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28.09.2023 | Pancreatic Tumors

Malignant Solid Pseudopapillary Neoplasm of the Pancreas: An Orthogonal Analysis

verfasst von: Andrew M. Fleming, MD, Leah E. Hendrick, MD, MS, Danny Yakoub, MD, PhD, Hafeez Abdelhafeez, MD, Jeremiah L. Deneve, DO, Max R. Langham Jr., MD, Evan S. Glazer, MD, PhD, Andrew M. Davidoff, MD, Nipun B. Merchant, MD, Paxton V. Dickson, MD, Andrew J. Murphy, MD

Erschienen in: Annals of Surgical Oncology | Ausgabe 1/2024

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Abstract

Background

Pancreatic solid pseudopapillary neoplasms (SPN) are generally indolent; however, some patients present with “malignant” SPN. An orthogonal analysis of multiple datasets was performed to investigate the utility of complete surgical resection (CSR) for malignant SPN.

Methods

A systematic review was performed for cases of malignant SPN, defined as T4, N1, and/or M1. Malignant SPN was analyzed within the National Cancer Database (NCDB) and compared with T1-3N0M0 SPN. Predictors of malignant SPN were assessed, and treatments were analyzed by using survival analysis.

Results

The systematic review yielded 164 cases of malignant SPN. Of 31 children, only one died due to malignant SPN. Among adults, CSR was associated with improved disease-specific survival (DSS) (P = 0.0002). Chemotherapy did not improve malignant SPN DSS, whether resected (P = 0.8485) or not (P = 0.2219). Of 692 adults with SPN within the NCDB, 93 (13.4%) had malignant SPN. Pancreatic head location (odds ratio [OR] 2.174; 95% confidence interval [CI] 1.136–4.166; P = 0.0186) and tumor size (OR 1.154; 95% CI 1.079–1.235; P < 0.0001) associated with the malignant phenotype. Malignant SPN predicted decreased overall survival (OS) compared with T1-3N0M0 disease (P < 0.0001). Resected malignant SPN demonstrated improved OS (P < 0.0001), including resected stage IV malignant SPN (P = 0.0003). Chemotherapy did not improve OS for malignant SPN, whether resected (P = 0.8633) or not (P = 0.5734). Within a multivariable model, resection was associated with decreased hazard of death (hazard ratio 0.090; 95% CI 0.030–0.261; P < 0.0001).

Conclusions

Approximately 13% of patients with SPN present with a malignant phenotype. Pediatric cases may be less aggressive. Resection may improve survival for malignant SPN, which does not appear chemosensitive.

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Martin RC, Klimstra DS, Brennan MF, et al. Solid-pseudopapillary tumor of the pancreas: A surgical enigma? Ann Surg Oncol. 2002;9(1):35–40.PubMedCrossRef

Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005;200(6):965–72.PubMedCrossRef

Picado O, Ferrantella A, Zabalo C, et al. Treatment patterns and outcomes for pancreatic tumors in children: an analysis of the National Cancer Database. Pediatr Surg Int. 2020;36(3):357–63.PubMedCrossRef

Vasudevan SA, Ha TN, Zhu H, et al. Pancreaticoduodenectomy for the treatment of pancreatic neoplasms in children: A Pediatric Surgical Oncology Research Collaborative study. Pediatr Blood Cancer. 2020;67(9):e28425.PubMedPubMedCentralCrossRef

Frantz VK. Tumors of the pancreas. Armed Forces Institute of Pathology; 1959.

Klöppel G, Solcia E, Longnecker DS, et al. Histological typing of tumours of the exocrine pancreas / G. Klöppel ... [et al.] in collaboration with pathologists in 7 countries, 2nd edn. Berlin: Springer-Verlag; 1996.

Reddy S, Cameron JL, Scudiere J, et al. Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): A large single-institutional series. J Am Coll Surg. 2009;208(5):950–7 (discussion 957-9).

