Introduction
Methods
Study population
Erythrocyte suspensions
Nickel mesh filter
Erythrocyte filterability
Erythrocyte shape
Data analyses
Results
Patient profiles
Hypertensive group (n = 101) | Normotensive group (n = 14) |
p value | |
---|---|---|---|
Age (years) | 66.6 ± 10.7 | 64.2 ± 4.4 | 0.421 |
Gender (female/male) | 41 / 60 | 6 / 8 | 0.872 |
BMI (kg/m2) | 23.5 ± 3.0 | 22.6 ± 3.4 | 0.258 |
Current smoker (%) | 29 (28.7) | 3 (21.4) | 0.754 |
HbA1c (NGSP) (%) | 5.2 ± 0.5 | 5.2 ± 0.3 | 0.547 |
Total cholesterol (mg/dL) | 203.2 ± 36.8 | 202.1 ± 35.5 | 0.918 |
HDL cholesterol (mg/dL) | 58.2 ± 15.1 | 62.0 ± 11.5 | 0.364 |
LDL cholesterol (mg/dL) | 111.1 ± 29.6 | 125.1 ± 34.3 | 0.105 |
Triglyceride (mg/dL) | 139.7 ± 100.7 | 110.7 ± 72.0 | 0.301 |
Systolic BP (mmHg) | 143.2 ± 18.9 | 125.1 ± 15.5 | <0.001 |
Diastolic BP (mmHg) | 81.0 ± 11.3 | 72.0 ± 3.3 | 0.004 |
Hb (g/dL) | 14.0 ± 1.8 | 13.4 ± 1.1 | 0.189 |
Ht (%) | 40.4 ± 4.5 | 38.7 ± 2.9 | 0.184 |
MCV (fl) | 93.8 ± 4.7 | 91.7 ± 3.8 | 0.110 |
MCH (pg) | 32.6 ± 1.9 | 34.6 ± 0.8 | 0.651 |
MCHC (g/dL) | 34.7 ± 1.0 | 31.7 ± 1.5 | 0.109 |
Erythrocyte filterability (%) | 87.8 ± 2.2 | 89.4 ± 1.7 | 0.010 |
Erythrocyte filterability
Correlation between BP and filterability
Continuous parameters | Correlation coefficient |
p value |
BMI (kg/m2) | 0.161 | 0.109 |
HbA1c (NGSP) (%) | 0.140 | 0.163 |
Total cholesterol (mg/dL) | 0.076 | 0.450 |
Mean BP (mmHg) | −0.303 | 0.002 |
Discrete parameters |
n
|
p value |
Atrial fibrillation | 11 | 0.060 |
Current smoker | 29 | 0.864 |
Stroke episode | 12 | 0.211 |
Coronary artery disease | 15 | 0.821 |
Covariate | Variance inflation factor |
t value |
p value |
---|---|---|---|
BMI (kg/m2) | 1.001 | 1.503 | 0.136 |
HbA1c (NGSP) (%) | 1.017 | 0.401 | 0.689 |
Total cholesterol (mg/dL) | 1.006 | 1.499 | 0.137 |
Mean BP (mmHg) | 1.000 | −3.431 | 0.001 |
Atrial fibrillation | 1.044 | 1.143 | 0.256 |
Stroke episode | 1.004 | −1.498 | 0.137 |
Tertile | Systolic BP | Diastolic BP | Erythrocyte filterability |
p value |
---|---|---|---|---|
(n) | (mmHg) | (mmHg) | (%) | |
First (34) | 160.7 ± 12.3 | 92.9 ± 6.9 | 87.0 ± 2.1 | |
Second (34) | 145.3 ± 9.4 | 79.7 ± 6.3 | 87.9 ± 2.3 | 0.009 |
Third (33) | 122.4 ± 9.6 | 69.8 ± 5.5 | 88.6 ± 2.1 |