nach oben

Clinical & Experimental Metastasis

Erschienen in:

01.08.2010 | Research Paper

Lung cancer progression and metastasis from the prognostic point of view

verfasst von: Kentaro Inamura, Yuichi Ishikawa

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 6/2010

Einloggen, um Zugang zu erhalten

Abstract

Lung cancer is the leading cause of cancer death in men and women worldwide. Since the occurrence of metastases in distant organs is the major reason for mortality of cancer patients, we need to elucidate the underlying mechanisms. Many studies featuring analysis of gene expression, comparative genomic hybridization and loss of heterozygosity analysis have been performed and generated support for the hypothesis that metastatic potential is acquired early in tumorigenesis. Furthermore, it is now clear that the majority of tumor cells have the potential to metastasize. Although many changes in gene expression profiles have been established retrospectively, translational research is now a high priority to enable clinical application and treatment based on laboratory findings.

Brundage MD, Davies D, Mackillop WJ (2002) Prognostic factors in non-small cell lung cancer: a decade of progress. Chest 122(3):1037–1057. doi:10.1378/chest.122.3.1037 CrossRefPubMed

Miyoshi T, Satoh Y, Okumura S et al (2003) Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis. Am J Surg Pathol 27(1):101–109. doi:10.1097/00000478-200301000-00011 CrossRefPubMed

Inamura K, Shimoji T, Ninomiya H et al (2007) A metastatic signature in entire lung adenocarcinomas irrespective of morphological heterogeneity. Hum Pathol 38(5):702–709. doi:10.1016/j.humpath.2006.11.019 CrossRefPubMed

Garber ME, Troyanskaya OG, Schluens K et al (2001) Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci USA 98(24):13784–13789. doi:10.1073/pnas.241500798 CrossRefPubMed

Bhattacharjee A, Richards WG, Staunton J et al (2001) Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA 98(24):13790–13795. doi:10.1073/pnas.191502998 CrossRefPubMed

Beer DG, Kardia SL, Huang CC et al (2002) Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med 8(8):816–824PubMed

Ramaswamy S, Ross KN, Lander ES et al (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33(1):49–54. doi:10.1038/ng1060 CrossRefPubMed

Liotta LA, Kohn EC (2003) Cancer’s deadly signature. Nat Genet 33(1):10–11. doi:10.1038/ng0103-10 CrossRefPubMed

Potti A, Mukherjee S, Petersen R et al (2006) A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N Engl J Med 355(6):570–580. doi:10.1056/NEJMoa060467 CrossRefPubMed

10.

Sun Z, Aubry MC, Deschamps C et al (2006) Histologic grade is an independent prognostic factor for survival in non-small cell lung cancer: an analysis of 5018 hospital- and 712 population-based cases. J Thoracic Cardiovasc Surg 131(5):1014–1020. doi:10.1016/j.jtcvs.2005.12.057 CrossRef

11.

Inamura K, Fujiwara T, Hoshida Y et al (2005) Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization. Oncogene 24(47):7105–7113. doi:10.1038/sj.onc.1208858 CrossRefPubMed

12.

Brunet JP, Tamayo P, Golub TR et al (2004) Metagenes and molecular pattern discovery using matrix factorization. Proc Natl Acad Sci USA 101(12):4164–4169. doi:10.1073/pnas.0308531101 CrossRefPubMed

13.

Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC (2004) World health organization classification of tumours: pathology and genetics of tumours of the lung, pleural, thymus and heart. Springer, Berlin

14.

Jones MH, Virtanen C, Honjoh D et al (2004) Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles. Lancet 363(9411):775–781. doi:10.1016/S0140-6736(04)15693-6 CrossRefPubMed

15.

Virtanen C, Ishikawa Y, Honjoh D et al (2002) Integrated classification of lung tumors and cell lines by expression profiling. Proc Natl Acad Sci USA 99(19):12357–12362. doi:10.1073/pnas.192240599 CrossRefPubMed

16.

