Skip to main content
Erschienen in: Hernia 1/2017

03.12.2016 | Review

Male infertility following inguinal hernia repair: a systematic review and pooled analysis

verfasst von: A. Kordzadeh, M. O. Liu, N. V. Jayanthi

Erschienen in: Hernia | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

Introduction

The aim of this systematic review is to establish the clinical impact of open (mesh and/or without mesh) and laparoscopic hernia repair (transabdominal pre-peritoneal (TAP) and/or totally extra-peritoneal (TEP)) on male fertility. The incidence of male infertility following various types of inguinal hernia repair is currently unknown. The lack of high-quality evidence has led to various speculations, suggestions and reliance on anecdotal experience in the clinical practice.

Methods

An electronic search of the literature in Medline, Scopus, Embase and Cochrane library from 1966 to October 2015 according to PRISMA checklist was conducted. Quality assessment of articles was conducted using the Oxford Critical Appraisal Skills Programme (CASP) and their recommendation for practice was examined through National Institute for Health and Care Excellence (NICE). This resulted in ten studies (n = 10), comprising 35,740 patients.

Results

Sperm motility could be affected following any type and/or technique of inguinal hernia repair but this is limited to the immediate postoperative period (≤48 h). Obstructive azoospermia was noted in 0.03% of open and 2.5% of bilateral laparoscopic (TAP) hernia repair with mesh. Male infertility was detected in 0.8% of the open hernia repair (mesh) with no correlation to the type of mesh (lightweight vs. heavyweight).

