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Erschienen in: BMC Pulmonary Medicine 1/2016

Open Access 01.12.2016 | Research article

Mean pulmonary arterial pressure as a prognostic indicator in connective tissue disease associated with interstitial lung disease: a retrospective cohort study

verfasst von: Kota Takahashi, Hiroyuki Taniguchi, Masahiko Ando, Koji Sakamoto, Yasuhiro Kondoh, Naohiro Watanabe, Tomoki Kimura, Kensuke Kataoka, Atsushi Suzuki, Satoru Ito, Yoshinori Hasegawa

Erschienen in: BMC Pulmonary Medicine | Ausgabe 1/2016

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Abstract

Background

Pulmonary hypertension (PH) can develop in connective tissue disease associated interstitial lung disease (CTD-ILD), and contributes to increased morbidity and mortality. However, except for systemic sclerosis and mixed connective tissue disease, the impact of mean pulmonary arterial pressure (MPAP) on survival in CTD-ILD has not been sufficiently elucidated. We hypothesized that pulmonary arterial pressure may be a prognostic factor in CTD-ILDs regardless of the kind of CTD.

Methods

We evaluated the survival impact of MPAP, which is measured using right heart catheterization, on survival of patients with CTD-ILD with various CTD backgrounds. We retrospectively analyzed data of consecutive CTD-ILD patients undergoing a pulmonary function test and right-heart-catheterization at the initial evaluation.

Results

We studied 74 patients (33 men and 41 women, mean age 62.8 ± 9.6, 24 with rheumatoid arthritis, 14 with systemic sclerosis, 14 with polymyositis/dermatomyositis, 11 with primary Sjögren’s syndrome, and 11 with other diagnoses). Six patients exhibited pulmonary hypertension (MPAP ≥ 25 mmHg), and 16 (21.6 %) had mild elevation of MPAP (≥20 mmHg). The mean MPAP was 17.2 ± 5.5 mmHg. We did not observe a significant difference in MPAP among various CTDs. A univariate Cox proportional hazard model showed that MPAP has a significant impact on survival, while the type of CTD did not contribute to survival in our cohort. A multivariate Cox proportional hazard model showed MPAP (HR = 1.087; 95 % CI 1.008–1.172; p = 0.030) to be the sole independent determinant of survival.

Conclusions

Mild elevation of MPAP is relatively common in CTD-ILD patients with various CTD backgrounds. A higher MPAP at the initial evaluation was a significant independent predictor of survival in CTD-ILD. MPAP evaluation provides additional information on disease status and will help physicians predict mortality in CTD-ILD.
Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

KT: had access to and took responsibility for the integrity of the data and the accuracy of the data analysis. HT: contributed to the data conception and design; data analysis and interpretation; and final approval of the manuscript. MA: contributed to preparation, data analysis, review, writing and submission of this manuscript. KS: contributed to preparation, review, writing and submission of this manuscript. YK: contributed to design of this project, data analysis, review, writing and submission of this manuscript. NW: contributed to data collection, preparation, review, writing and submission of this manuscript. TK: contributed to data collection, organization, preparation, review, and submission of this manuscript. KK: contributed to data collection, organization, analysis, preparation, review, and submission of this manuscript. AS: contributed to data collection, preparation, review, and submission of this manuscript. SI: contributed to data collection, preparation, review, writing and submission of this manuscript. YH: contributed to envisioning the initial concept and design of this project, and submission of this manuscript. All authors have read and approved the final version of the manuscript.
Abkürzungen
A-a gradient
alveolar-arterial O2 tension gradient
CTD
connective tissue disease
CTD-ILD
connective tissue disease associated interstitial lung disease
DLco
diffusing lung capacity of carbon monoxide
FVC
forced vital capacity
ILD
interstitial lung disease
IPF
idiopathic pulmonary fibrosis
LTOT
long-term oxygen therapy
MCTD
mixed connective tissue disease
MPAP
mean pulmonary arterial pressure
PAH
pulmonary arterial hypertension
PaO2
arterial oxygen tension
PCWP
pulmonary capillary wedge pressure
PH
Pulmonary hypertension
PM/DM
polymyositis/dermatomyositis
PVR
pulmonary vascular resistance
PVRI
pulmonary vascular resistance index
RA
rheumatoid arthritis
RHC
right heart catheterization
RV
residual volume
SjS
Sjögren’s syndrome
SLE
systemic lupus erythematosus
SSc
systemic sclerosis
TLC
total lung capacity

