Background
Subjects and methods
Subjects
Anthropometric parameters
Laboratory examination
Ultrasound Examination
Definition of variables
Statistical Analysis
Results
Baseline Features of General Population
Total | TNs | without TNs | χ2/w/t | P value | |
---|---|---|---|---|---|
Total(%) | 121,702 | 41,547(34.1) | 80,155(65.9) | ||
Female | 48,563 | 19,734(40.6) | 28,829(59.4) | 1517.33 | < 0.001 |
Male | 73,139 | 21,813(29.8) | 51,326(70.2) | ||
Age (years) | 42.44 ± 13.24 | 47.89 ± 13.97 | 39.62 ± 11.90 | -102.924 | < 0.001 |
Age(years,%) | |||||
≤ 30 | 25,455 | 4912(19.3) | 20,543(80.7) | 1.10 × 109 | < 0.001 |
31–40 | 35,672 | 8527(23.9) | 27,145(76.1) | ||
41–50 | 27,063 | 10,080(37.2) | 16,983(62.8) | ||
51–60 | 20,062 | 9845(49.1) | 10,217(50.9) | ||
≥ 61 | 13,450 | 8183(60.8) | 5267(39.2) | ||
BMI(Kg/m2) | 23.51 ± 4.06 | 23.72 ± 3.89 | 23.40 ± 4.15 | -12.477 | < 0.001 |
WC(cm) | 81.37 ± 9.95 | 81.87 ± 9.83 | 81.10 ± 10.00 | -12.234 | < 0.001 |
SBP (mmHg) | 123.61 ± 17.30 | 126.36 ± 18.58 | 122.20 ± 16.42 | -36.724 | < 0.001 |
DBP(mmHg) | 75.07 ± 11.54 | 76.26 ± 11.84 | 74.45 ± 11.33 | -24.5 | < 0.001 |
FBG(mmol/L) | 5.43 ± 1.19 | 5.57 ± 1.35 | 5.36 ± 1.10 | -26.95 | < 0.001 |
TC(mmol/L) | 4.91 ± 0.94 | 4.99 ± 0.95 | 4.87 ± 0.93 | -20.69 | < 0.001 |
TG(mmol/L) | 1.64 ± 1.49 | 1.66 ± 1.48 | 1.63 ± 1.49 | -2.71 | < 0.001 |
HDL-C(mmol/L) | 1.40 ± 0.34 | 1.42 ± 0.35 | 1.39 ± 0.34 | -12.8 | < 0.001 |
LDL-C(mmol/L) | 2.96 ± 0.81 | 3.01 ± 0.82 | 2.93 ± 0.81 | -15.18 | < 0.001 |
UA(µmol/L) | 350.32 ± 95.51 | 340.72 ± 93.52 | 355.26 ± 96.15 | 25.21 | < 0.001 |
Female | 279.92 ± 62.28 | 283.38 ± 64.73 | 277.57 ± 60.45 | -9.827 | < 0.001 |
Male | 396.3 ± 84.83 | 391.6 ± 85.34 | 398.29 ± 84.53 | 9.71 | < 0.001 |
Fatty Liver | |||||
No | 84,098 | 27,696(32.9) | 56,402(67.1) | 146.61 | < 0.001 |
Yes | 33,976 | 12,442(36.7) | 21,534(63.3) |
Association Between Metabolic Factors and TNs risk
Total | Male | Female | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
TNs(N,%) | Normal(N,%) | OR(95% CI) | Pvalue | TNs(N,%) | Normal(N,%) | OR(95% CI) | P value | TNs(N,%) | Normal(N,%) | OR(95% CI) | P value | |
BMI(Kg/m2) | ||||||||||||
≤ 18.4 | 1321(26.0) | 3751(74.0) | 0.71(0.67–0.76) | < 0.01 | 319(21.7) | 1152(78.3) | 0.73(0.64–0.83) | < 0.01 | 1002(28.1) | 2599(71.9) | 0.60(0.56–0.65) | < 0.01 |
18.5–23.9 | 19,603(33.1) | 39,659(66.9) | 1.0(ref) | 1.00 | 8333(27.5) | 22,009(72.5) | 1.0(ref) | 1.00 | 11,270(39.0) | 17,659(61.0) | 1.0(ref) | 1.00 |