Lee SE, Jang JY, Hwang DW, et al. Clinical features and outcome of solid pseudopapillary neoplasm: differences between adults and children. Arch Surg. 2008;143(12):1218–21.PubMedCrossRef

Hanada K, Kurihara K, Itoi T, et al. Clinical and pathological features of solid pseudopapillary neoplasms of the pancreas: a nationwide multicenter study in Japan. Pancreas. 2018;47(8):1019–26.PubMedCrossRef

10.

Tanoue K, Mataki Y, Kurahara H, et al. Multidisciplinary treatment of advanced or recurrent solid pseudopapillary neoplasm of the pancreas: Three case reports. Surg Case Rep. 2022;8(1):7.PubMedPubMedCentralCrossRef

11.

Raman SP, Kawamoto S, Law JK, et al. Institutional experience with solid pseudopapillary neoplasms: focus on computed tomography, magnetic resonance imaging, conventional ultrasound, endoscopic ultrasound, and predictors of aggressive histology. J Comput Assist Tomogr. 2013;37(5):824–33.PubMedPubMedCentralCrossRef

12.

Estrella JS, Li L, Rashid A, et al. Solid pseudopapillary neoplasm of the pancreas: clinicopathologic and survival analyses of 64 cases from a single institution. Am J Surg Pathol. 2014;38(2):147–57.PubMedCrossRef

13.

Kim CW, Han DJ, Kim J, et al. Solid pseudopapillary tumor of the pancreas: can malignancy be predicted? Surgery. 2011;149(5):625–34.PubMedCrossRef

14.

Romics L Jr, Oláh A, Belágyi T, et al. Solid pseudopapillary neoplasm of the pancreas–proposed algorithms for diagnosis and surgical treatment. Langenbecks Arch Surg. 2010;395(6):747–55.PubMedCrossRef

15.

Maffuz A, Bustamante Fde T, Silva JA, et al. Preoperative gemcitabine for unresectable, solid pseudopapillary tumour of the pancreas. Lancet Oncol. 2005;6(3):185–6.PubMedCrossRef

16.

Allen M. The SAGE Encyclopedia of Communication Research Methods. Thousand Oaks, California: SAGE Publications, Inc; 2017.CrossRef

17.

Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.PubMedPubMedCentralCrossRef

18.

JBI. JBI Critical Appraisal Checklist for Case Reports: JBI2022.

19.

Corrente RF. Cystadenocarcinoma of the pancreas. Am J Surg. 1980;139(2):265–7.PubMedCrossRef

20.

Dales RL, Garcia JC, Davies RS. Papillary-cystic carcinoma of the pancreas. J Surg Oncol. 1983;22(2):115–7.PubMedCrossRef

21.

Sanfey H, Mendelsohn G, Cameron JL. Solid and papillary neoplasm of the pancreas. A potentially curable surgical lesion. Ann Surg. 1983;197(3):272–5.PubMedPubMedCentralCrossRef

22.

Morrison DM, Jewell LD, McCaughey WT, et al. Papillary cystic tumor of the pancreas. Arch Pathol Lab Med. 1984;108(9):723–7.PubMed

23.

Fried P, Cooper J, Balthazar E, et al. A role for radiotherapy in the treatment of solid and papillary neoplasms of the pancreas. Cancer. 1985;56(12):2783–5.PubMedCrossRef

24.

Warren RB. Papillary cystic tumor of the pancreas. Arch Pathol Lab Med. 1985;109(8):706–7.PubMed

25.

Kaufman SL, Reddick RL, Stiegel M, et al. Papillary cystic neoplasm of the pancreas: a curable pancreatic tumor. World J Surg. 1986;10(5):851–9.PubMedCrossRef

26.

Rustin RB, Broughan TA, Hermann RE, et al. Papillary cystic epithelial neoplasms of the pancreas: A clinical study of four cases. Arch Surg. 1986;121(9):1073–6.PubMedCrossRef

27.

Lieber MR, Lack EE, Roberts JR Jr, et al. Solid and papillary epithelial neoplasm of the pancreas. An ultrastructural and immunocytochemical study of six cases. Am J Surg Pathol. 1987;11(2):85–93.PubMedCrossRef

28.

