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Archives of Gynecology and Obstetrics

Erschienen in:

02.12.2016 | Maternal-Fetal Medicine

Maxillary length in euploid and aneuploid fetuses

verfasst von: Markus Hoopmann, Jiri Sonek, Dominik Goldschmid, Philipp Wagner, Harald Abele, Karl Oliver Kagan

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 2/2017

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Abstract

Purpose

To examine the maxillary length of euploid and aneuploid fetuses in the second and third trimester.

Methods

Retrospective study utilizing stored 2D images of second and third trimester fetal profiles obtained at the University of Tuebingen, Germany. The length of the maxilla was measured as a straight line between the anterior ventral and posterior ventral edges of the maxilla.

Results

The study population consisted of 347 euploid fetuses and 122, 36, 5, 8, and 4 fetuses with trisomy 21, 18, and 13, Turner syndrome, and triploidy. In the euploid and aneuploid group, mean gestational age was 22.3 and 22.7 weeks, respectively. The maxilla length in euploid fetuses was significantly dependent on gestational age and it was significantly shorter in fetuses with trisomy 21, 18, and 13, and triploidy but not in those with Turner syndrome. In 75.4 and 14.8%, and 11 fetuses with trisomy 21, the maxilla was below the mean, the 5th and 1st centile of the euploid population.

Conclusions

In fetuses with trisomy 21, 18, and 13 and triploidy, the maxilla is significantly shorter, but the difference is only settled, so that it is unlikely that the maxilla length will play a role in second and third screening for aneuploidy.

Sonek JD, Wagner P, Nicolaides KH (2016) Inverted Pyramid of Care. Clin Lab Med. 36(2):305–317CrossRefPubMed

Cicero S (2003) Sonographic markers of fetal aneuploidy?A review. Placenta 24:S88–S98CrossRefPubMed

Agathokleous M, Chaveeva P, Poon LCY, Kosinski P, Nicolaides KH (2013) Meta-analysis of second-trimester markers for trisomy 21. Ultrasound Obstet Gynecol 41(3):247–261CrossRefPubMed

Sonek J, Borenstein M, Downing C, McKenna D, Neiger R, Croom C et al (2007) Frontomaxillary facial angles in screening for trisomy 21 at 14–23 weeks’ gestation. Am J Obstet Gynecol. 197(2):160.e1–160.e5CrossRef

Yazdi B, Sonek J, Oettling C, Hoopmann M, Abele H, Schaelike M et al (2013) Prefrontal space ratio in second- and third-trimester screening for trisomy 21. Ultrasound Obstet Gynecol 41(3):262–266CrossRefPubMed

Vos FI, De Jong-Pleij EAP, Bakker M, Tromp E, Pajkrt E, Kagan KO et al (2015) Nasal bone length, prenasal thickness, prenasal thickness-to-nasal bone length ratio and prefrontal space ratio in second- and third-trimester fetuses with Down syndrome. Ultrasound Obstet Gynecol 45(2):211–216CrossRefPubMed

Chaveeva P, Agathokleous M, Poon LCY, Markova D, Nicolaides KH (2013) Second-trimester screening for trisomy-21 using prefrontal space ratio. Fetal Diagn Ther 34(1):50–55CrossRefPubMed

De Jong-Pleij EAP, Vos FI, Ribbert LSM, Pistorius LR, Tromp E, Bilardo CM (2011) Prenasal thickness-to-nasal bone length ratio: a strong and simple second- and third-trimester marker for trisomy 21. Ultrasound Obstet Gynecol 39(2):185–190CrossRefPubMed

Suri S, Tompson BD, Atenafu E (2011) Prevalence and patterns of permanent tooth agenesis in Down syndrome and their association with craniofacial morphology. Angle Orthod 81(2):260–269CrossRefPubMed

10.

Lomholt JF, Russell BG, Stoltze K, Kjaer I (2002) Third molar agenesis in Down syndrome. Acta Odontol Scand 60(3):151–154CrossRefPubMed

11.

Shapira J, Chaushu S, Becker A (2000) Prevalence of tooth transposition, third molar agenesis, and maxillary canine impaction in individuals with Down syndrome. Angle Orthod 70(4):290–296PubMed

12.

Cicero S, Curcio P, Rembouskos G, Sonek J, Nicolaides KH (2004) Maxillary length at 11–14 weeks of gestation in fetuses with trisomy 21. Ultrasound Obstet Gynecol 24(1):19–22CrossRefPubMed

13.

Kagan KO, Sonek J, Berg X, Berg C, Mallmann M, Abele H et al (2015) Facial markers in second- and third-trimester fetuses with trisomy 18 or 13, triploidy or Turner syndrome. Ultrasound Obstet Gynecol 46(1):60–65CrossRefPubMed

14.

Wagner N, Wagner P, Haen S, Schmidt S, Yerlikaya G, Maden Z et al (2014) Effective management and intrauterine treatment of congenital cytomegalovirus infection: review article and case series. J Matern Fetal Neonatal Med. 27(2):209–214CrossRefPubMed

15.

Hermann NV, Darvann TA, Sundberg K, Kreiborg S, Joergensen C (2015) Maxillary length in 11- to 26-week-old normal fetuses studied by 3D ultrasound. Prenat Diagn 35(6):571–576CrossRefPubMed

16.

Dagklis T, Borenstein M, Peralta CFA, Faro C, Nicolaides KH (2006) Three-dimensional evaluation of mid-facial hypoplasia in fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks of gestation. Ultrasound Obstet Gynecol 28(3):261–265CrossRefPubMed

17.

Cossellu G, Persico N, D’Ambrosi F, Carbone F, Fabietti I, Boito S et al (2016) Sphenofrontal distance on three-dimensional ultrasound in euploid and trisomy-21 fetuses at 16–24 weeks’ gestation. Ultrasound Obstet Gynecol 48(2):177–180CrossRefPubMed

18.

Maymon R, Levinsohn-Tavor O, Cuckle H, Tovbin Y, Dreazen E, Wiener Y et al (2005) Second trimester ultrasound prenasal thickness combined with nasal bone length: a new method of Down syndrome screening. Prenat Diagn 25(10):906–911CrossRefPubMed

19.

Sonek J, Molina F, Hiett AK, Glover M, McKenna D, Nicolaides KH (2012) Prefrontal space ratio: comparison between trisomy 21 and euploid fetuses in the second trimester. Ultrasound Obstet Gynecol 40(3):293–296CrossRefPubMed

20.

Molina F, Persico N, Borenstein M, Sonek J, Nicolaides KH (2008) Frontomaxillary facial angle in trisomy 21 fetuses at 16–24 weeks of gestation. Ultrasound Obstet Gynecol 31(4):384–387CrossRefPubMed

21.

Gil MM, Quezada MS, Revello R, Akolekar R, Nicolaides KH (2015) Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol 45(3):249–266CrossRefPubMed

22.

Kagan KO, Hoopmann M, Singer S, Schaeferhoff K, Dufke A, Mau-Holzmann UA (2016) Discordance between ultrasound and cell free DNA screening for monosomy X. Arch Gynecol Obstet 294(2):219–224CrossRefPubMed

Titel: Maxillary length in euploid and aneuploid fetuses
verfasst von: Markus Hoopmann
Jiri Sonek
Dominik Goldschmid
Philipp Wagner
Harald Abele
Karl Oliver Kagan
Publikationsdatum: 02.12.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 2/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4251-2

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Maxillary length in euploid and aneuploid fetuses