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03.02.2020 | Narrative Review

Management of HIV-infected patients in the intensive care unit

verfasst von: François Barbier, Mervin Mer, Piotr Szychowiak, Robert F. Miller, Éric Mariotte, Lionel Galicier, Lila Bouadma, Pierre Tattevin, Élie Azoulay

Erschienen in: Intensive Care Medicine | Ausgabe 2/2020

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Abstract

The widespread use of combination antiretroviral therapies (cART) has converted the prognosis of HIV infection from a rapidly progressive and ultimately fatal disease to a chronic condition with limited impact on life expectancy. Yet, HIV-infected patients remain at high risk for critical illness due to the occurrence of severe opportunistic infections in those with advanced immunosuppression (i.e., inaugural admissions or limited access to cART), a pronounced susceptibility to bacterial sepsis and tuberculosis at every stage of HIV infection, and a rising prevalence of underlying comorbidities such as chronic obstructive pulmonary diseases, atherosclerosis or non-AIDS-defining neoplasms in cART-treated patients aging with controlled viral replication. Several patterns of intensive care have markedly evolved in this patient population over the late cART era, including a steady decline in AIDS-related admissions, an opposite trend in admissions for exacerbated comorbidities, the emergence of additional drivers of immunosuppression (e.g., anti-neoplastic chemotherapy or solid organ transplantation), the management of cART in the acute phase of critical illness, and a dramatic progress in short-term survival that mainly results from general advances in intensive care practices. Besides, there is a lack of data regarding other features of ICU and post-ICU care in these patients, especially on the impact of sociological factors on clinical presentation and prognosis, the optimal timing of cART introduction in AIDS-related admissions, determinants of end-of-life decisions, long-term survival, and functional outcomes. In this narrative review, we sought to depict the current evidence regarding the management of HIV-infected patients admitted to the intensive care unit.

World Health Organization (2019) Global HIV and AIDS statistics. http://www.unaids.org. Accessed 1 Nov 2019

Akgun KM, Miller RF (2016) Critical care in human immunodeficiency virus-infected patients. Semin Respir Crit Care Med 37(2):303–317PubMed

Azoulay E, de Castro N, Barbier F (2019) Critically ill patients with HIV: 40 years later. Chest. https://doi.org/10.1016/j.chest.2019.08.002 CrossRefPubMed

Akgun KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP et al (2013) Risk factors for hospitalization and medical intensive care unit (MICU) admission among HIV-infected Veterans. J Acquir Immune Defic Syndr 62(1):52–59PubMedPubMedCentral

Coquet I, Pavie J, Palmer P, Barbier F, Legriel S, Mayaux J et al (2010) Survival trends in critically ill HIV-infected patients in the highly active antiretroviral therapy era. Crit Care 14(3):R107PubMedPubMedCentral

Japiassu AM, Amancio RT, Mesquita EC, Medeiros DM, Bernal HB, Nunes EP et al (2010) Sepsis is a major determinant of outcome in critically ill HIV/AIDS patients. Crit Care 14(4):R152PubMedPubMedCentral

Chiang HH, Hung CC, Lee CM, Chen HY, Chen MY, Sheng WH et al (2011) Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: etiology and prognostic factors. Crit Care 15(4):R202PubMedPubMedCentral

Xiao J, Zhang W, Huang Y, Tian Y, Su W, Li Y et al (2015) Etiology and outcomes for patients infected with HIV in intensive care units in a tertiary care hospital in China. J Med Virol 87(3):366–374PubMed

Kwizera A, Nabukenya M, Peter A, Semogerere L, Ayebale E, Katabira C et al (2016) Clinical characteristics and short-term outcomes of HIV patients admitted to an african intensive care unit. Crit Care Res Pract 2016:2610873PubMedPubMedCentral

10.

Deeks SG, Lewin SR, Havlir DV (2013) The end of AIDS: HIV infection as a chronic disease. Lancet 382(9903):1525–1533PubMedPubMedCentral

11.

World Health Organization (2016) Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach, 2nd edn. https://www.who.int. Accessed 1 Nov 2019

12.