Stachura J, Popiela T, Pietroń M, et al. Cytology of solid and papillary epithelial neoplasms of the pancreas: a case report. Diagn Cytopathol. 1988;4(4):339–41.PubMedCrossRef

29.

Todani T, Shimada K, Watanabe Y, et al. Frantz’s tumor: A papillary and cystic tumor of the pancreas in girls. J Pediatric Surg. 1988;23(2):116–21.CrossRef

30.

Heitz PU, Stolte M, Kloeppel G. Large pancreatic tumor in a young woman. Ultrastruct Pathol. 1989;13(5–6):589–92.PubMedCrossRef

31.

Hernandez-Maldonado JJ, Rodriguez-Bigas MA, Gonzalez de Pesante A, et al. Papillary cystic neoplasm of the pancreas. A report of a case presenting with carcinomatosis. Am Surg. 1989;55(9):552-9.

32.

Yamaguchi K, Miyagahara T, Tsuneyoshi M, et al. Papillary cystic tumor of the pancreas: an immunohistochemical and ultrastructural study of 14 patients. Jpn J Clin Oncol. 1989;19(2):102–11.PubMed

33.

Cappellari JO, Geisinger KR, Albertson DA, et al. Malignant papillary cystic tumor of the pancreas. Cancer. 1990;66(1):193–8.PubMedCrossRef

34.

Matsunou H, Konishi F, Yamamichi N, et al. Solid, infiltrating variety of papillary cystic neoplasm of the pancreas. Cancer. 1990;65(12):2747–57.PubMedCrossRef

35.

Zinner MJ, Shurbaji MS, Cameron JL. Solid and papillary epithelial neoplasms of the pancreas. Surgery. 1990;108(3):475–80.PubMed

36.

Sclafani LM, Reuter VE, Coit DG, et al. The malignant nature of papillary and cystic neoplasm of the pancreas. Cancer. 1991;68(1):153–8.PubMedCrossRef

37.

Stömmer P, Kraus J, Stolte M, et al. Solid and cystic pancreatic tumors. Clinical, histochemical, and electron microscopic features in ten cases. Cancer. 1991;67(6):1635-41.

38.

Tsunoda T, Eto T, Tsurifune T, et al. Solid and cystic tumor of the pancreas in an adult male. Acta Pathol Jpn. 1991;41(10):763–70.PubMed

39.

Jaksic T, Yaman M, Thorner P, et al. A 20-year review of pediatric pancreatic tumors. J Pediatric Surg. 1992;27(10):1315–7.CrossRef

40.

Kingsnorth AN, Galloway SW, Lewis-Jones H, et al. Papillary cystic neoplasm of the pancreas: presentation and natural history in two cases. Gut. 1992;33(3):421–3.PubMedPubMedCentralCrossRef

41.

Nishihara K, Nagoshi M, Tsuneyoshi M, et al. Papillary cystic tumors of the pancreas. Assessment of their malignant potential. Cancer. 1993;71(1):82–92.PubMedCrossRef

42.

González-Cámpora R, Rios Martin JJ, Villar Rodriguez JL, et al. Papillary cystic neoplasm of the pancreas with liver metastasis coexisting with thyroid papillary carcinoma. Arch Pathol Lab Med. 1995;119(3):268–73.PubMed

43.

Mao C, Guvendi M, Domenico DR, et al. Papillary cystic and solid tumors of the pancreas: a pancreatic embryonic tumor? Studies of three cases and cumulative review of the world’s literature. Surgery. 1995;118(5):821–8.PubMedCrossRef

44.

Ky A, Shilyansky J, Gerstle J, et al. Experience with papillary and solid epithelial neoplasms of the pancreas in children. J Pediatric Surg. 1998;33(1):42–4.CrossRef

45.

Panieri E, Krige JE, Bornman PC, et al. Operative management of papillary cystic neoplasms of the pancreas. J Am Coll Surg. 1998;186(3):319–24.PubMedCrossRef

46.

Shimizu M, Matsumoto T, Hirokawa M, et al. Solid-pseudopapillary carcinoma of the pancreas. Pathol Int. 1999;49(3):231–4.PubMedCrossRef

47.