Background

Patients with pulmonary hypertension (PH) in association with underlying interstitial lung disease (ILD) have worse survival rates than those with ILD alone [13]. PH in patients with systemic sclerosis (SSc) and ILD (SSc-ILD) further worsens survival, but there are few data regarding outcomes in SSc-ILD patients with PH compared with those with the other connective tissue disease (CTD) associated ILD [4, 5].
Recently, the importance of mild elevation in pulmonary arterial pressure has been recognized in patients with several ILDs. It has been demonstrated that a mean pulmonary arterial pressure (MPAP) between 21 and 24 mmHg is clinically relevant and affects patient outcome in idiopathic pulmonary fibrosis (IPF) [3, 6]. Furthermore, mild elevation of MPAP is also implicated in SSc patients [7]. Fischer et al. proposed “lung-dominant CTD” (LD-CTD) as a concept for classifying the subset of patients with ILD who have clinical features suggesting an associated CTD, but whose features fall short of a clear diagnosis of CTD under the current rheumatologic classification systems [8]. More recently, we elucidated that MPAP ≥ 20 mmHg affects patient outcome in LD-CTD [9].
To date, little information is available regarding prognostic factors in ILDs with various CTD backgrounds. We hypothesized that pulmonary arterial pressure may be a prognostic factor in CTD-ILDs in spite of the kind of CTD. The aim of this study was to determine whether MPAP predicts survival in CTD-ILD patients whose disease background, pulmonary function test, and right heart catheterization (RHC) data are available. The significance of mild MPAP elevation (≥20 mmHg) was also explored [9].

Methods

Subjects

In this study, we retrospectively analyzed our ILD patient database, which registers the results of systematic evaluations undergone at the time of their initial consultation with our department at Tosei General Hospital (Aichi, Japan). Of 619 records of patients with ILD examined between July 2007 and June 2012, 102 were diagnosed with CTD-ILD. Twenty-eight patients were excluded from the study for the following reasons: (1) they had been treated with PH targeted therapy, (2) evaluation was done using supplemental oxygen, (3) they were suffering from an unstable disease, such as acute exacerbation, infection, or heart failure, or (4) RHC was not performed within 3 months of initial evaluation or RHC data was missing. Finally, we reviewed the charts of 74 stable CTD-ILD patients who underwent RHC for evaluation during this period (Fig. 1).
PH was assessed by RHC and defined as a pulmonary arterial pressure ≥ 25 mmHg. In this study, we also adopted MPAP ≥ 20 mmHg as a cut-off for predicting the prognosis based on our previous study of lung-dominant CTD patients [9].
This study was approved by the Tosei General Hospital Institutional Review Board (IRB No. 483). Patient records and information were anonymized and de-identified prior to analysis. The diagnosis of ILD was made clinically by high-resolution CT (HRCT) [10]. Pathological diagnoses of 33 patients were confirmed by surgical lung biopsy but did not meet the criteria for the clinical diagnosis of IPF [11] or other definite ILDs. The clinical diagnosis of CTD for each subject, which was made according to established criteria, was also classified and recorded as : SSc, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis/dermatomyositis (PM/DM), mixed connective tissue disease (MCTD), or Sjögren’s syndrome (SjS) (all according to established criteria) [1218].

Measurements

We recorded patients’ demographic characteristics, results of pulmonary function tests (PFTs), PaO2 assessed by arterial blood gas analysis, diagnosis of CTD, medication record, and hemodynamics measured by RHC, retrospectively. All patients underwent spirometry (CHESTAC-55 V; Chest, Tokyo, Japan), according to the method described in the ATS 1994 update [19]. Single-breath diffusing lung capacity of carbon monoxide (DLCO) was also measured (CHESTAC-55 V). The values for forced vital capacity (FVC) and DLCO were related to % predicted values [20]. RHC was performed using a Swan-Ganz catheter percutaneously inserted into either a cubital vein or femoral vein under normal conditions as the patient breathed room air. We did not perform a vasoreactivity test. MPAP was measured with the catheter tip placed within the right main trunk of the pulmonary artery. Cardiac output was measured by a thermodilution method.

