01.08.2008 | Adis Drug Profile
Fentanyl Transdermal Matrix Patch (Durotep® MT Patch; Durogesic® DTrans®; Durogesic® SMAT)
In Adults with Cancer-Related Pain
Erschienen in: Drugs | Ausgabe 12/2008
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▲ The fentanyl transdermal matrix patch is approved in Japan for the management of moderate to severe cancer-related pain in adults.
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▲ Bioequivalence, in terms of exposure and the maximum and minimum serum concentrations, has been established between the fentanyl transdermal matrix patch 16.8 mg (100 μg/h) and the fentanyl transdermal reservoir patch 10 mg (100 μg/h) after single and multiple applications.
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▲ The fentanyl transdermal matrix patch 2.1–8.4 mg (12.5-50 μg/h) effectively managed chronic cancer-related pain in adults in a noncomparative, multi-centre, phase II study; 89.4% of recipients rated their global assessment of pain as ‘very satisfied’, ‘satisfied’ or ‘neither satisfied nor dissatisfied’.
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▲ Adults with cancer- or non-cancer-related chronic pain were switched from fentanyl transdermal reservoir patch to fentanyl transdermal matrix patch therapy without compromising efficacy; no differences in pain intensity or sleep interference scores were seen between the two formulations in an nonblind, multicentre, switching pilot study.
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▲ Given the nature of the therapy, the tolerability profile of the fentanyl transdermal matrix patch was generally acceptable. Topical adverse events included erythema, application-site irritation and pruritus. In general, patients and physicians preferred the fentanyl transdermal matrix patch over the fentanyl transdermal reservoir patch in the pilot study.