Althoff KN, McGinnis KA, Wyatt CM, Freiberg MS, Gilbert C, Oursler KK et al (2014) Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected vs uninfected adults. Clin Infect Dis 60:627–638PubMedPubMedCentral

13.

Freiberg MS, Chang CC, Kuller LH, Skanderson M, Lowy E, Kraemer KL et al (2013) HIV infection and the risk of acute myocardial infarction. JAMA Intern Med 2013:1–9

14.

Lanoy E, Spano JP, Bonnet F, Guiguet M, Boue F, Cadranel J et al (2011) The spectrum of malignancies in HIV-infected patients in 2006 in France: the ONCOVIH study. Int J Cancer 129(2):467–475PubMed

15.

Crothers K, Huang L, Goulet JL, Goetz MB, Brown ST, Rodriguez-Barradas MC et al (2011) HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era. Am J Respir Crit Care Med 183(3):388–395PubMedPubMedCentral

16.

Sigel K, Wisnivesky J, Gordon K, Dubrow R, Justice A, Brown ST et al (2012) HIV as an independent risk factor for incident lung cancer. AIDS 26(8):1017–1025PubMed

17.

Hleyhel M, Belot A, Bouvier A-M, Tattevin P, Pacanowski J, Genet P et al (2013) Risk of AIDS-defining cancers among HIV-1-infected patients in France between 1992 and 2009: results from the FHDH-ANRS C04 Cohort. Clin Infect Dis 57(11):1638–1647PubMed

18.

Gutierrez J, Albuquerque ALA, Falzon L (2017) HIV infection as vascular risk: a systematic review of the literature and meta-analysis. PLoS One 12(5):e0176686PubMedPubMedCentral

19.

Hart BB, Nordell AD, Okulicz JF, Palfreeman A, Horban A, Kedem E et al (2018) Inflammation-related morbidity and mortality among HIV-positive adults: how extensive is it? J Acquir Immune Defic Syndr 77(1):1–7PubMedPubMedCentral

20.

Gootenberg DB, Paer JM, Luevano JM, Kwon DS (2017) HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation. Curr Opin Infect Dis 30(1):31–43PubMedPubMedCentral

21.

Turtle L, Vyakernam R, Menon-Johansson A, Nelson MR, Soni N (2011) Intensive care usage by HIV-positive patients in the HAART Era. Interdiscip Perspect Infect Dis 2011:847835PubMedPubMedCentral

22.

van Lelyveld SF, Wind CM, Mudrikova T, van Leeuwen HJ, de Lange DW, Hoepelman AI (2011) Short- and long-term outcome of HIV-infected patients admitted to the intensive care unit. Eur J Clin Microbiol Infect Dis 30(9):1085–1093PubMed

23.

Morquin D, Le Moing V, Mura T, Makinson A, Klouche K, Jonquet O et al (2012) Short- and long-term outcomes of HIV-infected patients admitted to the intensive care unit: impact of antiretroviral therapy and immunovirological status. Ann Intensive Care 2(1):25PubMedPubMedCentral

24.

Akgun KM, Tate JP, Pisani M, Fried T, Butt AA, Gibert CL et al (2013) Medical ICU admission diagnoses and outcomes in human immunodeficiency virus-infected and virus-uninfected veterans in the combination antiretroviral era. Crit Care Med 41(6):1458–1467PubMedPubMedCentral

25.

Botha J, Fabian J, Etheredge H, Conradie F, Tiemessen CT (2019) HIV and solid organ transplantation: where are we now. Curr HIV AIDS Rep 16:404–413

26.

Madan S, Patel SR, Saeed O, Sims DB, Shin JJ, Goldstein DJ et al (2019) Outcomes of heart transplantation in patients with human immunodeficiency virus. Am J Transplant. https://doi.org/10.1111/ajt.15257 CrossRefPubMed

27.

Sawinski D, Bloom RD (2014) Current status of kidney transplantation in HIV-infected patients. Curr Opin Nephrol Hypertens 23(6):619–624PubMed

28.