Statistical analysis

Survival status was ascertained in September 2014. Among 74 eligible patients, 15 deaths were observed. This study had at least 70 % statistical power to detect a difference of 40 % in 5-year survival rates (80 % vs 40 %) between patients with MPAP < 20 mmHg and those with MPAP ≥ 20 mmHg at the 5 % significance level. Continuous variables were summarized as the mean ± SD or the median and range and compared using Student’s t-test or Wilcoxon’s rank sum test where appropriate. Categorical variables were compared using the chi-square statistic. Pearson’s correlation coefficient was used to evaluate the correlations between MPAP and clinical values. If either variable had a non-normal distribution, correlations were calculated using Spearman’s correlation test. Univariate Cox’s proportional hazard models were used to examine the association of selected variables with survival. A multivariate analysis was used to elucidate independent prognostic factors. Variables with p < 0.15 were used for entry into the model. To avoid multicolinearity, only one of the highly correlated variables (coefficient of correlation ≥ 0.9) was used in the multivariate model, if more than one was present. Using the methods of Kaplan-Meier and the log-rank test, we studied the impact of variables on survival. P values less than 0.05 were considered significant. All analyses were performed using a statistical software package (SPSS, version 19.0; SPSS, Inc., Chicago, IL).

Results

The baseline demographic and clinical characteristics of the 74 patients are summarized in Table 1. The numbers of patients with RA, SSc, PM/DM, SjS, MCTD, SLE, and overlap syndrome were 24 (32.4 %), 14 (18.9 %), 14 (18.9 %), 11 (14.9 %), 5 (6.8 %), 1 (1.4 %), and 5 (6.8 %), respectively. Thirty three patients (44.6 %) underwent surgical lung biopsy. Forty-seven patients (65.2 %) had decreases in diffusing capacity. Six patients (8.1 %) had PH (MPAP ≥ 25 mmHg): three with PM/DM and one each with RA and MCTD, respectively. Sixteen patients (21.6 %) had MPAP ≥ 20 mmHg: 7 with RA, 4 with PM/DM, two each with SSc and MCTD, and one with overlap syndrome, respectively. The patients with RA, SSc, PM/DM, SjS, MCTD, SLE, and overlap syndrome had a mean ± SD MPAP of 17.0 ± 5.0 mmHg, 16.3 ± 4.1 mmHg, 17.6 ± 6.0 mmHg, 16.1 ± 5.7 mmHg, and 23.5 ± 8.7 mmHg, 19.0 mmHg, and 16.3 ± 3.7 mmHg, respectively. Twenty seven patients (36.5 %) received pharmacological treatment for CTD or ILD at the RHC evaluation. Twenty three patients (31.1 %) were treated with oral corticosteroids. Ten patients (13.5 %) were treated with an immunosuppressive agent (cyclosporin:tacrolimus:cyclophosphamide:methotrexate 6:2:1:1). Four patients (5.4 %) were treated with beraprost sodium orally for Raynaud’s phenomenon. No patient was treated with PH targeted therapy and antithrombotic agents for PH. No patient had received long-term oxygen therapy (LTOT) at the time of RHC evaluation.
Table 1
Baseline characteristics of all patients with CTD-ILD
Variable
 
Range
Sex, M/F
33/41
Age, years
63.5 ± 1.1
38–78
BMI, kg/m2
23.0 ± 4.0
13.7–35.3
Smoking status, ever/never
31/43
CTD
 