Conclusion

Inguinal hernia repair without mesh has no impact on male fertility and obstructive azoospermia. However, the use of mesh in bilateral open and/or laparoscopic repair may require the inclusion of male infertility as the part of informed consent in individuals that have not completed their family or currently under investigations.
Literatur
2.
3.
Zurück zum Zitat The International Committee for Monitoring Assisted Reproductive Technology (ICMART) (2009) The World Health Organization (WHO) Revised Glossary on ART Terminology The International Committee for Monitoring Assisted Reproductive Technology (ICMART) (2009) The World Health Organization (WHO) Revised Glossary on ART Terminology
4.
Zurück zum Zitat Moher D, Liberati A, Tetzlaff J et al (2009) PRISMA group preferred reporting items for systematic reviews and meta analysis: the PRISMA statement. J clin Epidemol 62(10):1006–1012CrossRef Moher D, Liberati A, Tetzlaff J et al (2009) PRISMA group preferred reporting items for systematic reviews and meta analysis: the PRISMA statement. J clin Epidemol 62(10):1006–1012CrossRef
7.
Zurück zum Zitat Schafer M (2011) Bilateral endoscopic total extraperitoneal (TEP) inguinal hernia repair does not induce obstructive azoospermia: data of a retrospective and prospective trial. World J Surg 35:1649–1650CrossRefPubMed Schafer M (2011) Bilateral endoscopic total extraperitoneal (TEP) inguinal hernia repair does not induce obstructive azoospermia: data of a retrospective and prospective trial. World J Surg 35:1649–1650CrossRefPubMed
8.
Zurück zum Zitat Brendsen FH, Bjursten LM, Simanaitis M et al (2004) Does mesh implantation affect the spermatic cord structure after inguinal hernia surgery? Eur Surg Res 36:318–322CrossRef Brendsen FH, Bjursten LM, Simanaitis M et al (2004) Does mesh implantation affect the spermatic cord structure after inguinal hernia surgery? Eur Surg Res 36:318–322CrossRef
9.
Zurück zum Zitat Uzzo RG, Lemack GE, Morrissey KP et al (1999) The effect of mesh bioprosthesis on the spermatic cord structures: a preliminary report in canine model. J Urol 161:1344–1349CrossRefPubMed Uzzo RG, Lemack GE, Morrissey KP et al (1999) The effect of mesh bioprosthesis on the spermatic cord structures: a preliminary report in canine model. J Urol 161:1344–1349CrossRefPubMed
10.
Zurück zum Zitat Shah NR, Mikami DJ, Cook C et al. (2011) A comparison of outcomes between open and laparoscopic surgical repair of recurrent inguinal hernias. Surg Endosc 25(7):2330–2337CrossRefPubMed Shah NR, Mikami DJ, Cook C et al. (2011) A comparison of outcomes between open and laparoscopic surgical repair of recurrent inguinal hernias. Surg Endosc 25(7):2330–2337CrossRefPubMed
11.
Zurück zum Zitat Perko Z, Rakic M, Pogorelic Z et al (2011) Laparoscopic trans abdominal preperitoneal approach for inguinal hernia repair: a five year experience at a single center. Surg Today 41:216–221CrossRefPubMed Perko Z, Rakic M, Pogorelic Z et al (2011) Laparoscopic trans abdominal preperitoneal approach for inguinal hernia repair: a five year experience at a single center. Surg Today 41:216–221CrossRefPubMed
12.
Zurück zum Zitat Stula I, Druzijanic N, Srsen D, Capkun V, Perko Z, Sapunar A et al (2012) Influence of inguinal hernia mesh repair on testicular flow and sperm autoimmunity. Hernia 16(4):417–424CrossRefPubMed Stula I, Druzijanic N, Srsen D, Capkun V, Perko Z, Sapunar A et al (2012) Influence of inguinal hernia mesh repair on testicular flow and sperm autoimmunity. Hernia 16(4):417–424CrossRefPubMed
13.
Zurück zum Zitat Yavetz H, Harash B, Yogev L, Homonnai ZT, Paz G (1991) Fertility of men following inguinal hernia repair. Andrologia 23(6):443–446 Yavetz H, Harash B, Yogev L, Homonnai ZT, Paz G (1991) Fertility of men following inguinal hernia repair. Andrologia 23(6):443–446
14.
Zurück zum Zitat Aydede H, Erhan Y, Sakarya A, Kara E, Ilkgul O, Can M (2003) Effect of mesh and its localisation on testicular flow and spermatogenesis in patients with groin hernia. Acta Chir Belg 103(6):607–610 Aydede H, Erhan Y, Sakarya A, Kara E, Ilkgul O, Can M (2003) Effect of mesh and its localisation on testicular flow and spermatogenesis in patients with groin hernia. Acta Chir Belg 103(6):607–610
15.
Zurück zum Zitat Peeters E, Spiessens C, Oyen R, De Wever L, Vandeschueren D, Penninckx F et al (2014) Sperm motility after laparoscopic inguinal hernia with lightweight meshes: 3 year follow up of a randomised clinical trial. Hernia 18:361–367CrossRefPubMed Peeters E, Spiessens C, Oyen R, De Wever L, Vandeschueren D, Penninckx F et al (2014) Sperm motility after laparoscopic inguinal hernia with lightweight meshes: 3 year follow up of a randomised clinical trial. Hernia 18:361–367CrossRefPubMed
16.
Zurück zum Zitat Shin D, Lipshultz LI, Goldstein M, Barme GA, Fuchs EF, Nagler HM et al (2005) Herniorrhaphy with polypropylene mesh causing inguinal vasal obstruction: a preventable cause of obstructive azoospermia. Ann Surg 241(4):553–558CrossRefPubMedPubMedCentral Shin D, Lipshultz LI, Goldstein M, Barme GA, Fuchs EF, Nagler HM et al (2005) Herniorrhaphy with polypropylene mesh causing inguinal vasal obstruction: a preventable cause of obstructive azoospermia. Ann Surg 241(4):553–558CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Kiladze M, Gvenetadze T, Giorgobiani G (2009) Modified Lichtenshtein hernioplasty prevents male infertility. Ann Ital Chir 80(4):305–309 Kiladze M, Gvenetadze T, Giorgobiani G (2009) Modified Lichtenshtein hernioplasty prevents male infertility. Ann Ital Chir 80(4):305–309
18.
Zurück zum Zitat Skawran S, Weyhe D, Schmitz B, Belyaev O, Bauer KH (2011) Bilateral endoscopic total extraperitoneal (TEP) inguinal hernia repair does not induce obstructive azoospermia: data of a retrospective and prospective trial. World J Surg 35(7):1643–1648CrossRefPubMed Skawran S, Weyhe D, Schmitz B, Belyaev O, Bauer KH (2011) Bilateral endoscopic total extraperitoneal (TEP) inguinal hernia repair does not induce obstructive azoospermia: data of a retrospective and prospective trial. World J Surg 35(7):1643–1648CrossRefPubMed
19.
Zurück zum Zitat Hallen M, Sandblom G, Nordin P, Gunnarsson U, Kvist U, Westerdahl J (2011) Male infertility after mesh hernia repair: a prospective study. Surgery 149(2):179–184CrossRefPubMed Hallen M, Sandblom G, Nordin P, Gunnarsson U, Kvist U, Westerdahl J (2011) Male infertility after mesh hernia repair: a prospective study. Surgery 149(2):179–184CrossRefPubMed
20.
Zurück zum Zitat Hallen M, Westerdahl J, Nordin P, Gunnarsson U, Sandblom G (2012) Mesh hernia repair and male infertility: a retrospective register study. Surgery 151(1):94–98CrossRefPubMed Hallen M, Westerdahl J, Nordin P, Gunnarsson U, Sandblom G (2012) Mesh hernia repair and male infertility: a retrospective register study. Surgery 151(1):94–98CrossRefPubMed
21.
Zurück zum Zitat Stula I, Druzijanic N, Sapunar A, Perko Z, Bosnjak N, Kraljevic D (2014) Antisperm antibodies and testicular blood flow after inguinal hernia mesh repair. Surg Endosc 28(12):3413–3420CrossRefPubMed Stula I, Druzijanic N, Sapunar A, Perko Z, Bosnjak N, Kraljevic D (2014) Antisperm antibodies and testicular blood flow after inguinal hernia mesh repair. Surg Endosc 28(12):3413–3420CrossRefPubMed
Metadaten
Titel
Male infertility following inguinal hernia repair: a systematic review and pooled analysis
verfasst von
A. Kordzadeh
M. O. Liu
N. V. Jayanthi
Publikationsdatum
03.12.2016
Verlag
Springer Paris
Erschienen in
Hernia / Ausgabe 1/2017
Print ISSN: 1265-4906
Elektronische ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-016-1560-0

Weitere Artikel der Ausgabe 1/2017

Hernia 1/2017 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.