Introduction
Materials and methods
Samples
ID/age at D | Biological Material | PTC Histologic variant | pTNM | Mutations | % of mutant alleles | Rearrangements | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BRAF
|
TERT
|
KRAS
|
HRAS
|
NRAS
|
AKT
|
PIK3CA
|
RET/PTC
|
N-TRK
| |||||
1/87 | FS/FFPE | classical | pT3NXM0 |
V600E
| WT | WT | WT | WT | WT | WT |
11
a
/8
| WT | WT |
2/69 | FS/FFPE | classical | pT3mN1bM0 |
V600E
|
G228A
| WT | WT | WT | WT | WT |
30
(
BRAF
)
a
/35 34
(
TERT
)
a
/34
| WT | WT |
3/63 | FS | classical | pT3mN1aM0 | WT | WT | WT | WT | WT | WT | WT |
RET/PTC1
a
| WT | |
4/33 | FS | classical | pT3mN1bM0 | WT | WT | WT | WT | WT | WT | WT |
RET/PTC3
a
| WT | |
5/52 | FS/FFPE | follicular | pT3mNXM0 | WT | WT | WT | WT |
Q61R
| WT | WT |
26
a
/25
| WT | WT |
6/56 | FS/FFPE | follicular | pT3mN1bM1 | WT |
G250A
| WT | WT | WT | WT | WT |
24/22
|
RET/PTC3
| WT |
7/61 | FS | follicular | pT2N0M0 | WT | WT | WT |
Q61K
| WT | WT | WT |
53
| WT | WT |
8/60 | FS/FFPE | classical | pT1N0M0 | WT | WT | WT | WT |
Q61K
| WT | WT |
33
a
/35
| WT | WT |
9/74 | FS | classical | pT3mN1bM0 | WT |
G228A
| WT | WT | WT | WT | WT |
47
| WT | WT |
10/68 | FS | Classical/follicular | pT4mN1bM0 |
V600E
|
G228A
| WT | WT | WT | WT | WT |
21
(
BRAF
)
a
24
(
TERT
)
a
| WT | WT |
11/41 | FS | follicular | pT3N1bM0 | WT | WT | WT | WT | WT | WT | WT | – |
RET/PTC1
| WT |
12/22 | FS | classical | pT1N1aM0 | WT | WT | WT | WT | WT | WT | WT | – |
RET/PTC3
| WT |
13/56 | FFPE | classical | pT1N1aM0 | WT | WT | WT | WT |
Q61R
| WT | WT |
20
a
| WT | WT |
14/83 | FFPE | classical | pT3mNXM0 | WT | WT | WT | WT |
Q61K
| WT | WT |
28
a
| WT | WT |
15/27 | FFPE | classical | pT3mN1bM0 | WT | WT | WT |
Q61R
| WT | WT | WT |
48
| WT | WT |
16/62 | FFPE | classical | pT3mN0M0 |
V600E
| WT | WT | WT | WT | WT | WT |
27
| WT | WT |
17/35 | FFPE | classical | pT1mN1aM0 |
V600E
| WT | WT | WT | WT | WT | WT |
19
| WT | WT |
18 /28 | FFPE | classical | pT2mN1aM0 |
V600E
| WT | WT | WT | WT | WT | WT |
29
| WT | WT |
19/50 | FFPE | classical | pT3mN0M0 |
V600E
|
G228A
| WT | WT | WT | WT | WT |
15
(
BRAF
)
23
(
TERT
)
| WT | WT |
20/41 | FFPE | classical | pT1mNXM0 | WT |
G228A
| WT | WT | WT | WT | WT |
37
| WT | WT |
21/35 | FFPE | classical | pT3mN1aM0 | WT |
G228A
| WT | WT | WT | WT | WT |
29
| WT | WT |
22/28 | FFPE | follicular | pT2mNXM0 | WT | WT | WT | WT |
Q61R
| WT | WT |
12
| WT | WT |
23/35 | FFPE | classical | pT2N1aM0 | WT | WT | WT | WT | WT | WT | WT |
RET/PTC1
| WT | |
24 | cell line | – | – | WT | WT | WT | WT | WT | WT | WT | WT |
TRK
| |
25 | cell line | – | – | WT | WT | WT | WT | WT | WT | WT | WT |
TRK-T1
| |
26 | cell line | – | – | WT | WT | WT | WT | WT | WT | WT | WT |
TRK-T3
| |
27 | cell line | – | – | WT | WT | WT | WT | WT | WT | WT |
RET/PTC2
| WT | |
28 | FFPE; C + | – | – | WT | WT | WT | WT | WT |
E17K
| WT |
46
| WT | WT |
29 | FFPE; C+ | – | – | WT | WT |
G12V
| WT | WT | WT | WT |
48
a
| WT | WT |
30 | FFPE; C+ | – | – | WT | WT |
G13C
| WT | WT | WT | WT |
54
a
| WT | WT |
31 | FFPE; C+ | – | – | WT | WT | WT | WT | WT | WT |
E542K
|
72
| WT | WT |