ||||||
HR(95 %CI)a | 0.93(0.77-1.11) | 0.77(0.64-0.93) | 0.85(0.66-1.09) | 0.90(0.68-1.19 | 0.71(0.46-1.07 | 0.73(0.56-0.96) |
P
| 0.416 | 0.006 | 0.204 | 0.469 | 0.108 | 0.026 |
Gender | ||||||
HR(95 %CI) | 0.67(0.55-0.81) | 0.70(0.58-0.86) | 0.66(0.52-0.84) | 0.73(0.57-0.93) | 0.66(0.48-0.91) | 0.68(0.49-0.94) |
P
| <0.001 | <0.001 | 0.001 | 0.013 | 0.010 | 0.019 |
Age | ||||||
HR(95 %CI) | 1.82(1.57-2.12) | 1.05(0.89-1.23) | 1.88(1.55-2.28) | 1.09(0.89-1.34 | 1.71(1.34-2.17) | 1.03(0.81-1.33) |
P
| <0.001 | 0.532 | <0.001 | 0.367 | <0.001 | 0.783 |
T-classification | ||||||
HR(95 %CI) | 1.49(1.35-1.66) | 1.33(1.19-1.47) | 1.51(1.33-1.72) | 1.36(1.19-1.56) | 1.49(1.26-1.76) | 1.27(1.08-1.51) |
P
| <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.005 |
N-classification | ||||||
HR(95CI) | 1.77(1.62-1.93) | 1.78(1.62-1.97) | 1.92(1.71-2.16) | 1.92(1.68-2.18) | 1.56(1.35-1.80) | 1.63(1.40-1.90) |
P
| <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |