Background
Methods
Publication search
Inclusion and exclusion criteria
Data extraction and qualitative assessment
Statistical analysis
Results
Literature searching results and baseline characteristics of included studies
First author | Year | Country | Ethnicity | Language | Disease | Method | Case Number | Sample source | Gender (M/F) | Age (years) |
---|---|---|---|---|---|---|---|---|---|---|
Hirano H | 2015 | Japan | Asians | English | NSCLC | IHC | 157 | tissue | 115/42 | 66.7(47–82) |
Hu S | 2013 | China | Asians | English | NSCLC | IHC | 256 | tissue | 176/80 | 57.7 |
Sun PL | 2013 | Korea | Asians | English | NSCLC | IHC | 373 | tissue | 258/115 | 65.0(21–84) |
Zhang XY | 2012 | China | Asians | Chinese | NSCLC | IHC(SP) | 60 | tissue | 35/25 | 54.0(30–78) |
Peng X | 2012 | China | Asians | English | NSCLC | IHC | 97 | tissue | 75/22 | 58.3(28–75) |
Wang M | 2012 | China | Asians | English | NSCLC | IHC | 210 | tissue | 130/80 | 59.8(35–76) |
Gao Q | 2012 | China | Asians | English | NSCLC | IHC | 62 | tissue | 44/18 | 57.8(35–78) |
Hu FQ | 2011 | China | Asians | Chinese | NSCLC | IHC(Envision) | 116 | tissue | 78/38 | 65.8(35–84) |
Guosheng L | 2011 | China | Asians | English | NSCLC | IHC(SP) | 100 | tissue | 69/31 | 55.6(37–76) |
Fan CF | 2011 | China | Asians | English | NSCLC | IHC | 76 | tissue | 46/30 | 57.1(26–78) |
Zhu CZ | 2010 | China | Asians | Chinese | NSCLC | IHC(SP) | 60 | tissue | 39/21 | 62.1(33–78) |
Yang DX | 2010 | China | Asians | Chinese | NSCLC | IHC(PowerVision) | 60 | tissue | 40/20 | 53.5(37–71) |
Zeng ZH | 2010 | China | Asians | Chinese | NSCLC | IHC | 60 | tissue | 38/22 | 65.7(40–78) |
Porebska I | 2010 | Poland | Caucasians | English | NSCLC | IHC | 74 | tissue | 49/25 | 60.5(43–77) |
Chen YQ | 2009 | China | Asians | English | NSCLC | IHC(SP) | 120 | tissue | 94/26 | 61.0(42–76) |
Li CH | 2008 | China | Asians | Chinese | NSCLC | IHC(PV) | 91 | tissue | 77/14 | 62.0(39–78) |
Shi M | 2007 | China | Asians | Chinese | NSCLC | IHC | 80 | tissue | 55/25 | 56.2(33–79) |
Miao LJ | 2007 | China | Asians | Chinese | NSCLC | IHC(SP) | 80 | tissue | 53/27 | 58.8(18–78) |
Xue ZX | 2006 | China | Asians | Chinese | NSCLC | IHC(SP) | 84 | tissue | 51/33 | 53.2(22–75) |
Wang M | 2006 | China | Asians | Chinese | NSCLC | IHC | 72 | tissue | 45/27 | 58.5(38–74) |
Li XC | 2006 | China | Asians | Chinese | NSCLC | IHC(SABC) | 64 | tissue | 41/23 | 55.6(35–78) |
Yoo J | 2006 | Korea | Asians | English | NSCLC | IHC | 219 | tissue | 168/51 | 65.8 ± 9.9 |
Huo XD | 2006 | China | Asians | Chinese | NSCLC | IHC(Envision) | 117 | tissue | 85/32 | 57.5(29–71) |
Vischioni B | 2006 | Netherlands | Caucasians | English | NSCLC | IHC | 160 | tissue | 129/31 | 64.0(40–86) |
Akyurek N | 2006 | Turkey | Caucasians | English | NSCLC | IHC | 78 | tissue | 72/6 | 60.8(39–78) |
Ren YJ | 2006 | China | Asians | Chinese | NSCLC | IHC(Envision) | 61 | tissue | 45/16 | 62.0(40–75) |
Qiu HL | 2005 | China | Asians | Chinese | NSCLC | IHC(SP) | 75 | tissue | 51/24 | 57.1 ± 10.6 |
Shinohara ET | 2005 | America | Caucasians | English | NSCLC | IHC | 144 | tissue | 94/50 | 65.4 ± 11.04 |
The comparison between NSCLC patients and normal controls on survivin protein expression
The analysis of survivin expression and clinicopathologic characteristics of NSCLC
Studies | Ethnicity (n) | Studies (n) | Combined RR (95 % CI) | P(Z) | I2 | P(Q) |
---|---|---|---|---|---|---|
NSCLC vs. Control | All | 19 | 7.16(4.63-11.07) | <0.001 | 58.1 % | 0.001 |
Asians | 18 | 6.60(4.33-10.05) | <0.001 | 55..4 % | 0.002 | |
Caucasians | 1 | 101(6.34-1608) | 0.001 | / | / | |
Squamous cell carcinoma vs. Adenocarcinoma | All | 22 | 1.00(0.93, 1.07) | 0.983 | 7.0 % | 0.367 |
Asians | 19 | 0.97(0.90-1.05) | 0.44 | 0 % | 0.189 | |
Caucasians | 3 | 1.01(0.78-1.30) | 0.959 | 40.0 % | 0.515 | |
Well/Moderately differentiated vs. Poor differentiated | All | 21 | 0.80(0.73-0.87) | <0.001 | 45.4 % | 0.013 |
Asians | 20 | 0.78(0.72-0.86) | <0.001 | 33 % | 0.077 | |
Caucasians | 1 | 0.96(0.86-1.08) | 0.487 | / | / | |
TNMI/II stage vs. TNM III/IVstage | All | 26 | 0.75(0.67-0.84) | <0.001 | 72.7 % | <0.001 |
Asians | 22 | 0.74(0.65-0.84) | <0.001 | 71.4 % | <0.001 | |
Caucasians | 4 | 0.89(0.75-1.07) | 0.222 | 39 % | 0.178 | |
Lymph node metastasis vs. Non lymph node metastasis | All | 25 | 1.14(1.01-1.29) | 0.035 | 71.5 % | <0.001 |
Asians | 22 | 1.16(1.01-1.34) | 0.037 | 72.7 % | <0.001 | |
Caucasians | 3 | 1.03(0.80-1.32) | 0.839 | 64.2 % | 0.061 | |
Small Tumor vs. Big Tumor | All | 11 | 0.95(0.86-1.05) | 0.336 | 18.1 % | 0.272 |
Asians | 9 | 0.98(0.85-1.13) | 0.796 | 31 % | 0.171 | |
Caucasians | 2 | 0.90(0.78-1.04) | 0.161 | 0 % | 0.729 |
Contrasts | Subcellular locolization | Study (n) | Combined RR (95 % CI) | P(Z) | I2 | P(Q) |
---|---|---|---|---|---|---|
NSCLC vs. Control | All | 19 | 7.16(4.63-11.07) | <0.001 | 58.1 % | 0.001 |
Cytoplasma | 9 | 7.14(4.19-12.16) | <0.001 | 43.8 % | 0.076 | |
Cytoplasma or nuclearus | 5 | 3.96(1.93-8.14) | <0.001 | 46.1 % | 0.115 | |
Cytoplasma and nuclearus | 2 | 17.41(1.2-252.4) | 0.036 | 70.5 % | 0.065 | |
Squamous cell carcinoma vs. Adenocarcinoma | All | 22 | 0.99(0.92, 1.07) | 0.866 | 7.0 % | 0.367 |
Cytoplasma | 11 | 0.98(0.88-1.08) | 0.641 | 0 % | 0.767 | |
Cytoplasma or nuclearus | 6 | 0.98(0.83-1.15) | 0.771 | 30.8 % | 0.204 | |
Cytoplasma and nuclearus | 2 | 1.74(1.12-2.71) | 0.013 | 0 % | 0.324 | |
Well/Moderately differentiated vs. Poor differentiated | All | 21 | 0.80(0.73-0.87) | <0.001 | 45.4 % | 0.013 |
Cytoplasma | 8 | 0.84(0.75-0.93) | 0.001 | 19.6 % | 0.274 | |
Cytoplasma or nuclearus | 7 | 0.68(0.52-0.88) | 0.003 | 68.9 % | 0.004 | |
Cytoplasma and nuclearus | 2 | 0.73(0.46-1.16) | 0.179 | 42.7 % | 0.186 | |
TNMI/II stage vs. TNM III/IVstage | All | 26 | 0.75(0.67-0.84) | <0.001 | 72.7 % | <0.001 |
Cytoplasma | 12 | 0.83(0.69-1.01) | 0.059 | 74.1 % | <0.001 | |
Cytoplasma or nuclearus | 8 | 0.73(0.61-0.88) | 0.001 | 74.5 % | <0.001 | |
Cytoplasma and nuclearus | 2 | 0.73(0.41-1.29) | 0.278 | 59.7 % | 0.115 | |
Lymph node metastasis vs. Non lymph node metastasis | All | 25 | 1.14(1.01-1.29) | 0.035 | 71.5 % | <0.001 |
Cytoplasma | 10 | 1.24(1.07-1.44) | 0.005 | 53.1 % | 0.024 | |
Cytoplasma or nuclearus | 9 | 1.12(0.89-1.41) | 0.352 | 76.6 % | <0.001 | |
Cytoplasma and nuclearus | 2 | 0.96(0.32-2.91) | 0.949 | 83.1 % | 0.015 | |
Small Tumor vs. Big Tumor | All | 11 | 0.95(0.86-1.05) | 0.336 | 18.1 % | 0.272 |
Cytoplasma | 6 | 0.97(0.79-1.19) | 0.738 | 48.3 % | 0.085 | |
Cytoplasma or nuclearus | 4 | 0.92(0.83-1.04) | 0.226 | 0 % | 0.565 | |
Cytoplasma and nuclearus | 1 | 1.09(0.71-1.67) | 0.691 | / | / |
Sensitivity analysis and publication bias
Meta-regression analysis
Heterogeneity factors | Coefficient | SE | t |
P
| 95 % CI | |
---|---|---|---|---|---|---|
LL | UL | |||||
Country | 82.25 | 25.89 | 3.18 | 0.037 | 27.37 | 137.13 |
Ethnicity | 78.35 | 27.13 | 3.08 | 0.025 | 26.15 | 120.65 |
Language | 8.82 | 18.07 | 0.49 | 0.598 | −29.49 | 47.12 |
Sample Size | −0.18 | 0.37 | −0.49 | 0.234 | −26.96 | 102.39 |