Background
Distinct DNA methylation patterns identified in AML
DNA methylation in diagnosis classification of AML
DNA methylation in prognostic stratification of AML
Reference | DNA methylation detection methods | AML group | Prognostic genes regulated by DNA methylation |
---|---|---|---|
Figueroa et al. [16] | HELP | 344 Newly diagnosed AML |
BLR1 (CXCR5), BTBD3, E2F1, FAM110A, FAM30A, GALNT5, KIAA1305, LCK, LMCD1, PRMT7, SLC7A6OS, SMG6, SRR, USP50, VWF, ZFP161
|
Li et al. [9] | ERRBS | 138 Paried AML (diagnosis and relapse) |
CCDC85C, CHL1, ELAVL2, FAM115A, FAM196A, GPR146, GPR6, HELZ2, ID4, IL2RA, KCNG3, LOC254559, LOC284801, NPAS2, PCDHAC2, PROB1, SHISA6, SLC18A3, SOCS2, TRIM67, ZFP42
|
Marcucci et al. [50] | MethylCap-seq | 134 CN-AML (355 CN-AML validated) |
AATK, ACAP3, ADCK2, ADCY6, AGPAT9, AHCY, ALOX15B, ANXA6, APBB1, APOD, AQP11, ARHGAP27, AXL, BRF1, C15orf62, C17orf77, C8orf51, CABLES1, CARD11, CD34
a
, CHMP7, CISH, CLDN15, CLEC3B, DDIT4, DHCR24, DHRS12, EGFL7, ETS1, EVC, F2RL1
a
, FAM92A1
a
, FCHO1, FKBP4, FLVCR1, FLVCR1-AS1, FZD6, GAL3ST3, GCNT2, GIT1, GPR56, H1F0, HCN2, HIVEP3, IQSEC1, KCNK6, KDM2B, KLHL3, KNCN, LOC646627, MDFI, ME3, MEOX1, MIR126, MIR155HG
a
, MVD, NAV1, NBL1, NLRP1, PLK3, PMM1, PRKCZ, PRKG2, RAB36, RGS3, RHOC
a
, RHPN1, SCARF1, SCRN1
a
, SH3TC1, SPRY1, SRC, TBL2, TCEA3, TENC1, UBXN6, VWA8
a
, WDR16, WDR86, WRAP53, ZNF623, ZNF70
|
DNA methylation in therapeutic decision-making of AML
Compound | Target | Phase | Registration number | Reference |
---|---|---|---|---|
IDH305 | IDH1 | 1 | NCT02381886 | 83 |
AG120 | IDH1 | 1 | NCT02074839 | 84 |
AG120 | IDH1 | 1 | NCT02073994 | 82 |
AG221 | IDH2 | 1/2 | NCT01915498 | 86 |
AG221 | IDH2 | 1/2 | NCT02273739 | NA |
AG221 | IDH2 | 3 | NCT02577406 | NA |
AG-120/AG-221 | IDH1/IDH2 | 1 | NCT02632708 | NA |
AG-120/AG-221 | IDH1/IDH2 | 1b/2 | NCT02677922 | NA |