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Pediatric Drugs

Erschienen in:

01.02.2012 | Review Article

Management of Pediatric Eosinophilic Esophagitis

An Update

verfasst von: Dr Seema Khan

Erschienen in: Pediatric Drugs | Ausgabe 1/2012

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Abstract

Eosinophilic esophagitis is an important chronic esophageal disorder with gastroesophageal reflux disease (GERD)-like symptoms, prominent esophageal mucosal eosinophilia, strongly associated with allergic disorders and unresponsive to anti-GERD therapy. Treatment of eosinophilic esophagitis has been successful with the use of dietary restrictions and topical corticosteroids. A subset of patients benefits from concurrent anti-GERD therapy; those with demonstrable esophageal strictures report variable duration symptom relief after esophageal dilation. At the current time, anti-interleukin-5 monoclonal antibody agents are being investigated in multicenter trials, and it is hoped that future therapy may be targeted against mediators of esophageal remodeling and fibrosis in eosinophilic esophagitis.

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Titel: Management of Pediatric Eosinophilic Esophagitis
An Update
verfasst von: Dr Seema Khan
Publikationsdatum: 01.02.2012
Verlag: Springer International Publishing
Erschienen in: Pediatric Drugs / Ausgabe 1/2012
Print ISSN: 1174-5878
Elektronische ISSN: 1179-2019
DOI: https://doi.org/10.2165/11595210-000000000-00000

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