Background
Methods
Literature search
Study identification
Data extraction and synthesis
Results
Study selection
Study characteristics
Post-transplant survival
Data source | Yr. of transplant | No. of IPF patients | % of patients alive (95% confidence interval) | ||||
---|---|---|---|---|---|---|---|
3 mo. | 1 yr. | 3 yr. | 5 yr. | 10 yr. | |||
ISHLT data
| |||||||
1990 – 2011 | 8,528 | 85 | 75 | 59 | 47 | 24 | |
OPTN data
| |||||||
OPTN website [19] | 1997 – 2004a
| 1,271b
| NR | 80 (77, 83) | 57 (53, 61) | 41 (36, 44) | NR |
2011 Annual Report [11] | 2005 – 2006 | 755 | 91 | 81 | 64 | 53 | NR |
Analysis of OPTN data (Meyer, et al) [20] | 1988 – 1997 | NR | NR | NR | NR | 32.1 ± 2.4% (mean±SE) | NR |
Analysis of OPTN data (Thabut, et al) [21] | 1987 – 2009 | 3,327 | NR | 76 (75, 78) | 59 (57, 61) | 44 (42, 46) | NR |
Analysis of OPTN data (Edwards, et al)[22] | 1996 – 2001 | 786 | NR | ~68c
| ~50c
| ~39c
| NR |
Analysis of OPTN data (McCurry, et al) [23] | 2001 – 2006 | 1,636 | NR | NR | NR | 49 | NR |
Analysis of OPTN data (Chen, et al) [24] | 2002 – 2005 | 1,418 | NR | ~79 (~75, ~82)c
| NR | NR | NR |
2005 – 2008 | 1,563 | NR | ~80 (~78, ~83)c
| NR | NR | NR | |
Analysis of OPTN data (Freitas, et al) [25] | 1987 – 2009 | 4,205 | NR | 77d
| 58d
| 44d
| NR |
OPTN and Loyola University Medical Center databases [26] | 1991 – 2009 | 4,190 | NR | 78 | 61 | 47 | NR |
Other registries and large databases
| |||||||
Spanish Lung Transplant Registry (Coll, et al) [27] | 2006 – 2010 | 261 | ~80c
| ~63c
| NR | NR | NR |
Nationwide Inpatient Sample, US (Teo, et al) [28] | 1988 – 2006 | 231 | In-hospital: 91 | NR | NR | NR | NR |
Single center studies in Europe, Brazil and Australia
| |||||||
Single center in Denmark (Burton, et al) [29] | 1992 – 2004 | 21 | 76 | NR | 52 | NR | |
2000 – 2009 | 84 | NR | 83 | 61 | 41 | NR | |
1996 – 2002 | 23 | 95.7 | NR | NR | NR | NR | |
Papworth Hospital, England (McNeil, et al) [32] | 1984 – 1994 | 11 | 46 | NR | NR | NR | NR |
Hopital Beaujon, France (Thabut, et al) [33] | 1988 – 2001 | 28 | 30 day: 93 | 79 | 2 yr: 64 | 39 | NR |
University of Munich, Germany (Neurohr, et al) [34] | 1997 – 2008 | 76 | 87 | 74 | 65 | 53 | 7.5 yrs: 40 |
University of Cordoba, Spain (Algar, et al) [35] | 1993 – 2009 | 89 | NR | 53 | 40 | 33 | |
Santa Casa de Misericordia de Porto Alegre, Brazil (Machuca, et al) [36] | 2004 – 2009 | 53 | NR | 72 | NR | NR | NR |
Alfred Hospital, Melbourne, Australia (Keating, et al) [37] | 1990 – 2008 | 67 | NR | 76 | NR | 50 | 34 |
Single center studies in North America
| |||||||
University of Pittsburgh, US (DiGiuseppe, et al) [38] | 1986 – 2007 | 78 | NR | NR | 50 | ~32c
| |
Two centers (Johns Hopkins Hospital and the University of Pittsburgh Medical Center), US (Schachna, et al) [39] | 1989 – 2002 | 70 | 6-month: 80 | 2-year: 67 | NR | NR | NR |
University of Pennsylvania, US (Rivera-Lebron, et al) [40] | 2005 – 2010 | 68 | NR | 78 | NR | 52 | NR |
Washington University School of Medicine, St Louis, Mo, US (Meyers, et al) [41] | 1988 –1998 | 45 | NR | 76 | NR | 54 | NR |
University of California, Los Angeles, US (Saggar, et al) [42] | 2003 – 2007 | 38 | NR | 87 | NR | NR | NR |
Vanderbilt University Medical Center, US (Milstone, et al) [43] | 1990 – 1998 | 32 | NR | 25 | NR | NR | NR |
University of Virginia, US (Smith, et al) [44] | 1995 – 2005 | 27 | 30 day: <60 yrs: 100; ≥60 yrs: 93 (79, 100) | <60 yrs: 85 (65, 100) ≥ 60 yrs: 93 (79, 100) | <60 yrs: 68 (42, 94) ≥ 60 yrs: 93 (79, 100) | <60 yrs: 48 (19, 78) ≥60 yrs: 58 (26, 90) | NR |
University of Alabama, US (Wille, et al) [45] | 1994 – 2004 | 48 | 87 | 80 | 67 | 47 | NR |
Washington University/Barnes Hospital (Davis, et al) [46] | 1998 – 1993 | 16 | In-hospital: 87 | 72 | 62 | NR | NR |
Toronto Lung Transplant Group, Canada (Grossman, et al) [47] | 1983 – 1989 | 16 | NR | 63 | NR | NR | NR |
Cleveland Clinic, US (Mason, et al) [48] | 1990 – 2005 | 82 | 30-day: 95 | 73 | 56 | 44 | 7-year: 36 |