RA/SSc/PMDM/SjS/MCTD/
24/14/14/11/5
SLE/overlap syndrome
1/5
Surgical lung biopsy, yes/no
33/41
Corticosteroids/immunosuppressant
23/10
FVC, % predicted
81.0 ± 19.1
38.3–127.0
DLco, % predicted
57.1 ± 19.2
22.6–113.6
RV, % predicted
81.2 ± 31.5
17.9–181.9
TLC, % predicted
80.3 ± 18.3
47.9–138.6
PaO2, mmHg
80.8 ± 9.9
60.2–103.2
A-a gradient, mmHg
20.2 ± 11.5
−3.8–38.1
MPAP, mmHg
17.2 ± 5.5
8–36
CI, l/min/m2
3.59 ± 0.77
1.89–5.18
PVR, Wood units
127.3 ± 59.9
34.0–406.0
PVRI, Wood units/m2
223.5 ± 102.1
52.0–606.0
Age is presented as median ± SE. Data are presented as mean ± SD unless otherwise noted. BMI: body mass index; RA: rheumatoid arthritis; SSc: systemic sclerosis; PM/DM: polymyositis/dermatomyositis; SjS: Sjögren’s syndrome; MCTD: mixed connective tissue disease; SLE: systemic lupus erythematosus; FVC: forced vital capacity; DLco: diffusing capacity of the lung for carbon monoxide; RV: residual volume, TLC: total lung capacity, PaO2: arterial oxygen tension; A-a gradient: alveolar-arterial O2 tension gradient, MPAP: mean pulmonary arterial pressure; CI: cardiac index; PVR: pulmonary vascular resistance; PVRI: pulmonary vascular resistance index. N = 74 except for DLco (n = 72)
In terms of survival analysis, fifteen patients (20.3 %) died during the mean observation period of 44.4 ± 2.2 months: six deaths were due to advanced respiratory failure, four due to acute exacerbation, three due to malignant disease, one due to multiple organ failure, and one due to neuromuscular disease. The univariate Cox regression model (Table 2) demonstrated that MPAP (p = 0.014) had a statistically significant impact on survival. Sex (p = 0.106), smoking status (p = 0.102), and RV, % predicted (p = 0.102) did not reach statistical significance. The multivariate analysis including all relevant variables with p values < 0.15 in univariate analysis showed that only MPAP (HR = 1.087; 95 % CI1.008–1.172, p = 0.030) was significantly correlated with survival (Table 3). Patients with PH (MPAP ≥ 25 mmHg) had a significantly worse prognosis than those without PH (HR = 3.995; 95 % CI 1.267–12.60, p = 0.018). When we conducted further analysis of survival time to respiratory specific death (including only deaths due to respiratory failure), MPAP still significantly correlated with survival (HR = 1.154; 95 % CI1.033–1.289, p = 0.011). In addition, there was no association between any CTD background and survival (SSc and MCTD vs. the others: HR = 1.186; 95 % CI0.333–4.223, p = 0.792, RA vs. the others: HR = 0.530; 95 % CI0.192–1.465, p = 0.221, and PM/DM vs. the others: HR = 1.739; 95 % CI0.392–7.714, p = 0.467).
Table 2
Results of univariate Cox proportional hazard model for mortality
Variable
HR
95 % CI
P value
Age, years
1.018
0.958–1.082
0.570
Sex, M/F
2.366
0.833–6.721
0.106
BMI, kg/m2
0.956
0.841–1.087
0.493
Smoking status, ever/never
2.377
0.842–6.706
0.102
SSc + MCTD diagnosis vs. others
1.186
0.333–4.223
0.792
RA diagnosis vs. others
0.530
0.192–1.465
0.221
PM/DM diagnosis vs. others
1.739
0.392–7.714
0.467
Corticosteroids and/or
immunosuppressant use, yes/no
0.666
0.236–1.885
0.444
FVC, % predicted
0.998
0.972–1.025
0.889
DLCO, % predicted
0.982
0.951–1.013
0.252
RV, % predicted
1.010
0.998–1.023
0.102
TLC, % predicted
1.005
0.979–1.033
0.699
PaO2, mmHg
0.978
0.928–1.032
0.420
A-a gradient, mmHg
1.025
0.982–1.071
0.259
MPAP, mmHg
1.093
1.018–1.175
0.014
CI, l/min/m2
0.651
0.304–1.392
0.268
PVR, Wood units
1.005
0.998–1.011
0.189
PARI, Wood units/m2
1.003
0.999–1.008
0.156
HR: hazard ratio; CI: confidence interval (see Table 1 for other definitions)
Table 3
Results of multivariate Cox proportional hazard model for mortality
Variable
HR
95 % CI
P value
Sex, M/F
1.747
0.465–6.563
0.409
Smoking, ever/never
1.740
0.467–6.482
0.409
RV, % predicted
1.007
0.993–1.021
0.322
MPAP, mmHg
1.087
1.008–1.172
0.030
Variables used were P value < 0.15 in univariate analysis (Table 2)
To evaluate the significance of mild elevation of MPAP with a cutoff point of 20 mmHg for survival, the following analysis was performed. As shown in Table 4, patients were stratified according to MPAP with the cutoff point of 20 mmHg, and their baseline characteristics and physiology were compared. Male sex and a history of smoking were more frequent in patients with MPAP ≥ 20 mmHg. Figure 2 shows a Kaplan-Meier curve that reveals significantly worse survival among patients whose MPAP was ≥ 20 mmHg than among those whose MPAP was < 20 mmHg (log-rank test p = 0.023).
Table 4
Baseline characteristics and physiology of patients with and without MPAP ≥ 20 mmHg
Variable
MPAP < 20 mmHg
MPAP ≥ 20 mmHg
P value
(N = 58)
(N = 16)
Sex, M/F
24/34
9/7
<0.001
Age, years
62.9 ± 9.0
61.9 ± 11.4
0.777
BMI
22.7 ± 3.9
23.8 ± 4.3
0.270
Smoking, ever/never
22/36
9/7
<0.001
FVC, % predicted
82.5 ± 19.3
76.0 ± 17.4
0.318
DLCO, % predicted
58.8 ± 17.9
51.2 ± 23.0
0.092
RV, % predicted
82.6 ± 30.9
76.3 ± 34.2
0.867
TLC, % predicted
82.6 ± 18.9
72.5 ± 13.8
0.343
PaO2, mmHg
81.3 ± 10.2
78.6 ± 8.9
0.627
A-a gradient, mmHg
18.7 ± 11.6
25.1 ± 10.0
0.182
MPAP, mmHg
14.9 ± 2.8
24.9 ± 4.3
<0.001
Cardiac index, l/min/m2
3.36 ± 0.69
3.49 ± 0.79
0.458
PVRI, Wood units/m2
188.6 ± 73.9
258.2 ± 115.6
<0.001
Data are presented as means ± SD or numbers
N = 74 except for DLCO (N = 72)

