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Erschienen in:
21.08.2017 | Short Communication
Maternal consumption of quinine-containing sodas may induce G6PD crises in breastfed children
Erschienen in: European Journal of Pediatrics | Ausgabe 10/2017
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect often presenting with neonatal jaundice and/or hemolytic anemia. G6PD hemolytic events are linked with exposure to a pro-oxidant agent. We here report three cases of initial G6PD crises in breastfed children secondary to maternal consumption of a tonic drink which contains quinine. Quinine was found in breast milk of one of the mothers after she consumed tonic water.
Conclusion: The amount of quinine that is transmitted through breast milk appears to be sufficient to induce G6PD crises in breastfed children. We hence recommend that consumption of quinine-containing sodas during breastfeeding should be avoided in populations with a high prevalence of G6PD deficiency.
What is Known:
• G6PD hemolytic events are linked with exposure to a pro-oxidant agent.
• Ingestion of fava beans by a mother who was breastfeeding has been reported to induce a neonatal G6PD crisis.
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What is New:
• Maternal consumption of tonic drink which contains quinine appears to be sufficient to induce G6PD crises in breastfed children.
• Maternal consumption of quinine-containing sodas during breastfeeding should be avoided in populations with a high prevalence of G6PD deficiency.
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