1993 – 2009 | 79 | In-hospital: 94 | 82 | 63 | 63 | NR |
Single vs. bilateral lung transplantation
Data source | Yr. of transplant | No. of IPF patients | Survival (% IPF patients alive) | ||||
---|---|---|---|---|---|---|---|
Median survival | 1 yr. | 3 yr. | 5 yr. | 10 yr. | |||
ISHLT, OPTN, and Eurotransplant data
| |||||||
ISHLT data [12] | 1990 - 2011 | 8,528 | NR | SLT: 75 BLT: 74 | SLT: 57 BLT: 63 | SLT: 43 BLT: 49 | SLT: 20 BLT: 35 |
Analysis of OPTN data (Force, et al) [51] | 1987 - 2008 | 3,830 | NR | NR | NR | SLT ~53a
| SLT ~30a;
|
BLT: 60a
| BLT: ~48a
| ||||||
Analysis of OPTN data (Thabut et al) [21] | 1987 - 2009 | 3,327 | SLT: 5.2 years (4.3–6.7); BLT: 3.8 years (3.6–4.1) | NR | NR | NR | NR |
Analysis of OPTN data (Nwakanma, et al) [52] | 1998 - 2004 | 429 | 30-day SLT: 94 | SLT: 69 | SLT: 52 | SLT: 33 | NR |
BLT: 95 | BLT: 72 | BLT: 54 | BLT: 54 | ||||
Eurotransplant (Smits et al) [53] | 1997 - 1999 | 104 | NR | NR | SLT: 63 | NR | NR |
BLT: 47 | |||||||
Single center studies
| |||||||
1993 - 2009 | 79 | NR | SLT: 82 | SLT: 65 | SLT: 65 | SLT: 49 | |
BLT: 86 | BLT: 55 | BLT: 55 | BLT: 55 | ||||
Cleveland Clinic, US (Mason, et al) [48] | 1990 - 2005 | 82 | NR | SLT: 67 | NR | SLT: 34 | NR |
BLT: 81 | BLT: 55 | ||||||
Alfred Hospital, Melbourne, Australia (Keating, et al) [37] | 1990 - 2008 | 67 | NR | SLT: 78 | NR | SLT: 49 | SLT: 29 |
BLT: 68 | BLT: 50 | BLT: 50 | |||||
University of Munich, Germany (Neurohr, et al) [34] | 1997 - 2008 | 76 | SLT: 83 | SLT: 70 | SLT: 55 | SLT: 42 | NR |
BLT: 93 | BLT: 80 | BLT: 74 | BLT: 67 |
Post-transplant survival vs. wait list survival
Obstructive lung disease1
| Pulmonary vascular disease2
| Cystic fibrosis and immunodeficiency disorders | Idiopathic pulmonary fibrosis and re-transplant | |
---|---|---|---|---|
1998-99 | 10.8 | 17.2 | 21.6 | 32.1 |
2000-01 | 9.7 | 13.1 | 17.8 | 23.1 |
2002-03 | 8.7 | 10.6 | 14.8 | 22.1 |
2004-05 | 7.7 | 7.3 | 14.4 | 19.9 |
2006-07 | 6.9 | 8.7 | 10.7 | 19.2 |
2008-09 | 5.5 | 14.2 | 15.3 | 22.5 |
2010-11 | 6.7 | 19.9 | 15.5 | 26.9 |
No. of IPF patients | % died on wait list | |
---|---|---|
OPTN data, IPF patients on the lung transplant list between January 1995 and December 2000 [60] | 2,115 | 31% |
IPF patients, recorded in the OPTN database between June 30, 2004 and July 22, 2005, with 6-months of follow-up who did not undergo lung transplantation [61] | 209 | 23% |
IPF patients on the wait list at the University of California San Diego from January 1990 to February 1999 [62] | 25 | 28% |
IPF patients awaiting lung transplantation in five institutions and listed in The Korean Network for Organ Sharing (KONOS) from May 1996 to May 2011 [56] | 61 | 57% |
IPF patients who underwent assessment for lung transplantation at a single center in the UK [63] | 42 | 64% |
IPF patients at Inova Fairfax Hospital who were on the wait list for lung transplantation from 2000 to 2005 [64] | 74 | 18% |
IPF patients assessed for lung transplantation from January 1991 to June 1995 at the Toronto Lung Transplant Program [65] | 26 | 19% |
single center study of IPF patients at a single institution in Brazil registered on the waiting list from 2001 to June 2008 [66] | 33 | 24% |
single center study in France that included 46 IPF patients on the waiting list from 1988 to July 2001 [33] | 46 | 35% |
IPF patients referred for lung transplantation and lung-and-heart transplantation at a single center in Poland September 1999 and December 2004 [57] | 24 | 67% |
IPF patients enrolled at a lung transplant program in Italy (100 month time period) [58] | 53 | 44% |
Consecutive IPF patients assessed for lung transplantation between January 1997 and May 2006 at a single center in Israel (Pulmonary Institute of Rabin Medical Center) [67] | 85 | 48% |
IPF Patients enrolled from January – June 2004 at a single center in Israel (Pulmonary Institute of Rabin Medical Center) and followed from enrollment for a median of 2.4 years (range 2.0 to 3.1 years) [68]. | 51 | 14% |