Background
Materials and methods
Subjects
Data collection
Case identification
Statistical analysis
Results
Subject classification and characteristics
Childhood Pneumonia | No Childhood Pneumonia |
p Valueb
| |||
---|---|---|---|---|---|
N = 854 (8.4 %) |
N = 9302 (91.6 %) | ||||
DEMOGRAPHIC | |||||
Male gender (%) | 437 | (51.2 %) | 4990 | (53.6 %) | 0.18 |
Mean age, years (SD) | 61.7 | (8.9) | 59.4 | (9.0) | <0.001c
|
Non-Hispanic white (%) | 693 | (81.1 %) | 6073 | (65.3 %) | <0.001 |
SMOKE EXPOSURE | |||||
In-utero smoke exposure (%)a
| 206 | (33.0 %) | 2082 | (30.2 %) | 0.18 |
Lived with smoker in childhood (%)a
| 732 | (85.7 %) | 7618 | (81.9 %) | 0.006 |
Mean age started smoking, years (SD) | 16.5 | (4.4) | 16.9 | (4.7) | 0.06 |
Pack-years of smoking (SD) | 49.8 | (28.4) | 43.7 | (24.6) | <0.001 |
Current smoking (%) | 379 | (44.4 %) | 5011 | (53.9 %) | <0.001 |
PNEUMONIA HISTORY | |||||
Ever had pneumonia (%) | 854 | (100.0 %) | 2979 | (33.9 %) | <0.001 |
Diagnosed with pneumonia by healthcare provider (%)a
| 821 | (96.1 %) | 2920 | (31.4 %) | <0.001 |
Pneumonia childhood age unknown (%) | 378 | (44.3 %) | 0 | (0.0 %) | <0.001 |
Age first pneumonia in years, mean (SD)a
| 7.7 | (4.5) | 42.5 | (15.6) | <0.001 |
Lifetime pneumonia episodes (SD)a
| 3.9 | (4.9) | 2.5 | (3.0) | <0.001 |
Respiratory symptoms and disease
Childhood Pneumonia | No Childhood Pneumonia | Impact of Childhood Pneumoniaa
| |||||
---|---|---|---|---|---|---|---|
N = 687 (8.5 %) |
N = 7364 (91.5 %) | OR | (95 % CI) |
p Valueb
| |||
COPD, GOLD 2-4 | 405 | (59.0 %) | 3267 | (44.4 %) | 1.40 | (1.17, 1.66) | <0.001 |
COPD, GOLD 2-4 + adjusted for childhood asthma | 1.30 | (1.09, 1.55) | 0.003 |
Childhood Pneumonia | No Childhood Pneumonia | Impact of Childhood Pneumoniab
| |||||
---|---|---|---|---|---|---|---|
N = 854 (8.4 %) |
N = 9302 (91.6 %) | OR (95 % CI) or β (SE)c
|
p Valued
| ||||
Chronic bronchitis (%) | 214 | (25.1 %) | 1730 | (18.6 %) | 1.40 | (1.18, 1.66) | <0.001e
|
Number of COPD exacerbations in past year (SD) | 0.65 | (1.2) | 0.36 | (0.9) | 0.18 | (0.03) | <0.001f
|
Had a severe COPD exacerbation in past year (%) | 140 | (16.4 %) | 1063 | (11.4 %) | 1.28 | (1.04, 1.58) | 0.02f
|
Cardiovascular Disease (%)a
| 179 | (21.0 %) | 1455 | (15.6 %) | 1.20 | (1.00-1.44) | 0.047 |
Diagnosed with asthma by healthcare provider (%)a
| 239 | (28.0 %) | 1508 | (16.3 %) | 2.15 | (1.83, 2.53) | <0.001 |
Childhood asthma (%)a
| 137 | (16.0 %) | 586 | (6.3 %) | 3.30 | (2.68, 4.05) | <0.001 |
SGRQ Score, Total (SD)a
| 32.4 | (24.0) | 26.9 | (22.8) | 2.32 | (0.67) | <0.001g
|
MMRC Dyspnea Scale, 0-4 (SD)a
| 1.6 | (1.5) | 1.3 | (1.4) | 0.12 | (0.04) | 0.006g
|
Childhood Pneumonia | No Childhood Pneumonia | Impact of Childhood Pneumoniaa
| |||
---|---|---|---|---|---|
N = 850 (8.4 %) |
N = 9245 (91.6 %) | β | SE |
p Valueb
| |
FEV1 post-BD % predicted (SD) | 69.1 % (25.7) | 77.1 % (25.4) | −6.22 | (0.88) | <0.001 |
FVC post-BD % predicted (SD) | 82.7 % (18.6) | 87.4 % (18.3) | −3.89 | (0.65) | <0.001 |
FEV1/FVC post-BD (SD) | 0.63 (0.17) | 0.67 (0.16) | −0.02 | (0.005) | <0.001c
|
Impact of Childhood Pneumoniab
| |||
---|---|---|---|
βc
| SE |
p Valued
| |
Wall Area %, Segmental | 0.46 | (0.12) | <0.001 |
Wall Area %, Subsegmentala
| 0.47 | (0.16) | 0.003 |
SRWA-Pi10 | 0.02 | (0.005) | <0.001 |
Emphysema % (-950 HU) | 0.18 | (0.32) | 0.57 |
Gas Trapping %, expiratory scan (-856HU) | 1.97 | (0.72) | 0.006 |
Total Lung Capacity (L) | 0.001 | (0.04) | 0.99 |