24.0-27.9 | 13,418(36.5) | 23,390(63.5) | 1.16(1.13–1.19) | < 0.01 | 9270(32.2) | 19,509(67.8) | 1.25(1.21–1.30) | < 0.01 | 4148(51.7) | 3881(48.3) | 1.67(1.59–1.76) | < 0.01 |
≥ 28.0 | 3313(35.7) | 5976(64.3) | 1.12(1.07–1.17) | < 0.01 | 2418(31.7) | 5207(68.3) | 1.23(1.16–1.30) | < 0.01 | 895(53.8) | 769(46.2) | 1.82(1.65–2.01) | < 0.01 |
Central obesity | ||||||||||||
No | 19,166(31.4) | 41,810(68.6) | 1.0(ref) | 1.00 | 7670(25.8) | 22,104(74.2) | 1.0(ref) | 1.00 | 11,496(36.8) | 19,706(63.2) | 1.0(ref) | 1.00 |
Yes | 18,455(37.4) | 30,890(62.6) | 1.30(1.27–1.34) | < 0.01 | 12,661(33.0) | 25,727(67.0) | 1.42(1.37–1.47) | < 0.01 | 5794(52.9) | 5163(47.1) | 1.92(1.84–2.01) | < 0.01 |
Hypertension | ||||||||||||
No | 26,954(31.0) | 60,094(69.0) | 1.0(ref) | 1.00 | 13,406(26.3) | 37,593(73.7) | 1.0(ref) | 1.00 | 13,548(37.6) | 22,501(62.4) | 1.0(ref) | 1.00 |
Yes | 10,829(45.6) | 12,933(54.4) | 1.87(1.81–1.92) | < 0.01 | 6985(40.2) | 10,392(59.8) | 1.88(1.82–1.95) | < 0.01 | 3844(60.2) | 2541(39.8) | 2.51(2.38–2.65) | < 0.01 |
Glucose status | ||||||||||||
Normal | 34,700(32.5) | 71,915 | 1.0(ref) | 1.00 | 17,328(27.8) | 45,033(72.2) | 1.0(ref) | 1.00 | 17,372(39.3) | 26,882(60.7) | 1.0(ref) | 1.00 |
IFG | 2324(42.9) | 3091(57.1) | 1.56(1.47–1.65) | < 0.01 | 1591(38.5) | 2539(61.5) | 1.63(1.53–1.74) | < 0.01 | 733(57.0) | 552(43.0) | 2.05(1.84–2.30) | < 0.01 |
DM | 3446(50.1) | 3437(49.9) | 2.08(1.98–2.18) | < 0.01 | 2529(46.3) | 2937(53.7) | 2.24(2.12–2.37) | < 0.01 | 917(64.7) | 500(35.3) | 2.84(2.54–3.17) | < 0.01 |
TC(mmol/L) | ||||||||||||
≤ 5.2 | 25,162(32.1) | 53,194(67.9) | 1.0(ref) | 1.00 | 13,284(28.9) | 32,705(71.7) | 1.0(ref) | 1.00 | 20,489(63.3) | 11,878(36.7) | 1.0(ref) | 1.00 |
> 5.2 | 15,464(37.7) | 25,606(62.3) | 1.28(1.25–1.31) | < 0.01 | 8233(31.4) | 18,008(68.6) | 1.13(1.09–1.16) | 0.01 | 7231(48.8) | 7598(51.2) | 1.64(1.58–1.71) | < 0.01 |
TG(mmol/L) | ||||||||||||
≤ 1.7 | 27,586(33.5) | 54,778(66.5) | 1.0(ref) | 1.00 | 12,307(28.9) | 30,276(71.1) | 1.0(ref) | 1.00 | 15,279(38.4) | 24,502(61.6) | 1.0(ref) | 1.00 |
> 1.7 | 13,040(35.2) | 24,022(64.8) | 1.08(1.05–1.11) | < 0.01 | 9210(31.1) | 20,437(68.9) | 1.11(1.07–1.15) | < 0.01 | 3830(51.7) | 3585(48.3) | 1.71(1.63–1.80) | < 0.01 |
HDL-C(mmol/L) | ||||||||||||
≥ 0.9 | 38,754(34.1) | 74,737(65.9) | 1.00 | 20,025(29.7) | 47,374(70.3) | 1.00 | 18,729(40.6) | 27,363(59.4) | 1.00 | |||
< 0.9 | 1664(33.5) | 3309(66.5) | 0.97(0.91–1.03) | 0.32 | 1426(31.9) | 3049(68.1) | 1.11(1.04–1.18) | < 0.01 | 238(47.8) | 260(52.2) | 1.34(1.12–1.60) | < 0.01 |
LDL-C(mmol/L) | ||||||||||||