Lee EJ, Kim YH, Lee JY, Sunwoo JS, Park SY, Kim TH (2017) Acute HIV-1 infection presenting with fulminant encephalopathy. Int J STD AIDS 28(10):1041–1044PubMed

29.

Tattevin P, Camus C, Arvieux C, Ruffault A, Michelet C (2007) Multiple organ failure during primary HIV infection. Clin Infect Dis 44(3):e28–e29PubMed

30.

Ferrada MA, Xie Y, Nuermberger E (2015) Primary HIV infection presenting as limbic encephalitis and rhabdomyolysis. Int J STD AIDS 26(11):835–836PubMed

31.

Vandi G, Calza L, Girometti N, Manfredi R, Musumeci G, Bon I et al (2017) Acute onset myopericarditis as unusual presentation of primary HIV infection. Int J STD AIDS 28(2):199–201PubMed

32.

Dickson SJ, Batson S, Copas AJ, Edwards SG, Singer M, Miller RF (2007) Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy. Thorax 62(11):964–968PubMedPubMedCentral

33.

Barbier F, Roux A, Canet E, Martel-Samb P, Aegerter P, Wolff M et al (2014) Temporal trends in critical events complicating HIV infection: 1999–2010 multicentre cohort study in France. Intensive Care Med 40:1906–1915PubMed

34.

Cilloniz C, Torres A, Manzardo C, Gabarrus A, Ambrosioni J, Salazar A et al (2017) Community-acquired pneumococcal pneumonia in virologically suppressed HIV-infected adult patients: a matched case-control study. Chest 152(2):295–303PubMed

35.

Cilloniz C, Miguel-Escuder L, Pedro-Bonet ML, Falco V, Lopez Y, Garcia-Vidal C et al (2018) Community-acquired Legionella pneumonia in Human Immunodeficiency Virus-infected adult patients: a matched case-control study. Clin Infect Dis 67(6):958–961PubMed

36.

van Veen KE, Brouwer MC, van der Ende A, van de Beek D (2016) Bacterial meningitis in patients with HIV: a population-based prospective study. J Infect 72(3):362–368PubMed

37.

Imlay H, Kaul D, Rao K (2016) Risk factors for Clostridium difficile infection in HIV-infected patients. SAGE Open Med 4:2050312116684295PubMedPubMedCentral

38.

Sanchez TH, Brooks JT, Sullivan PS, Juhasz M, Mintz E, Dworkin MS et al (2005) Bacterial diarrhea in persons with HIV infection, United States, 1992–2002. Clin Infect Dis 41(11):1621–1627PubMed

39.

Cribbs SK, Tse C, Andrews J, Shenvi N, Martin GS (2015) Characteristics and outcomes of HIV-infected patients with severe sepsis: continued risk in the post-highly active antiretroviral therapy era. Crit Care Med 43(8):1638–1645PubMed

40.

Huson MA, Scicluna BP, van Vught LA, Wiewel MA, Hoogendijk AJ, Cremer OL et al (2016) The impact of HIV co-infection on the genomic response to sepsis. PLoS One 11(2):e0148955PubMedPubMedCentral

41.

Wiewel MA, Huson MA, van Vught LA, Hoogendijk AJ, Klein Klouwenberg PM, Horn J et al (2016) Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study. Crit Care 20(1):322PubMedPubMedCentral

42.

Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R et al (2017) Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock, 2016. Intensive Care Med 43(3):304–377PubMed

43.

Meybeck A, Lecomte L, Valette M, Van Grunderbeeck N, Boussekey N, Chiche A et al (2012) Should highly active antiretroviral therapy be prescribed in critically ill HIV-infected patients during the ICU stay? A retrospective cohort study. AIDS Res Ther 9(1):27PubMedPubMedCentral

44.

Turvey SL, Bagshaw SM, Eurich DT, Sligl WI (2017) Epidemiology and outcomes in critically ill patients with human immunodeficiency virus infection in the era of combination antiretroviral therapy. Can J Infect Dis Med Microbiol 2017:7868954PubMedPubMedCentral

45.

