Background
Methods
Data collection and study cohort
Statistics analysis
Results
Patient characteristics
Clinicopathological features |
n
| LC
M (P
25 ~ P
75) |
P
| LWR
M (P
25 ~ P
75) |
P
|
---|---|---|---|---|---|
Age (M (P
25 ~ P
75)) | 64(56 ~ 73) | -- | -- | ||
Gender | 0.751 | 0.019 | |||
Male | 209(55.29%) | 0.8(1.1 ~ 1.5) | 0.081(0.133 ~ 0.194) | ||
Female | 169(44.71%) | 0.8(1.1 ~ 1.5) | 0.095(0.145 ~ 0.222) | ||
Tumor stage | 0.586 | 0.058 | |||
III | 23(6.08%) | 0.9(1.2 ~ 1.5) | 0.127(0.190 ~ 0.214) | ||
IV | 355(93.92%) | 0.8(1.1 ~ 1.5) | 0.084(0.136 ~ 0.207) | ||
Primary tumor site | 0.110 | 0.308 | |||
Gastrointestinal tumors | 198(52.38%) | 0.7(1 ~ 1.4) | 0.081(0.131 ~ 0.190) | ||
Thoracic cancer | 86(22.75%) | 0.9(1.2 ~ 1.7) | 0.092(0.142 ~ 0.213) | ||
Urogenital neoplasms | 59(15.61%) | 0.8(1.1 ~ 1.6) | 0.088(0.147 ~ 0.235) | ||
Head and neck neoplasm | 16(4.23%) | 0.8(1.1 ~ 1.4) | 0.089(0.137 ~ 0.246) | ||
Other tumors | 19(5.03%) | 0.9(1.3 ~ 1.6) | 0.099(0.171 ~ 0.245) | ||
Family history | 0.935 | 0.999 | |||
No | 264(70.78%) | 0.8(1.1 ~ 1.5) | 0.083(0.141 ~ 0.203) | ||
Yes | 109(29.22%) | 0.8(1.1 ~ 1.5) | 0.091(0.127 ~ 0.222) | ||
Unknown | 5 | ||||
Smoking history | 0.478 | 0.005 | |||
No | 265(71.62%) | 0.8(1.1 ~ 1.5) | 0.092(0.145 ~ 0.214) | ||
Yes | 105(28.38%) | 0.8(1 ~ 1.5) | 0.075(0.118 ~ 0.185) | ||
Unknown | 8 | ||||
ECOG | 0.564 | <0.001 | |||
< 3 | 218(57.67%) | 0.8(1.1 ~ 1.5) | 0.094(0.146 ~ 0.231) | ||
> =3 | 160(42.33%) | 0.8(1.1 ~ 1.5) | 0.072(0.113 ~ 0.173) | ||
Concomitant disease | 0.440 | 0.968 | |||
No | 229(60.58%) | 0.8(1.1 ~ 1.5) | 0.085(0.138 ~ 0.214) | ||
Yes | 149(39.42%) | 0.8(1.1 ~ 1.6) | 0.088(0.139 ~ 0.198) | ||
Nutrient status | 0.012 | <0.001 | |||
Normal | 107(28.50%) | 0.8(1.2 ~ 1.6) | 0.108(0.169 ~ 0.233) | ||
Abnormal | 268(71.50%) | 0.8(1 ~ 1.45) | 0.079(0.129 ~ 0.196) | ||
Unknown | 3 |
Clinicopathological features |
n
| LC |
P value | LWR |
P value | ||
---|---|---|---|---|---|---|---|
Decreased | Increased | Decreased | Increased | ||||
Age (M (P
25 ~ P
75)) | 106 | 64(56-69) | 62(53-72) | 0.3708 | 64(56-72) | 62(53-70) | 0.2784 |
Gender | 0.0517 | 0.9756 | |||||
Male | 56(52.83%) | 23(43.40%) | 33(62.26%) | 36(52.94%) | 20(52.63%) | ||
Female | 50(47.17%) | 30(56.60%) | 20(37.74%) | 32(47.06%) | 18(47.37%) | ||
Tumor stage | 0.0382 | 0.0010 | |||||
III | 13(12.26%) | 3(5.66%) | 10(18.87%) | 3(4.41%) | 10(26.32%) | ||
IV | 93(87.74%) | 50(94.34%) | 43(81.13%) | 65(95.59%) | 28(73.68%) | ||
Primary tumor site | 0.6794 | 0.3937 | |||||
Gastrointestinal tumors | 60(56.60%) | 33(62.26%) | 27(50.94%) | 41(60.29%) | 19(50.00%) | ||
Thoracic ancer | 14(13.21%) | 6(11.32%) | 8(15.09%) | 9(13.24%) | 5(13.16%) | ||
Urogenital neoplasms | 23(21.70%) | 9(16.98%) | 14(26.42%) | 11(16.18%) | 12(31.58%) | ||
Head and neck neoplasm | 6(5.66%) | 3(5.66%) | 3(5.66%) | 5(7.35%) | 1(2.63%) | ||