Saiura A, Umekita N, Matsui Y, et al. Successful surgical resection of solid cystic tumor of the pancreas with multiple liver metastases and a tumor thrombus in the portal vein. Hepatogastroenterology. 2000;47(33):887–9.PubMed

48.

Müller-Höcker J, Zietz CH, Sendelhofert A. Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas. Mod Pathol. 2001;14(2):47–53.PubMedCrossRef

49.

Rebhandl W, Felberbauer FX, Puig S, et al. Solid-pseudopapillary tumor of the pancreas (Frantz tumor) in children: report of four cases and review of the literature. J Surg Oncol. 2001;76(4):289–96.PubMedCrossRef

50.

Lee YR, Kim Y, Koh BH, et al. Solid and papillary epithelial neoplasm of the pancreas with peritoneal metastasis and its recurrence: a case report. Abdom Imaging. 2003;28(1):96–8.PubMedCrossRef

51.

Podevin J, Triau S, Mirallié E, et al. Solid-pseudopapillary tumor of the pancreas: a clinical study of five cases, and review of the literature. Ann Chir. 2003;128(8):543–8.PubMedCrossRef

52.

Usatoff V, Wittkop B, Devalia K, et al. Solid papillary-cystic carcinoma of the pancreas with portal vein tumour thrombus. ANZ J Surg. 2004;74(4):291–3.PubMedCrossRef

53.

Ahmad Z, Yaqoob N, Muzaffar S, et al. Solid and cystic epithelial neoplasm of pancreas with metastasis: report of a highly unusual case. J Pak Med Assoc. 2005;55(1):37–9.PubMed

54.

Alexandrescu DT, O’Boyle K, Feliz A, et al. Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management. Clin Oncol (R Coll Radiol). 2005;17(5):358–63.PubMedCrossRef

55.

Chen X, Zhou GW, Zhou HJ, et al. Diagnosis and treatment of solid-pseudopapillary tumors of the pancreas. Hepatobiliary Pancreat Dis Int. 2005;4(3):456–9.PubMed

56.

Hassan I, Celik I, Nies C, et al. Successful treatment of solid-pseudopapillary tumor of the pancreas with multiple liver metastases. Pancreatology. 2005;5(2–3):289–94.PubMedCrossRef

57.

Huang HL, Shih SC, Chang WH, et al. Solid-pseudopapillary tumor of the pancreas: clinical experience and literature review. World J Gastroenterol. 2005;11(9):1403–9.PubMedPubMedCentralCrossRef

58.

Sun CD, Lee WJ, Choi JS, et al. Solid-pseudopapillary tumours of the pancreas: 14 years experience. ANZ J Surg. 2005;75(8):684–9.PubMedCrossRef

59.

Takahashi Y, Fukusato T, Aita K, et al. Solid pseudopapillary tumor of the pancreas with metastases to the lung and liver. Pathol Int. 2005;55(12):792–6.PubMedCrossRef

60.

Tang LH, Aydin H, Brennan MF, et al. Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am J Surg Pathol. 2005;29(4):512–9.PubMedCrossRef

61.

Adamthwaite JA, Verbeke CS, Stringer MD, et al. Solid pseudopapillary tumour of the pancreas: Diverse presentation, outcome and histology. JOP. 2006;7(6):635–42.PubMed

62.

Arias de la Vega F, Gómez Dorronsoro ML, Jiménez FJ. Subcutaneous metastasis as the first manifestation of a solid-pseudopapillary tumor of the pancreas. Clin Transl Oncol. 2006;8(2):136-8.

63.

Cao D, Antonescu C, Wong G, et al. Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations. Mod Pathol. 2006;19(9):1157–63.PubMedCrossRef

64.

Frago R, Fabregat J, Jorba R, et al. Solid pseudopapillary tumors of the pancreas: diagnosis and curative treatment. Rev Esp Enferm Dig. 2006;98(11):809–16.PubMedCrossRef

65.