Mongardon N, Geri G, Deye N, Sonneville R, Boissier F, Perbet S et al (2015) Etiologies, clinical features and outcome of cardiac arrest in HIV-infected patients. Int J Cardiol 201:302–307PubMed

46.

Mendez-Tellez PA, Damluji A, Ammerman D, Colantuoni E, Fan E, Sevransky JE et al (2010) Human immunodeficiency virus infection and hospital mortality in acute lung injury patients. Crit Care Med 38(7):1530–1535PubMed

47.

Collett LW, Simpson T, Camporota L, Meadows CI, Ioannou N, Glover G et al (2018) The use of extracorporeal membrane oxygenation in HIV-positive patients with severe respiratory failure: a retrospective observational case series. Int J STD AIDS 2018:956462418805606

48.

Obata R, Azuma K, Nakamura I, Oda J (2018) Severe acute respiratory distress syndrome in a patient with AIDS successfully treated with veno-venous extracorporeal membrane oxygenation: a case report and literature review. Acute Med Surg 5(4):384–389PubMedPubMedCentral

49.

Sonneville R, Ferrand H, Tubach F, Roy C, Bouadma L, Klein IF et al (2011) Neurological complications of HIV infection in critically ill patients: clinical features and outcomes. J Infect 62(4):301–308PubMed

50.

Medrano J, Alvaro-Meca A, Boyer A, Jimenez-Sousa MA, Resino S (2014) Mortality of patients infected with HIV in the intensive care unit (2005 through 2010): significant role of chronic hepatitis C and severe sepsis. Crit Care 18(4):475PubMedPubMedCentral

51.

Barbier F, Coquet I, Legriel S, Pavie J, Darmon M, Mayaux J et al (2009) Etiologies and outcome of acute respiratory failure in HIV-infected patients. Intensive Care Med 35(10):1678–1686PubMedPubMedCentral

52.

Cilloniz C, Torres A, Polverino E, Gabarrus A, Amaro R, Moreno E et al (2014) Community-acquired lung respiratory infections in HIV-infected patients: microbial aetiology and outcome. Eur Respir J 43(6):1698–1708PubMed

53.

Segal LN, Methe BA, Nolan A, Hoshino Y, Rom WN, Dawson R et al (2011) HIV-1 and bacterial pneumonia in the era of antiretroviral therapy. Proc Am Thorac Soc 8(3):282–287PubMedPubMedCentral

54.

The Centers for Disease Control and Prevention tNIoH, the HIV Medicine Association of the Infectious Diseases Society of America. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. http://www.aidsinfo.nih.gov. Accessed 1 Nov 2019

55.

Pannetier J, Ravalihasy A, Lydie N, Lert F, du Lou DA (2018) Prevalence and circumstances of forced sex and post-migration HIV acquisition in sub-Saharan African migrant women in France: an analysis of the ANRS-PARCOURS retrospective population-based study. Lancet Public Health 3(1):e16–e23PubMed

56.

McCarthy AE, Weld LH, Barnett ED, So H, Coyle C, Greenaway C et al (2013) Spectrum of illness in international migrants seen at GeoSentinel clinics in 1997–2009, part 2: migrants resettled internationally and evaluated for specific health concerns. Clin Infect Dis 56(7):925–933PubMed

57.

Roux A, Canet E, Valade S, Gangneux-Robert F, Hamane S, Lafabrie A et al (2014) Pneumocystis jirovecii pneumonia in patients with or without AIDS, France. Emerg Infect Dis 20(9):1490–1497PubMedPubMedCentral

58.

Miller RF, Walzer PD, Smulian AG (2019) Pneumocystis species—Chapter 269 in: Mandell, Douglas and Benett’s Principles and practices of infectious diseases, 9th edn. In: Benett JE, Dolin R, Blaser MJ (eds) Elsiever Science, Amsterdam

59.

Morris A, Wei K, Afshar K, Huang L (2008) Epidemiology and clinical significance of pneumocystis colonization. J Infect Dis 197(1):10–17PubMed

60.