Other tumors | 3(2.83%) | 2(3.77%) | 1(1.89%) | 2(2.94%) | 1(2.63%) | ||
Family history | 0.2943 | 0.4234 | |||||
No | 73(68.87%) | 34(64.15%) | 39(73.58%) | 45(66.18%) | 28(73.68%) | ||
Yes | 33(31.13%) | 19(35.85%) | 14(26.42%) | 23(33.82%) | 10(26.32%) | ||
Smoking history | 0.0905 | 0.8157 | |||||
No | 74(69.81%) | 41(77.36%) | 33(62.26%) | 48(70.59%) | 26(68.42%) | ||
Yes | 32(30.19%) | 12(22.64%) | 20(37.74%) | 20(29.41%) | 12(31.58%) | ||
ECOG | 0.1093 | 0.6462 | |||||
< 3 | 81(76.42%) | 37(69.81%) | 44(83.02%) | 51(75.00%) | 30(78.95%) | ||
> =3 | 25(23.58%) | 16(30.19%) | 9(16.98%) | 17(25.00%) | 8(21.05%) | ||
Concomitant disease | 0.5529 | 0.8093 | |||||
No | 63(59.43%) | 33(62.26%) | 30(56.60%) | 41(60.29%) | 22(57.89%) | ||
Yes | 43(40.57%) | 20(37.74%) | 23(43.40%) | 27(39.71%) | 16(42.11%) | ||
Nutrient status | 0.9360 | 0.4560 | |||||
Normal | 42(40.00%) | 21(40.38%) | 21(39.62%) | 25(37.31%) | 17(44.74%) | ||
Abnormal | 63(60.00%) | 31(59.62%) | 32(60.38%) | 42(62.69%) | 21(55.26%) | ||
Unknown | 1 | 1 | - | 1 | - |
Prognostic value of LWR
Prognostic factors | Median survival time (95% CI) | HRa(95% CI) |
P value |
---|---|---|---|
LC | 0.912 | ||
Quartile 1(<0.8 × 10*9/L) | 40.0 (32.1 ~ 48.0) | Reference | - |
Quartile 2(~1.1 × 10*9/L) | 45.0 (28.2 ~ 61.8) | 1.135(0.805 ~ 1.600) | 0.471 |
Quartile 3(~1.5 × 10*9/L) | 58.0 (31.8 ~ 84.2) | 1.081(0.768 ~ 1.520) | 0.655 |
Quartile 4(≥1.5 × 10*9/L) | 60.0 (40.5 ~ 79.5) | 1.082(0.777 ~ 1.506) | 0.642 |
LWR | |||
Quartile 1(<0.086) | 19.0(13.0 ~ 25.0) | Reference | - |
Quartile 2(~0.138) | 47.0(30.8 ~ 63.2) | 0.563(0.407 ~ 0.778) | 0.001 |
Quartile 3(~0.208) | 79.0(40.3 ~ 117.7) | 0.532(0.381 ~ 0.742) | <0.001 |
Quartile 4(≥0.208) | 101.0(55.1 ~ 146.9) | 0.466(0.328 ~ 0.661) | <0.001 |
Association of LC, LWR, and the changes in these values with OS
Clinicopathological features | LC Model | LWR Model | ||
---|---|---|---|---|
Adjusted HR(95% CI) |
P value | Adjusted HR (95% CI) |
P value | |
Gender (female vs. male) | 0.859(0.496 ~ 1.486) | 0.586 | 0.847(0.492 ~ 1.460) | 0.551 |
Age | 1.006(0.985 ~ 1.028) | 0.565 | 0.999(0.979 ~ 1.020) | 0.921 |
Primary tumor site | 0.787(0.618 ~ 1.003) | 0.053 | 0.751(0.590 ~ 0.955) | 0.019 |
Tumor stage (IV vs. III) | 2.813(1.076 ~ 7.356) | 0.035 | 1.971(0.738 ~ 5.263) | 0.176 |
Family history (Yes vs. No) | 1.405(0.846 ~ 2.333) | 0.189 | 1.424 (0.862 ~ 2.351) | 0.167 |
Smoke history (Yes vs. No) | 0.897(0.491 ~ 1.639) | 0.724 | 0.716(0.390 ~ 1.314) | 0.280 |
Nutrient (Abnormal vs. Normal) | 0.987(0.591 ~ 1.649) | 0.961 | 0.983(0.597 ~ 1.617) | 0.945 |
ECOG | 1.614(1.140 ~ 2.283) | 0.007 | 1.850(1.291 ~ 2.650) | 0.001 |
Concomitant disease (Yes vs. No) | 1.165(0.714 ~ 1.899) | 0.542 | 1.278(0.785 ~ 2.082) | 0.324 |
LC (Increased vs. Decreased) | 0.673(0.419 ~ 1.081) | 0.101 | -- | -- |
LWR(Increased vs. Decreased) | -- | -- | 0.396(0.243 ~ 0.668) | 0.001 |