Gedaly R, Toledano A, Millan G, et al. Treatment of liver metastases from a solid pseudopapillary tumor of the pancreas. J Hepatobiliary Pancreat Surg. 2006;13(6):587–90.PubMedCrossRef

66.

Hao CY, Lu AP, Xing BC, et al. Solid pseudopapillary tumor of the pancreas: report of 8 cases in a single institution and review of the Chinese literature. Pancreatology. 2006;6(4):291–6.PubMedCrossRef

67.

Kang CM, Kim KS, Choi JS, et al. Solid pseudopapillary tumor of the pancreas suggesting malignant potential. Pancreas. 2006;32(3):276–80.PubMedCrossRef

68.

Okino HH, Kitaura Y, Onitsuka K, et al. An operative case of metastatic solid-pseudopapillary tumor in the liver after curative resection. Japanese J Gastroenterol Surg. 2006;39(3):340–6.CrossRef

69.

Tipton SG, Smyrk TC, Sarr MG, et al. Malignant potential of solid pseudopapillary neoplasm of the pancreas. Br J Surg. 2006;93(6):733–7.PubMedCrossRef

70.

Zauls JA, Dragun AE, Sharma AK. Intensity-modulated radiation therapy for unresectable solid pseudopapillary tumor of the pancreas. Am J Clin Oncol. 2006;29(6):639–40.PubMedCrossRef

71.

Goh BK, Tan YM, Cheow PC, et al. Solid pseudopapillary neoplasms of the pancreas: An updated experience. J Surg Oncol. 2007;95(8):640–4.PubMedCrossRef

72.

Hah JO, Park WK, Lee NH, et al. Preoperative chemotherapy and intraoperative radiofrequency ablation for unresectable solid pseudopapillary tumor of the pancreas. J Pediatr Hematol Oncol. 2007;29(12):851–3.PubMedCrossRef

73.

Nagri S, Abdu A, Anand S, et al. Liver metastasis four years after Whipple’s resection for solid-pseudopapillary tumor of the pancreas. JOP. 2007;8(2):223–7.PubMed

74.

Sumida W, Kaneko K, Tainaka T, et al. Liver transplantation for multiple liver metastases from solid pseudopapillary tumor of the pancreas. J Pediatric Surg. 2007;42(12):e27-31.CrossRef

75.

Kocman B, Jadrijević S, Skopljanac A, et al. Living donor liver transplantation for unresectable liver metastases from solid pseudo-papillary tumor of the pancreas: a case report. Transplant Proc. 2008;40(10):3787–90.PubMedCrossRef

76.

Shaikh S, Arya S, Ramadwar M, et al. Three cases of unusual solid pseudopapillary tumors. Can radiology and histology aid decision-making? JOP. 2008;9(2):150-9.

77.

Sperti C, Berselli M, Pasquali C, et al. Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: a case report and review of the literature. World J Gastroenterol. 2008;14(6):960–5.PubMedPubMedCentralCrossRef

78.

Li WH, Chan C, Cheung MT. A young woman with metastatic solid pseudopapillary tumour of the pancreas. ANZ J Surg. 2009;79(10):750–1.PubMedCrossRef

79.

Dovigo AG, Díaz MB, Gütierrez MG, et al. Liver transplantation as treatment in a massive metastasis from Gruber-Frantz pancreatic tumor: A case report. Transplant Proc. 2011;43(6):2272–3.PubMedCrossRef

80.

Gomez P, Yorke R, Ayala AG, et al. Solid-pseudopapillary neoplasm of pancreas with long delayed liver metastasis. Ann Diagn Pathol. 2012;16(5):380–4.PubMedCrossRef

81.

Honore C, Goere D, Dartigues P, et al. Peritoneal carcinomatosis from solid pseudopapillary neoplasm (Frantz’s tumour) of the pancreas treated with HIPEC. Anticancer Res. 2012;32(3):1069–73.PubMed

82.

Ji S, Xu J, Zhang B, et al. Management of a malignant case of solid pseudopapillary tumor of pancreas: a case report and literature review. Pancreas. 2012;41(8):1336–40.PubMedCrossRef

83.

