Ludwig’s angina

Patients with Ludwig’s angina require urgent evaluation for airway obstruction due to elevation and posterior displacement of the tongue. Emergency physicians should remember that risks of laryngospasm preclude blind oral or nasotracheal intubation.

A 54-year-old female presented to the emergency department (ED) with right-sided facial pain, subjective fever, and chills for 1 week. Physical examination revealed right-sided facial swelling, trismus, tongue elevation (Fig. 1), submandibular and sublingual swelling, and tenderness with adenopathy. Computed tomography (CT) findings were (Fig. 2) consistent with Ludwig’s angina. The patient was treated with dexamethasone and clindamycin, and taken for surgical decompression and tooth extraction then discharged home. Pathological analysis showed polymicrobial flora including Staphylococcus aureus, Eikenella corrodens, Clostridium clostridiforme, and Prevotella buccae.

Ludwig’s angina, a rapidly progressive cellulitis of the floor of the mouth, involves the submandibular, submaxillary, and sublingual spaces. Patients have swelling, pain, and elevation of the tongue, malaise, fever, neck swelling, and dysphagia. The submandibular area can be indurated, sometimes with palpable crepitus. Inability to swallow saliva and stridor raise concern because of imminent airway compromise. The most feared complication is airway obstruction due to elevation and posterior displacement of the tongue. The mortality rate for Ludwig’s angina is currently below 8% down from the preantibiotic numbers over 50% [1].

Nasal fiberoptic evaluation should be performed with imminent airway obstruction. Securing the airway by blind oral or nasotracheal intubation is contraindicated because of the risk of laryngospasm. Diagnostic sensitivity of clinical examination alone is 55%. In less urgent cases, contrast-enhanced CT may increase this to 95% [2]. Immunocompetent patients should receive ampicillin-sulbactam, with clindamycin reserved for penicillin-allergic patients. Immunocompromised patients require empiric broad-spectrum antibiotics. Any source of infection should be removed. Needle drainage can be performed to reduce the risk of spreading infection [3].