Louis M, Guitard J, Jodar M, Ancelle T, Magne D, Lascols O et al (2015) Impact of HIV infection status on interpretation of quantitative PCR for detection of Pneumocystis jirovecii. J Clin Microbiol 53(12):3870–3875PubMedPubMedCentral

61.

Fauchier T, Hasseine L, Gari-Toussaint M, Casanova V, Marty PM, Pomares C (2016) Detection of Pneumocystis jirovecii by quantitative PCR to differentiate colonization and pneumonia in immunocompromised HIV-positive and HIV-negative patients. J Clin Microbiol 54(6):1487–1495PubMedPubMedCentral

62.

Li WJ, Guo YL, Liu TJ, Wang K, Kong JL (2015) Diagnosis of pneumocystis pneumonia using serum (1-3)-beta-D-Glucan: a bivariate meta-analysis and systematic review. J Thorac Dis 7(12):2214–2225PubMedPubMedCentral

63.

Onishi A, Sugiyama D, Kogata Y, Saegusa J, Sugimoto T, Kawano S et al (2012) Diagnostic accuracy of serum 1,3-beta-d-glucan for Pneumocystis jirovecii pneumonia, invasive candidiasis, and invasive aspergillosis: systematic review and meta-analysis. J Clin Microbiol 50(1):7–15PubMedPubMedCentral

64.

Wieruszewski PM, Barreto JN, Frazee E, Daniels CE, Tosh PK, Dierkhising RA et al (2018) Early corticosteroids for Pneumocystis pneumonia in adults without HIV are not associated with better outcome. Chest 154(3):636–644PubMed

65.

Lemiale V, Debrumetz A, Delannoy A, Alberti C, Azoulay E (2013) Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia. Respir Res 14:87PubMedPubMedCentral

66.

Ewald H, Raatz H, Boscacci R, Furrer H, Bucher HC, Briel M (2015) Adjunctive corticosteroids for Pneumocystis jirovecii pneumonia in patients with HIV infection. Cochrane Database Syst Rev 4:CD006150

67.

Lanoix JP, Gaudry S, Flicoteaux R, Ruimy R, Wolff M (2014) Tuberculosis in the intensive care unit: a descriptive analysis in a low-burden country. Int J Tuberc Lung Dis 18(5):581–587PubMed

68.

Dorman SE, Schumacher SG, Alland D, Nabeta P, Armstrong DT, King B et al (2018) Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis 18(1):76–84PubMedPubMedCentral

69.

Critchley JA, Young F, Orton L, Garner P (2013) Corticosteroids for prevention of mortality in people with tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 13(3):223–237PubMed

70.

Yang JY, Han M, Koh Y, Kim WS, Song JW, Oh YM et al (2016) Effects of corticosteroids on critically ill pulmonary tuberculosis patients with acute respiratory failure: a propensity analysis of mortality. Clin Infect Dis 63(11):1449–1455PubMed

71.

Sonneville R, Magalhaes E, Meyfroidt G (2017) Central nervous system infections in immunocompromised patients. Curr Opin Crit Care 23(2):128–133PubMed

72.

Sonneville R, Schmidt M, Messika J, Ait Hssain A, da Silva D, Klein IF et al (2012) Neurologic outcomes and adjunctive steroids in HIV patients with severe cerebral toxoplasmosis. Neurology 79(17):1762–1766PubMed

73.

Cantier M, Morisot A, Guerot E, Megarbane B, Razazi K, Contou D et al (2018) Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study. Crit Care 22(1):210PubMedPubMedCentral

74.

Heemskerk AD, Bang ND, Mai NT, Chau TT, Phu NH, Loc PP et al (2016) Intensified antituberculosis therapy in adults with tuberculous meningitis. N Engl J Med 374(2):124–134PubMed

75.

Prasad K, Singh MB, Ryan H (2016) Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev 4:CD002244PubMed

76.

Day JN, Chau TT, Lalloo DG (2013) Combination antifungal therapy for cryptococcal meningitis. N Engl J Med 368(26):2522–2523PubMed

77.