Krug S, Bartsch DK, Schober M, et al. Successful selective internal radiotherapy (SIRT) in a patient with a malignant solid pseudopapillary pancreatic neoplasm (SPN). Pancreatology. 2012;12(5):423–7.PubMedCrossRef

84.

Li JX, Wu H, Huang JW, et al. Synchronous intraoperative radiofrequency ablation for multiple liver metastasis and resection of giant solid pseudopapillary tumors of the pancreas. Chin Med J (Engl). 2012;125(9):1661–3.PubMed

85.

Tajima Y, Kohara N, Maeda J, et al. Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas: report of a case. Surg Today. 2012;42(8):776–80.PubMedCrossRef

86.

Yoon HJ, Lim JH. Solid pseudopapillary tumor of the pancreas with hepatic metastasis: spontaneous regression over 10-year follow-up period. Korean J Radiol. 2012;13(5):648–51.PubMedPubMedCentralCrossRef

87.

Dixon M, Cannon J, Kagedan D, et al. Management of metastatic solid pseudopapillary cancer of the pancreas: a case report. World J Oncol. 2013;4(4–5):201–4.PubMedPubMedCentral

88.

Łągiewska B, Pacholczyk M, Lisik W, et al. Liver transplantation for nonresectable metastatic solid pseudopapillary pancreatic cancer. Ann Transplant. 2013;18:651–3.PubMedCrossRef

89.

Morikawa T, Onogawa T, Maeda S, et al. Solid pseudopapillary neoplasms of the pancreas: an 18-year experience at a single Japanese Institution. Surg Today. 2013;43(1):26–32.PubMedCrossRef

90.

Yagcı A, Yakan S, Coskun A, et al. Diagnosis and treatment of solid pseudopapillary tumor of the pancreas: experience of one single institution from Turkey. World J Surg Oncol. 2013;11:308.PubMedPubMedCentralCrossRef

91.

Hosokawa I, Shimizu H, Ohtsuka M, et al. Preoperative diagnosis and surgical management for solid pseudopapillary neoplasm of the pancreas. J Hepato-biliary-Pancreatic Sci. 2014;21(8):573–8.CrossRef

92.

Prasad TV, Madhusudhan KS, Srivastava DN, et al. Transarterial chemoembolization for liver metastases from solid pseudopapillary epithelial neoplasm of pancreas: a case report. World J Radiol. 2015;7(3):61–5.PubMedPubMedCentralCrossRef

93.

Violari EG, Brody LA, Covey AM, et al. Successful control of liver metastases from pancreatic solid-pseudopapillary neoplasm (SPN) using hepatic arterial embolization. Cardiovasc Intervent Radiol. 2015;38(2):479–83.PubMedCrossRef

94.

Choi HW, Park HJ, Hong SA, et al. Radiologic findings in extrapancreatic solid pseudopapillary tumor with aggressive behavior: a case report. J Korean Med Sci. 2017;32(12):2079–84.PubMedPubMedCentralCrossRef

95.

Escobar MA, Jr., McClellan JM, Thomas W. Solid pseudopapillary tumour (Frantz's tumour) of the pancreas in childhood: successful management of late liver metastases with sunitinib and chemoembolisation. BMJ Case Reports. 2017.

96.

Lee HS, Kim HK, Shin BK, et al. A rare case of recurrent metastatic solid pseudopapillary neoplasm of the pancreas. J Pathol Transl Med. 2017;51(1):87–91.PubMedCrossRef

97.

Yang F, Jin C, Fu D. Evolution of liver metastasis from solid pseudopapillary tumor of the pancreas. Surgery. 2017;161(6):1739–40.PubMedCrossRef

98.

Neill KG, Saller J, Al Diffalha S, et al. EGFR L861Q Mutation in a Metastatic Solid-pseudopapillary Neoplasm of the Pancreas. Cancer Genom Proteomics. 2018;15(3):201–5.

99.

Prakash PS, Chan DYS, Madhavan K. The stomach: a rare site for metastatic solid pseudopapillary neoplasm of the pancreas. J Gastrointest Surg. 2018;22(4):759–60.PubMedCrossRef

100.

