Introduction
Methods
2018–2019 | 2020–2021 | 2021–2022 | 2022–2023 | p | |
---|---|---|---|---|---|
N | 1618 | 121 | 1577 | 2014 | |
Age, months | 3.0 [1.0–5.0] | 5.6 [1.5–9.0] | 2.0 [1.0–4.3] | 2.5 [1.0–5.5] | < 0.001 |
Age > 12 months | 96 (5.9) | 23 (19) | 77 (4.9) | 140 (7.0) | < 0.001 |
Sex | |||||
Female | 683 (42) | 36 (30) | 707 (45) | 849 (42) | 0.009 |
Male | 935 (58) | 85 (70) | 870 (55) | 1165 (58) | |
Cases before autumn–winter seasona | 24 (1.5) | 25 (20) | 25 (1.6) | 38 (1.9) | < 0.001 |
Number of older siblings | 1 [1-1] | 1 [0–1] | 1 [1-1] | 1 [1-1] | 0.012 |
Maternal COVID-19 during pregnancy | 0 (0.0) | 2 (2.3) | 20 (1.8) | 63 (5.8) | < 0.001 |
Neonatal gestational age, weeks | 38.2 (± 2.7) | 37.6 (± 3.2) | 38.2 (± 2.7) | 38.2 (± 2.6) | 0.124 |
Neonatal body weight, grams | 3101 (± 656) | 2957 (± 779) | 3137 (± 657) | 3117 (± 635) | 0.043 |
Breastfeeding | 970 (76) | 64 (69) | 1040 (76) | 1261 (78) | 0.099 |
Length of exclusive breastfeeding, months | 2.0 [1.0–4.0] | 1.5 [0.0–5.0] | 1.5 [1.0–3.1] | 2.0 [1.0–4.0] | 0.057 |
Chronic disease | 105 (6.5) | 16 (13) | 126 (8.0) | 124 (6.2) | 0.006 |
Bronchopulmonary dysplasia | 20 (1.2) | 5 (4.1) | 21 (1.3) | 25 (1.2) | 0.059 |
Congenital heart disease | 11 (0.7) | 2 (1.7) | 27 (1.7) | 19 (0.9) | 0.032 |
Further | 74 (4.6) | 9 (7.4) | 78 (4.9) | 80 (4.0) | 0.201 |
Radiologically confirmed pneumonia | |||||
Yes | 292 (18) | 14 (12) | 277 (18) | 322 (16) | 0.152 |
No | 509 (32) | 50 (41) | 495 (31) | 480 (24) | |
Rx not performed | 814 (50) | 57 (47) | 805 (51) | 1180 (60) | |
Etiologic agent | |||||
Respiratory syncytial virus | 897 (56) | 8 (6.6) | 1120 (71) | 1267 (63) | < 0.001 |
Other infectious agents | 271 (17) | 63 (52) | 184 (12) | 321 (16) | |
No agent identified | 450 (28) | 50 (41) | 273 (17) | 426 (21) |
Statistical analysis
Results
2018–2019 | 2020–2021 | 2021–2022 | 2022–2023 | p | |
---|---|---|---|---|---|
N | 1618 | 121 | 1577 | 2014 | |
Oxygen supplementation | 959 (59) | 69 (57) | 1157 (73) | 1527 (76) | < 0.001 |
Length of oxygen supplementation, days | 0 [0–4] | 1 [0–3] | 2 [0–5] | 2 [0–5] | < 0.001 |
Non-invasive ventilation support | 470 (29) | 42 (35) | 726 (46) | 1055 (52) | < 0.001 |
Invasive ventilation support | 20 (1.2) | 1 (0.8) | 18 (1.1) | 39 (1.9) | 0.159 |
Intensive care unit admission | 178 (11) | 13 (11) | 239 (15) | 320 (16) | < 0.001 |
Length of intensive care stay, days | 5 [3-7] | 3 [2-6] | 5 [3-7] | 5 [4-8] | < 0.001 |
Length of intensive care stay ≥ 3, days | 143 (80) | 8 (62) | 192 (80) | 285 (89) | 0.001 |
Extracorporeal membrane oxygenation | 3 (0.2) | 0 (0.0) | 1 (0.1) | 2 (0.1) | 0.735 |
Length of the whole hospitalization, days | 6 [4-8] | 5 [4-6] | 6 [4-8] | 6 [4-8] | < 0.001 |
Length of the whole hospitalization ≥ 4 days | 1352 (84) | 91 (75) | 1343 (85) | 1758 (87) | < 0.001 |
Outcome | Study periods | Odds ratio | Lower 95% confidence interval | Upper 95% confidence interval | p |
---|---|---|---|---|---|
Need for oxygen supplementation | 2020–21 | 0.701 | 0.390 | 1.258 | 0.233 |
2021–22 | 1.649 | 1.289 | 2.109 | < 0.001 | |
2022–23 | 2.205 | 1.685 | 2.885 | < 0.001 | |
Need for non-invasive ventilation support | 2020–21 | 1.642 | 0.858 | 3.145 | 0.134 |
2021–22 | 2.185 | 1.687 | 2.831 | < 0.001 | |
2022–23 | 3.643 | 2.752 | 4.824 | < 0.001 | |
Need for invasive ventilation support | 2020–21 | 2.175 | 0.241 | 19.618 | 0.489 |
2021–22 | 0.592 | 0.225 | 1.555 | 0.287 | |
2022–23 | 1.514 | 0.651 | 3.523 | 0.336 | |
Need for intensive care unit admission | 2020–21 | 1.461 | 0.565 | 3.781 | 0.434 |
2021–22 | 1.331 | 0.931 | 1.903 | 0.117 | |
2022–23 | 1.306 | 0.883 | 1.931 | 0.181 |
Outcome | Study periods | ß | Lower 95% confidence interval | Upper 95% confidence interval | p |
---|---|---|---|---|---|
Length of intensive care unit stay | 2020–21 | 0.194 | -0.468 | 0.856 | 0.565 |
2021–22 | 0.035 | -0.224 | 0.293 | 0.793 | |
2022–23 | 0.101 | -0.175 | 0.377 | 0.474 | |
Length of oxygen supplementation | 2020–21 | -0.637 | -1.429 | 0.155 | 0.115 |
2021–22 | 0.750 | 0.441 | 1.059 | < 0.001 | |
2022–23 | 1.121 | 0.793 | 1.450 | < 0.001 | |
Whole duration of hospital stay | 2020–21 | -0.110 | -1.068 | 0.849 | 0.822 |
2021–22 | -0.060 | -0.440 | 0.319 | 0.754 | |
2022–23 | 0.637 | 0.233 | 1.042 | 0.002 |