Erschienen in:
23.11.2020 | Correspondence
Malignant transformation of a polymorphous low grade neuroepithelial tumor of the young (PLNTY)
verfasst von:
Tejus A. Bale, Sameer F. Sait, Jamal Benhamida, Ryan Ptashkin, Sofia Haque, Liliana Villafania, Martin Sill, Justyna Sadowska, Razia B. Akhtar, Benjamin Liechty, Rupa Juthani, Marc Ladanyi, Mary Fowkes, Matthias A. Karajannis, Marc K. Rosenblum
Erschienen in:
Acta Neuropathologica
|
Ausgabe 1/2021
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Excerpt
PLNTY comprise an indolent group of tumors in children and young adults harboring MAPK pathway alterations [
2,
5,
6] including
FGFR3-TACC3 fusions, which also characterize a subset of glioblastomas [
1]. To date, there have been no reports of aggressive behavior and malignant transformation in tumors meeting diagnostic criteria for PLNTY. Here, we present a pediatric patient diagnosed with PLNTY with
FGFR3-TACC3 fusion, who experienced recurrent glioblastoma-like disease within < 18 months. …