Sasatomi E, Finkelstein SD, Woods JD et al (2002) Comparison of accumulated allele loss between primary tumor and lymph node metastasis in stage II non-small cell lung carcinoma: implications for the timing of lymph node metastasis and prognostic value. Cancer Res 62(9):2681–2689PubMed

17.

Kang Y, Siegel PM, Shu W et al (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3(6):537–549. doi:10.1016/S1535-6108(03)00132-6 CrossRefPubMed

18.

Kakiuchi S, Daigo Y, Tsunoda T et al (2003) Genome-wide analysis of organ-preferential metastasis of human small cell lung cancer in mice. Mol Cancer Res 1(7):485–499PubMed

19.

van ‘t Veer LJ, Dai H, van de Vijver MJ et al (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 415(6871):530–536. doi:10.1038/415530a CrossRefPubMed

20.

Terasaki H, Niki T, Matsuno Y et al (2003) Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization. Am J Surg Pathol 27(7):937–951. doi:10.1097/00000478-200307000-00009 CrossRefPubMed

21.

Segara D, Biankin AV, Kench JG et al (2005) Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia. Clin Cancer Res 11(9):3587–3596. doi:10.1158/1078-0432.CCR-04-1813 CrossRefPubMed

22.

Kikuchi T, Daigo Y, Katagiri T et al (2003) Expression profiles of non-small cell lung cancers on cDNA microarrays: identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs. Oncogene 22(14):2192–2205. doi:10.1038/sj.onc.1206288 CrossRefPubMed

23.

D’Arrigo A, Belluco C, Ambrosi A et al (2005) Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. Int J Cancer 115(2):256–262. doi:10.1002/ijc.20883 CrossRefPubMed

24.

Xi L, Lyons-Weiler J, Coello MC et al (2005) Prediction of lymph node metastasis by analysis of gene expression profiles in primary lung adenocarcinomas. Clin Cancer Res 11(11):4128–4135. doi:10.1158/1078-0432.CCR-04-2525 CrossRefPubMed

25.

Ein-Dor L, Zuk O, Domany E (2006) Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer. Proc Natl Acad Sci USA 103(15):5923–5928. doi:10.1073/pnas.0601231103 CrossRefPubMed

26.

Miyazaki YJ, Hamada J, Tada M et al (2002) HOXD3 enhances motility and invasiveness through the TGF-beta-dependent and -independent pathways in A549 cells. Oncogene 21(5):798–808. doi:10.1038/sj.onc.1205126 CrossRefPubMed

27.

Inamura K, Togashi Y, Okui M et al (2007) HOXB2 as a novel prognostic indicator for stage I lung adenocarcinomas. J Thoracic Oncol 2(9):802–807. doi:10.1097/JTO.0b013e3181461987 CrossRef

Titel: Lung cancer progression and metastasis from the prognostic point of view
verfasst von: Kentaro Inamura
Yuichi Ishikawa
Publikationsdatum: 01.08.2010
Verlag: Springer Netherlands
Erschienen in: Clinical & Experimental Metastasis / Ausgabe 6/2010
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI: https://doi.org/10.1007/s10585-010-9313-4

Neu im Fachgebiet Onkologie

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Springer Medizin

Lung cancer progression and metastasis from the prognostic point of view

Abstract

Neu im Fachgebiet Onkologie

Umsetzung der POMGAT-Leitlinie läuft

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

Sind Frauen die fähigeren Ärzte?

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2010

Similar expression profiles of a core of genes and proteins in cells that have acquired a metastatic phenotype, genetically or by in vivo evolution

Proteomic strategies and challenges in tumor metastasis research

Childhood rhabdomyosarcoma metastatic to bone marrow presenting with disseminated intravascular coagulation and acute tumour lysis syndrome: review of the literature apropos of two cases

Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs

Genomics of metastatic progression

Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?

Neu im Fachgebiet Onkologie

Umsetzung der POMGAT-Leitlinie läuft

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

Sind Frauen die fähigeren Ärzte?

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Onkologie