Introduction
Results
PVT1 expression is increased in human gastric cancer tissues and correlates with poor prognosis
Clinical parameter
|
PVT1
|
Chi-squared test P-value
| |
---|---|---|---|
High no. cases
|
Low no. cases
| ||
Age (years)
|
0.370
| ||
<50
|
23
|
19
| |
>50
|
17
|
21
| |
Gender
|
0.361
| ||
Male
|
26
|
22
| |
Female
|
14
|
18
| |
Location
|
0.841
| ||
Distal
|
17
|
15
| |
Middle
|
15
|
15
| |
Proximal
|
8
|
10
| |
Histologic differentiation
|
0.206
| ||
Well
|
3
|
2
| |
Moderately
|
9
|
18
| |
Poorly
|
23
|
16
| |
Undifferentiated
|
5
|
4
| |
Invasion depth
|
0.002*
| ||
T1
|
5
|
14
| |
T2
|
7
|
15
| |
T3
|
14
|
6
| |
T4
|
14
|
5
| |
TNM Stages
|
0.015*
| ||
I
|
2
|
9
| |
II
|
12
|
18
| |
III
|
22
|
12
| |
IV
|
4
|
1
| |
Lymphatic metastasis
|
0.179
| ||
Yes
|
24
|
18
| |
No
|
16
|
22
| |
Distant metastasis
|
0.116
| ||
Yes
|
4
|
0
| |
No
|
36
|
40
|
Variables
|
DFS
|
OS
| ||||
---|---|---|---|---|---|---|
HR
|
95% CI
|
p value
|
HR
|
95% CI
|
p value
| |
Univariate analysis
| ||||||
Age (<50 years vs. >50 years)
|
0.830
|
0.448-1.536
|
0.552
|
0.854
|
0.462-1.581
|
0.616
|
Gender (male vs. female)
|
0.716
|
0.378-1.354
|
0.304
|
0.686
|
0.362-1.299
|
0.247
|
Location (Distal vs. Middle + Proximal)
|
0.711
|
0.383-1.322
|
0.281
|
0.668
|
0.359-1.241
|
0.201
|
Histologic differentiation (Well + Moderately vs. Poorly + Undifferentiated)
|
1.204
|
0.642-2.257
|
0.562
|
1.198
|
0.639-2.246
|
0.572
|
Invasion depth (T1 + T2 vs. T3 + T4)
|
0.629
|
0.370-1.069
|
0.087
|
0.863
|
0.466-1.597
|
0.639
|
TNM stage (I + II vs. III + IV)
|
0.377
|
0.198-0.720
|
0.003*
|
0.396
|
0.209-0.750
|
0.004*
|
Lymphatic metastasis (Yes vs. No.)
|
0.917
|
0.674-1.247
|
0.581
|
0.920
|
0.677-1.251
|
0.596
|
Regional lymph nodes (PN2+ PN3 vs. PN0+ PN1)
|
1.717
|
0.901-3.271
|
0.192
|
1.668
|
0.878-3.169
|
0.118
|
Distant metastasis (No vs. Yes)
|
0.255
|
0.073-0.892
|
0.032*
|
0.191
|
0.054-0.679
|
0.011*
|
Expression of
PVT1
(High vs. Low)
|
2.691
|
1.418-5.109
|
0.002*
|
2.612
|
1.381-4.942
|
0.003*
|
Multivariate analysis
| ||||||
TNM stage (I + II vs. III + IV)
|
0.457
|
0.233-0.897
|
0.023*
|
0.496
|
0.254-0.970
|
0.040*
|
Lymphatic metastasis (No vs. Yes)
|
NA
|
NA
| ||||
Regional lymph nodes (PN0+ PN1 vs. PN2+ PN3)
|
NA
|
NA
| ||||
Distant metastasis (No vs. Yes)
|
0.525
|
0.145-1.899
|
0.326
|
0.371
|
0.101-1.361
|
0.135
|
Expression of
PVT1
(High vs. Low)
|
2.216
|
1.130-4.345
|
0.021*
|
2.092
|
1.068-4.096
|
0.031*
|