Wójciak M, Gozdowska J, Pacholczyk M, et al. Liver transplantation for a metastatic pancreatic solid-pseudopapillary tumor (Frantz Tumor): a case report. Ann Transplant. 2018;23:520–3.PubMedPubMedCentralCrossRef

101.

Song TL, Chen H, Wang FR, et al. Combined treatment for solid pseudopapillary tumor of the pancreas with liver metastasis. Hepatobiliary Pancreat Dis Int. 2019;18(5):495–7.PubMedCrossRef

102.

Dyas AR, Johnson DT, Rubin E, et al. Yttrium-90 selective internal radiotherapy as bridge to curative hepatectomy for recurrent malignant solid pseudopapillary neoplasm of pancreas: case report and review of literature. J Surg Case Rep. 2020;2020(9):rjaa325.

103.

Santos D, Calhau A, Bacelar F, et al. Solid pseudopapillary neoplasm of pancreas with distant metastasis during pregnancy: A diagnostic and treatment challenge. BMJ Case Rep. 2020;13(12).

104.

Takaichi S, Iwagami Y, Kobayashi S, et al. Minimally invasive approach for pancreatic solid pseudopapillary neoplasm and initially undiagnosed slowly progressing liver tumor: a case report. Pancreas. 2020;49(8):e70–2.PubMedCrossRef

105.

Tomioka K, Ohike N, Aoki T, et al. Solid pseudopapillary neoplasm of the pancreas with high-grade malignant transformation involving p16-RB pathway alterations. Case Rep Surg. 2020;2020:5980382.PubMedPubMedCentral

106.

Ichimura K, Uesaka T, Kikuchi H, et al. Repeated resection for recurrent metastatic solid pseudopapillary neoplasm of the pancreas. Am J Case Rep. 2021;22:e934798.PubMedPubMedCentralCrossRef

107.

Wang X, Zhu D, Bao W, et al. Case report: Targeted therapy for metastatic solid pseudopapillary neoplasm of the pancreas with CTNNB1 and PTEN mutations. Front Oncol. 2021;11:729151.PubMedPubMedCentralCrossRef

108.

Park S, Park MG, Roh YH, et al. Solid pseudopapillary neoplasm of the pancreas with lymph node metastasis in a young male patient. Korean J Gastroenterol. 2022;79(2):77–82.PubMedCrossRef

109.

Ranaweera K, Nandasena M, de Silva U, et al. Solid pseudopapillary neoplasm of the pancreas with multiple liver metastases successfully managed with staged resection. SAGE Open Med Case Rep. 2022;10:2050313x221101995.

110.

Nissen T, Wynn R. The clinical case report: a review of its merits and limitations. BMC Res Notes. 2014;7:264.PubMedPubMedCentralCrossRef

111.

Hwang J, Kim DY, Kim SC, et al. Solid-pseudopapillary neoplasm of the pancreas in children: can we predict malignancy? J Pediatric Surg. 2014;49(12):1730–3.CrossRef

112.

Brecht IB, Schneider DT, Klöppel G, et al. Malignant pancreatic tumors in children and young adults: evaluation of 228 patients identified through the Surveillance, Epidemiology, and End Result (SEER) database. Klin Padiatr. 2011;223(6):341–5.PubMedCrossRef

113.

Kim MJ, Choi DW, Choi SH, et al. Surgical treatment of solid pseudopapillary neoplasms of the pancreas and risk factors for malignancy. Br J Surg. 2014;101(10):1266–71.PubMedCrossRef

114.

Butte JM, Brennan MF, Gönen M, et al. Solid pseudopapillary tumors of the pancreas. Clinical features, surgical outcomes, and long-term survival in 45 consecutive patients from a single center. J Gastrointest Surg. 2011;15(2):350-7.

115.

You L, Yang F, Fu DL. Prediction of malignancy and adverse outcome of solid pseudopapillary tumor of the pancreas. World J Gastrointest Oncol. 2018;10(7):184–93.PubMedPubMedCentralCrossRef

116.