≤ 3.1 | 23,077(32.6) | 47,762(67.4) | 1.0(ref) | 1.00 | 11,380(29.1) | 27,678(70.9) | 1.0(ref) | 1.00 | 11,697(36.8) | 20,084(63.2) | 1.0(ref) | 1.00 |
> 3.1 | 17,341(36.4) | 30,284(63.6) | 1.19(1.16–1.21) | < 0.01 | 10,071(30.7) | 22,745(69.3) | 1.08(1.04–1.11) | < 0.01 | 7270(49.1) | 7539(50.9) | 1.66(1.59–1.72) | 0.01 |
HUA(µmol/L) | ||||||||||||
No | 31,978(34.9) | 59,717(65.1) | 1.0(ref) | 1.00 | 15,165(30.7) | 34,237(69.3) | 1.0(ref) | 1.00 | 25,480(60.2) | 16,813(39.8) | 1.0(ref) | 1.00 |
Yes | 8632(31.1) | 19,139(68.9) | 0.84(0.82–0.87) | < 0.01 | 6354(27.8) | 16,512(72.2) | 0.87(0.84–0.90) | < 0.01 | 2278(46.4) | 2627(53.6) | 1.31(1.24–1.39) | < 0.01 |
Fatty Liver | ||||||||||||
No | 27,696(32.9) | 56,402(67.1) | 1.0(ref) | 1.00 | 12,533(28.3) | 31,706(71.7) | 1.0(ref) | 1.00 | 15,163(38.0) | 24,696(62.0) | 1.0(ref) | 1.00 |
Yes | 12,442(36.7) | 21,534(63.3) | 1.18(1.15–1.21) | < 0.01 | 8879(32.2) | 18,662(67.8) | 1.20(1.16–1.24) | < 0.01 | 3563(55.4) | 2872(44.6) | 2.02(1.92–2.13) | < 0.01 |
Association Between Metabolic Factors and MTNs compared with STNs
Total | Male | Female | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
STNs(N,%) | MTNs(N,%) | OR(95% CI) | Pvalue | STNs(N,%) | MTNs(N,%) | OR(95% CI) | P value | STNs(N,%) | MTNs(N,%) | OR(95% CI) | P value | |
BMI(Kg/m2) | ||||||||||||
≤ 18.4 | 679(51.4) | 642(48.6) | 0.96(0.86–1.07) | 0.43 | 163(51.1) | 156(48.9) | 1.15(0.92–1.44) | 0.21 | 516(51.5) | 486(48.5) | 0.84(0.73–0.95) | < 0.01 |
18.5–23.9 | 9854(50.3) | 9749(49.7) | 1.0(ref) | 1.00 | 4555(54.7) | 3778(45.3) | 1.0(ref) | 1.00 | 5299(47.0) | 5971(53.0) | 1.0(ref) | 1.00 |
24.0-27.9 | 6497(48.4) | 6921(51.6) | 1.08(1.03–1.13) | < 0.01 | 4873(52.6) | 4397(47.4) | 1.09(1.03–1.15) | < 0.01 | 1624(39.2) | 2524(60.8) | 1.38(1.28–1.48) | < 0.01 |
≥ 28.0 | 1626(49.1) | 1687(50.9) | 1.05(0.97–1.13) | 0.21 | 1311(54.2) | 1107(45.8) | 1.02(0.93–1.12) | 0.70 | 315(35.2) | 580(64.8) | 1.63(1.42–1.88) | < 0.01 |
Central obesity(cm) | ||||||||||||
No | 9826(51.3) | 9340(48.7) | 1.0(ref) | 1.00 | 4278(55.8) | 3392(44.2) | 1.0(ref) | 1.00 | 5548 (48.3) | 5948(51.7) | 1.0(ref) | 1.00 |
Yes | 8813(47.8) | 5390(52.2) | 1.15(1.11–1.20) | < 0.01 | 6622(52.3) | 6039(47.7) | 1.15(1.09–1.22) | < 0.01 | 2191(37.8) | 3603(62.2) | 1.53(1.44–1.64) | < 0.01 |
Hypertension | ||||||||||||
No | 14,096(52.3) | 12,858(47.7) | 1.0(ref) | 1.00 | 7591(56.6) | 5815(43.4) | 1.0(ref) | 1.00 | 6505(48.0) | 7043(52.0) | 1.0(ref) | 1.00 |
Yes | 4626(42.7) | 6203(57.3) | 1.47(1.41–1.54) | < 0.01 | 3339(47.8) | 3646(52.2) | 1.43(1.35–1.51) | < 0.01 | 1287(33.5) | 2557(66.5) | 1.84(1.70–1.98) | < 0.01 |