Beardsley J, Wolbers M, Kibengo FM, Ggayi AB, Kamali A, Cuc NT et al (2016) Adjunctive dexamethasone in HIV-associated cryptococcal meningitis. N Engl J Med 374(6):542–554PubMedPubMedCentral

78.

Vandenhende MA, Roussillon C, Henard S, Morlat P, Oksenhendler E, Aumaitre H et al (2015) Cancer-related causes of death among HIV-infected patients in France in 2010: evolution since 2000. PLoS One 10(6):e0129550PubMedPubMedCentral

79.

Ramaswami R, Chia G, Dalla Pria A, Pinato DJ, Parker K, Nelson M et al (2016) Evolution of HIV-associated lymphoma over three decades. J Acquir Immune Defic Syndr 72(2):177–183PubMed

80.

Gerard L, Meignin V, Galicier L, Fieschi C, Leturque N, Piketty C et al (2009) Characteristics of non-Hodgkin lymphoma arising in HIV-infected patients with suppressed HIV replication. AIDS 23(17):2301–2308PubMed

81.

Algrin C, Faguer S, Lemiale V, Lengline E, Boutboul D, Amorim S et al (2015) Outcomes after intensive care unit admission of patients with newly diagnosed lymphoma. Leuk Lymphoma 56(5):1240–1245PubMed

82.

Fardet L, Lambotte O, Meynard JL, Kamouh W, Galicier L, Marzac C et al (2010) Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis. AIDS 24(9):1299–1306PubMed

83.

Canet E, Zafrani L, Lambert J, Thieblemont C, Galicier L, Schnell D et al (2013) Acute kidney injury in patients with newly diagnosed high-grade hematological malignancies: impact on remission and survival. PLoS One 8(2):e55870PubMedPubMedCentral

84.

Bigenwald C, Fardet L, Coppo P, Meignin V, Lazure T, Fabiani B et al (2018) A comprehensive analysis of lymphoma-associated haemophagocytic syndrome in a large French multicentre cohort detects some clues to improve prognosis. Br J Haematol 183(1):68–75PubMed

85.

Zafrani L, Canet E, Darmon M (2019) Understanding tumor lysis syndrome. Intensive Care Med 45(11):1608–1611. https://doi.org/10.1007/s00134-019-05768-x CrossRefPubMed

86.

Barta SK, Xue X, Wang D, Tamari R, Lee JY, Mounier N et al (2013) Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: a pooled analysis of 1546 patients. Blood 122(19):3251–3262PubMedPubMedCentral

87.

Gerard L, Galicier L, Maillard A, Boulanger E, Quint L, Matheron S et al (2002) Systemic non-Hodgkin lymphoma in HIV-infected patients with effective suppression of HIV replication: persistent occurrence but improved survival. J Acquir Immune Defic Syndr 30(5):478–484PubMed

88.

Montoto S, Shaw K, Okosun J, Gandhi S, Fields P, Wilson A et al (2012) HIV status does not influence outcome in patients with classical Hodgkin lymphoma treated with chemotherapy using doxorubicin, bleomycin, vinblastine, and dacarbazine in the highly active antiretroviral therapy era. J Clin Oncol 30(33):4111–4116PubMedPubMedCentral

89.

Ferre C, de Guzmao BM, Morgades M, Lacoma A, Marcos P, Jimenez-Lorenzo MJ et al (2012) Lack of impact of human immunodeficiency virus infection on the outcome of lymphoma patients transferred to the intensive care unit. Leuk Lymphoma 53(10):1966–1970PubMed

90.

Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N et al (2015) Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma. Ann Oncol 26(5):958–966PubMedPubMedCentral

91.

Dittmer DP, Damania B (2019) Kaposi’s sarcoma-associated herpesvirus (KSHV)-associated disease in the AIDS patient: an update. Cancer Treat Res 177:63–80PubMedPubMedCentral

92.

Yarchoan R, Uldrick TS (2018) HIV-associated cancers and related diseases. N Engl J Med 378(22):2145PubMed

93.

Oksenhendler E, Boutboul D, Fajgenbaum D, Mirouse A, Fieschi C, Malphettes M et al (2018) The full spectrum of Castleman disease: 273 patients studied over 20 years. Br J Haematol 180(2):206–216PubMed

94.