Yin Q, Wang M, Wang C, et al. Differentiation between benign and malignant solid pseudopapillary tumor of the pancreas by MDCT. Eur J Radiol. 2012;81(11):3010–8.PubMedCrossRef

117.

Soloni P, Cecchetto G, Dall'igna P, et al. Management of unresectable solid papillary cystic tumor of the pancreas. A case report and literature review. J Pediatr Surg. 2010;45(5):e1-6.

118.

Yalçın B, Yağcı-Küpeli B, Ekinci S, et al. Solid pseudopapillary neoplasm of the pancreas in children: Hacettepe experience. ANZ J Surg. 2019;89(6):E236–40.PubMedCrossRef

119.

Botta L, Gatta G, Trama A, et al. Incidence and survival of rare cancers in the US and Europe. Cancer Med. 2020;9(15):5632–42.PubMedPubMedCentralCrossRef

120.

Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clin Res ed). 2021;372:n71.

Titel: Malignant Solid Pseudopapillary Neoplasm of the Pancreas: An Orthogonal Analysis
verfasst von: Andrew M. Fleming, MD
Leah E. Hendrick, MD, MS
Danny Yakoub, MD, PhD
Hafeez Abdelhafeez, MD
Jeremiah L. Deneve, DO
Max R. Langham Jr., MD
Evan S. Glazer, MD, PhD
Andrew M. Davidoff, MD
Nipun B. Merchant, MD
Paxton V. Dickson, MD
Andrew J. Murphy, MD
Publikationsdatum: 28.09.2023
Verlag: Springer International Publishing
Erschienen in: Annals of Surgical Oncology / Ausgabe 1/2024
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-023-14343-0

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10.05.2024 Koronare Herzerkrankung Nachrichten

Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Deutlich weniger Infektionen: Wundprotektoren schützen!

08.05.2024 Postoperative Wundinfektion Nachrichten

Der Einsatz von Wundprotektoren bei offenen Eingriffen am unteren Gastrointestinaltrakt schützt vor Infektionen im Op.-Gebiet – und dient darüber hinaus der besseren Sicht. Das bestätigt mit großer Robustheit eine randomisierte Studie im Fachblatt JAMA Surgery.

Chirurginnen und Chirurgen sind stark suizidgefährdet

07.05.2024 Suizid Nachrichten

Der belastende Arbeitsalltag wirkt sich negativ auf die psychische Gesundheit der Angehörigen ärztlicher Berufsgruppen aus. Chirurginnen und Chirurgen bilden da keine Ausnahme, im Gegenteil.

Update Chirurgie

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Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare

CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare

CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske

Dr. med. Benjamin Meyknecht

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare

CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Malignant Solid Pseudopapillary Neoplasm of the Pancreas: An Orthogonal Analysis

Abstract

Background

Methods

Results

Conclusions

Neu im Fachgebiet Chirurgie

Vorsicht, erhöhte Blutungsgefahr nach PCI!

Darf man die Behandlung eines Neonazis ablehnen?

Deutlich weniger Infektionen: Wundprotektoren schützen!

Chirurginnen und Chirurgen sind stark suizidgefährdet

Update Chirurgie

Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

S2e-Leitlinie „Distale Radiusfraktur“

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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Weitere Artikel der Ausgabe 1/2024

Reply to “Staging of the Axilla After Neoadjuvant Chemotherapy: Which Technique is Better? The Endless Debate

Is Systemic Chemotherapy Useful in Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases? A Propensity-Score Analysis

Relatlimab, an Immune Checkpoint Inhibitor that Blocks LAG-3, the Latest Drug to be Added to the Arsenal of Systemic Therapies for Melanoma: What Does a Surgical Oncologist Need to Know?

ASO Visual Abstract: Factors Associated with 1-Year Mortality of Elderly Patients (Age 80 Years and Older) with Cancer Undergoing Major Abdominal Surgery: A Retrospective Cohort Study

Best Practices for Handling Missing Data

Perceptions of Readiness for Practice After Complex General Surgical Oncology Fellowship: A Survey Study

Update Chirurgie