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Targeted Oncology

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01.03.2011 | Review

Mammalian target of rapamycin as a target in hematological malignancies

verfasst von: Kevin R. Kelly, Julie H. Rowe, Swaminathan Padmanabhan, Steffan T. Nawrocki, Jennifer S. Carew

Erschienen in: Targeted Oncology | Ausgabe 1/2011

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Abstract

The mammalian target of rapamycin (mTOR) regulates protein synthesis in addition to cell growth and cell proliferation. Elucidation of the roles of the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR pathway in the regulation of the pathogenesis of hematological neoplasms has led to the development and clinical evaluation of agents targeting this pathway for the treatment of leukemia and lymphomas. Clinical trials conducted to date have shown modest responses to mTOR inhibition in patients with various hematological malignancies. Novel agents that simultaneously target mTOR complex 2 (mTORC2) or AKT in addition to mTOR complex 1 (mTORC1) may offer an opportunity to improve therapeutic efficacy.

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Titel: Mammalian target of rapamycin as a target in hematological malignancies
verfasst von: Kevin R. Kelly
Julie H. Rowe
Swaminathan Padmanabhan
Steffan T. Nawrocki
Jennifer S. Carew
Publikationsdatum: 01.03.2011
Verlag: Springer-Verlag
Erschienen in: Targeted Oncology / Ausgabe 1/2011
Print ISSN: 1776-2596
Elektronische ISSN: 1776-260X
DOI: https://doi.org/10.1007/s11523-011-0175-8

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Mammalian target of rapamycin as a target in hematological malignancies

Abstract

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Die Highlights vom Kongress des American College of Cardiology 2024

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Abstract

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