Oksenhendler E, Carcelain G, Aoki Y, Boulanger E, Maillard A, Clauvel JP et al (2000) High levels of HHV8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients. Blood 96(6):2069–2073PubMed

95.

Gerard L, Michot JM, Burcheri S, Fieschi C, Longuet P, Delcey V et al (2012) Rituximab decreases the risk of lymphoma in patients with HIV-associated multicentric Castleman disease. Blood 119(10):2228–2233PubMed

96.

Manzardo C, Guardo AC, Letang E, Plana M, Gatell JM, Miro JM (2015) Opportunistic infections and immune reconstitution inflammatory syndrome in HIV-1-infected adults in the combined antiretroviral therapy era: a comprehensive review. Expert Rev Anti Infect Ther 13(6):751–767PubMed

97.

Muller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M (2010) Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis. Lancet Infect Dis 10(4):251–261PubMedPubMedCentral

98.

The Centers for Disease Control and Prevention, the National Institutes of Health, America atIDSo. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. http://www.aidsinfo.nih.gov. Accessed 1 Nov 2019

99.

Andrade HB, Shinotsuka CR, da Silva IRF, Donini CS, Yeh Li H, de Carvalho FB et al (2017) Highly active antiretroviral therapy for critically ill HIV patients: a systematic review and meta-analysis. PLoS One 12(10):e0186968PubMedPubMedCentral

100.

May MT, Gompels M, Delpech V, Porter K, Orkin C, Kegg S et al (2014) Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy. AIDS 28(8):1193–1202PubMed

101.

The Antiretroviral Therapy Cohort Collaboration (2017) Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies. Lancet HIV 4(8):e349–e356

102.

Nsanzimana S, Remera E, Kanters S, Chan K, Forrest JI, Ford N et al (2015) Life expectancy among HIV-positive patients in Rwanda: a retrospective observational cohort study. Lancet Glob Health 3(3):e169–e177PubMed

103.

Bhatta DN, Adhikari R, Karki S, Koirala AK, Wasti SP (2019) Life expectancy and disparities in survival among HIV-infected people receiving antiretroviral therapy: an observational cohort study in Kathmandu, Nepal. BMJ Glob Health 4(3):e001319PubMedPubMedCentral

104.

Meintjes G, Moorhouse MA, Carmona S, Davies N, Dlamini S, van Vuuren C et al (2017) Adult antiretroviral therapy guidelines 2017. S Afr J HIV Med 18(1):776

105.

Chawla A, Wang C, Patton C, Murray M, Punekar Y, de Ruiter A et al (2018) A review of long-term toxicity of antiretroviral treatment regimens and implications for an aging population. Infect Dis Ther 7(2):183–195PubMedPubMedCentral

106.

Lopes JA, Melo MJ, Raimundo M, Fragoso A, Antunes F (2013) Long-term risk of mortality for acute kidney injury in HIV-infected patients: a cohort analysis. BMC Nephrol 14:32PubMedPubMedCentral

107.

Venter WDF, Moorhouse M, Sokhela S, Fairlie L, Mashabane N, Masenya M et al (2019) Dolutegravir plus two different prodrugs of tenofovir to treat HIV. N Engl J Med 381(9):803–815PubMed

108.

Teeraananchai S, Kerr SJ, Amin J, Ruxrungtham K, Law MG (2017) Life expectancy of HIV-positive people after starting combination antiretroviral therapy: a meta-analysis. HIV Med 18(4):256–266PubMed

109.

Crum-Cianflone N (2013) Critical crossroads in the care of human immunodeficiency virus-infected persons*. Crit Care Med 41(6):1579–1580PubMed

Titel: Management of HIV-infected patients in the intensive care unit
verfasst von: François Barbier
Mervin Mer
Piotr Szychowiak
Robert F. Miller
Éric Mariotte
Lionel Galicier
Lila Bouadma
Pierre Tattevin
Élie Azoulay
Publikationsdatum: 03.02.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 2/2020
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-020-05945-3

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