Discussion

This is the first study, to our knowledge, to report the impact of MPAP on survival in patients of ILD with various backgrounds of CTD. We also elucidated the frequency of mild elevation of pulmonary artery pressure in this population. This study included patients with milder pulmonary function impairment (mean FVC 81.0 %, mean DLco 57.1 %) and lower MPAP (mean MPAP 17.2 mmHg) than the subjects of previous studies of IPF and SSc [7, 8]. However, a higher MPAP was shown to be an independent prognostic predictor in this population. This result suggests the importance of evaluating MPAP at an early stage in patients with CTD-ILD, and not limiting it to patients with advanced disease. Furthermore, it was shown that CTD-ILD patients with MPAP ≥ 20 mmHg had a significantly lower survival rate than those with MPAP < 20 mmHg by a log-rank test. Suzuki et al. [9] reported similar results on survival for lung-dominant CTD using the same cutoff level. Our study also demonstrated that MPAP ≥ 20 mmHg was closely associated with prognosis in CTD-ILD, which is consistent with the result in lung-dominant -CTD.
The pathogenesis of PH is likely to be complex and driven by multiple mechanisms [21]. As shown in Table 4, patients with MPAP ≥ 20 mmHg were more frequently found to have a smoking history, although we did not find a significant relationship between smoking and survival (p = 0.102). Notably, PH had a higher prevalence in cases of combined pulmonary fibrosis and emphysema (CPFE). These patients had clinical fibrosis associated with emphysema and smoking status [22]. Recent work has suggested that cigarette smoking plays a role in PH through inducing oxidative stress in human and animal models [23]. In addition, we have described the relationship between smoking and mild elevation of MPAP in mild IPF [6]. Our results indicate that smoking may play a role in the development of PH in CTD-ILD. Further investigation will be required to determine whether this is the case.
SSc generally represents the main CTD associated with PH. Additionally, PH occurs in 19–53 % of patients with MCTD [24, 25]. In our study, PH and MPAP ≥ 20 mmHg were frequently observed in ILD associated other types of CTD, such as RA (7 of 24, 29.2 %) and PM/DM (4 of 14, 28.6 %) in spite of excluding patients with hypoxemia. Interestingly, the prognosis of ILD patients with SSc or MCTD is not worse than those with the other CTDs. Additionally, in the case with MPAP ≥ 25 mmHg and ≥ 20 mmHg, similar results were confirmed. Launay et al. [26] reported that PH-complicated SSc was frequently detected in patients both with and without ILD. However, little is known about the prevalence and prognosis in ILD associated PH with the other CTD backgrounds. We speculate that the prevalence of PH may have clinical importance also in other CTD-ILDs such as ILD with RA and PM/DM. Therefore, it is recommended that physicians who diagnose ILD with various CTD backgrounds be careful about the elevation of pulmonary arterial pressure at the initial evaluation.
In this study, twenty three patients (31.1 %) were treated with oral corticosteroids. Ten patients (13.5 %) were treated with immunosuppressive agents. CTD-ILD patients tend to be treated with immunosuppressive therapies, although there have been few systematic and prospective studies [27, 28]. A previous study suggested that some CTD-PH patients could also benefit from immunosuppressive therapies [29]. However, in our study the therapy was not significantly associated with survival in CTD-ILD (p = 0.444).
Our study has several limitations. First, it is a small retrospective review at a single center, which included only patients without severe hypoxemia. Therefore, it is difficult to generalize from the result to the composition of CTD-ILD patients with severe disease status. Further large studies are needed to confirm our results. Second, we did not evaluate two clinical variables that can be confounding factors: vasoreactivity and nocturnal hypoxemia. When several statistical variables are addressed in such a small study, one wonders whether several statistical variables are truly significant or just a result of multiple comparisons. A vasoreactivity test is recommended for PAH to confirm the efficacy of calcium channel blockers. However, it is not recommended for other PH groups [3]. Therefore, further studies are needed to evaluate the significance of the vasoreactivity test for CTD-ILD. Additionally, we did not evaluate nocturnal hypoxemia. Minai et al. reported that nocturnal hypoxia is common in PAH and a risk factor for advanced pulmonary hypertension [30]. Therefore, nocturnal hypoxemia might be a prognostic factor in CTD-ILD. Additional studies to elucidate the impact of nocturnal desaturation on CTD-ILD are needed. Third, our results may be subject to treatment bias. Four patients were treated with beraprost for Raynaud’s phenomenon (not for PH), which may affect MPAP. In addition, systemic steroids and immunosuppressants affect vascular remodeling and inflammatory/autoimmune pathogenesis. It has not been elucidated whether systemic steroids and immunosuppressants affect the prognosis and pulmonary arterial pressure of patients with CTD-ILD [5]. Because additional analysis eliminating these cases did not alter any conclusion of the current study, we believe this bias did not skew our results seriously. Admittedly, further study is needed to identify whether the therapy affects MPAP and survival. Third, in some cases, the causes of death were not directly related to the patients’ CTD or ILD. However, a similar result was observed in the analysis excluding the cases that were related to non-pulmonary death. To recognize the effect of mild MPAP elevation on survival rates, further clinical studies need to be conducted with a larger population and over a longer observation period.