Glucose status | ||||||||||||
Normal | 17,704(51.0) | 16,996(49.0) | 1.0(ref) | 1.00 | 9614(55.5) | 7714(44.5) | 1.0(ref) | 1.00 | 8090(46.6) | 9289(53.4) | 1.0(ref) | 1.00 |
IFG | 1049(45.1) | 1275(54.9) | 1.27(1.16–1.38) | < 0.01 | 799(50.2) | 792(49.8) | 1.24(1.11–1.37) | < 0.01 | 250(34.1) | 483(65.9) | 1.68(1.44–1.97) | < 0.01 |
DM | 1392(40.4) | 2054(59.6) | 1.54(1.43–1.65) | < 0.01 | 1109(43.9) | 1420(56.1) | 1.60(1.47–1.74) | < 0.01 | 283(30.9) | 634(69.1) | 1.95(1.69–2.25) | < 0.01 |
TC(mmol/L) | ||||||||||||
≤ 5.2 | 12,825(51.0) | 12,337(49.0) | 1.0(ref) | 1.00 | 7099(53.4) | 6185(46.6) | 1.0(ref) | 1.00 | 5726(48.2) | 6152(51.8) | 1.0(ref) | 1.00 |
> 5.2 | 7385(47.8) | 8079(52.2) | 1.14(1.09–1.18) | < 0.01 | 4452(54.1) | 3781(45.9) | 0.97(0.92–1.03) | 0.36 | 2933(40.6) | 4298(59.4) | 1.36(1.29–1.45) | < 0.01 |
TG(mmol/L) | ||||||||||||
≤ 1.7 | 13,697(49.7) | 13,889(50.3) | 1.0(ref) | 1.00 | 6488(52.7) | 5819(47.3) | 1.0(ref) | 1.00 | 7209(47.2) | 8070(52.8) | 1.0(ref) | 1.00 |
> 1.7 | 6513(49.9) | 6527(50.1) | 0.99(0.95–1.03) | 0.58 | 5063(55.0) | 4147(45.0) | 0.91(0.87–0.96) | < 0.01 | 1450(37.9) | 2380(62.1) | 1.47(1.36–1.58) | < 0.01 |
HDL-C(mmol/L) | ||||||||||||
≥ 0.9 | 19,207(49.6) | 19,547(50.4) | 1.00 | 10,733(53.6) | 9292(46.4) | 1.00 | 8474(45.2) | 10,255(54.8) | 1.00 | |||
< 0.9 | 884(53.1) | 780(46.9) | 0.87(0.79–0.96) | < 0.01 | 777(54.5) | 649(45.5) | 0.96(0.87–1.07) | 0.51 | 107(45.0) | 131(55.0) | 1.01(0.78–1.31) | 0.93 |
LDL-C(mmol/L) | ||||||||||||
≤ 3.1 | 11,667(50.6) | 11,410(49.4) | 1.0(ref) | 1.00 | 6008(52.8) | 5372(47.2) | 1.0(ref) | 1.00 | 5659(48.4) | 6038(51.6) | 1.0(ref) | 1.00 |
> 3.1 | 8424(48.6) | 8917(51.4) | 1.08(1.04–1.13) | < 0.01 | 5502(54.6) | 4569(45.4) | 0.93(0.88–0.98) | 0.01 | 2922(40.2) | 4348(59.8) | 1.39(1.31–1.48) | < 0.01 |
HUA(µmol/L) | ||||||||||||
No | 15,802(49.4) | 16,176(50.6) | 1.0(ref) | 1.00 | 8059(53.1) | 7106(46.9) | 1.0(ref) | 1.00 | 7743(46.1) | 9070(53.9) | 1.0(ref) | 1.00 |
Yes | 4415(51.1) | 4217(48.9) | 0.93(0.89–0.98) | < 0.01 | 3495(55.0) | 2859(45.0) | 0.93(0.87–0.98) | 0.01 | 920(40.4) | 1358(59.6) | 1.26(1.15–1.38) | < 0.01 |
Fatty Liver | ||||||||||||
No | 13,884(50.1) | 13,812(49.9) | 1.0(ref) | 1.00 | 6696(53.4) | 5837(46.6) | 1.0(ref) | 1.00 | 7188(47.4) | 7975(52.6) | 1.0(ref) | 1.00 |
Yes | 6101(49.0) | 6341(51.0) | 1.04(1.00-1.09) | 0.04 | 4785(53.9) | 4094(46.1) | 0.98(0.93–1.04) | 0.50 | 1316(36.9) | 2247(63.1) | 1.54(1.43–1.66) | < 0.01 |