Conclusions

We demonstrated that MPAP has a statistically significant impact on survival and that mild elevation of MPAP is relatively common in CTD-ILD patients with various CTD backgrounds. MPAP evaluation provides additional information on disease status and will help physicians to predict mortality in CTD-ILD.

Acknowledgments

This work was supported in part by a grant-in-aid for the Diffuse Lung Disease Research Group from the Japanese Ministry of Health, Labor and Welfare and the NPO Respiratory Disease Conference.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

KT: had access to and took responsibility for the integrity of the data and the accuracy of the data analysis. HT: contributed to the data conception and design; data analysis and interpretation; and final approval of the manuscript. MA: contributed to preparation, data analysis, review, writing and submission of this manuscript. KS: contributed to preparation, review, writing and submission of this manuscript. YK: contributed to design of this project, data analysis, review, writing and submission of this manuscript. NW: contributed to data collection, preparation, review, writing and submission of this manuscript. TK: contributed to data collection, organization, preparation, review, and submission of this manuscript. KK: contributed to data collection, organization, analysis, preparation, review, and submission of this manuscript. AS: contributed to data collection, preparation, review, and submission of this manuscript. SI: contributed to data collection, preparation, review, writing and submission of this manuscript. YH: contributed to envisioning the initial concept and design of this project, and submission of this manuscript. All authors have read and approved the final version of the manuscript.
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Metadaten
Titel
Mean pulmonary arterial pressure as a prognostic indicator in connective tissue disease associated with interstitial lung disease: a retrospective cohort study
verfasst von
Kota Takahashi
Hiroyuki Taniguchi
Masahiko Ando
Koji Sakamoto
Yasuhiro Kondoh
Naohiro Watanabe
Tomoki Kimura
Kensuke Kataoka
Atsushi Suzuki
Satoru Ito
Yoshinori Hasegawa
Publikationsdatum
01.12.2016
Verlag
BioMed Central
Erschienen in
BMC Pulmonary Medicine / Ausgabe 1/2016
Elektronische ISSN: 1471-2466
DOI
https://doi.org/10.1186/s12890-016-0207-3

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