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Immunologic Research

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06.01.2016 | Original Article

MBL2 genetic polymorphisms and HIV-1 mother-to-child transmission in Zambia

verfasst von: Luisa Zupin, Vania Polesello, Ludovica Segat, Louise Kuhn, Sergio Crovella

Erschienen in: Immunologic Research | Ausgabe 3/2016

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Abstract

Since antiretroviral drugs have been introduced to prevent mother-to-child transmission, the risk of HIV-1 infection in infants has decreased considerably worldwide. Nevertheless, many factors are involved in viral transmission and host susceptibility to infection. The immune system and its components, including mannose binding protein C (encoding by MBL2 gene), are already known to play an important role in this scenario. In the present study, 313 children and 98 of their mothers from Zambia were genotyped for the MBL2 promoter HL (rs11003125) and XY (rs7096206) polymorphisms and exon 1 D (rs5030737, at codon 52) B (rs1800450, at codon 54) and C (rs1800451, at codon 57) polymorphisms in order to investigate the potential role of these genetic variants in HIV-1 mother-to-child transmission. No statistical significant association was observed comparing transmitter and non-transmitter mothers and also confronting HIV-positive and HIV-negative children. The findings of the current study obtained on mother and children from Zambia evidence lack of association between MBL2 functional polymorphisms and HIV-1 mother-to-child transmission.

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Titel: MBL2 genetic polymorphisms and HIV-1 mother-to-child transmission in Zambia
verfasst von: Luisa Zupin
Vania Polesello
Ludovica Segat
Louise Kuhn
Sergio Crovella
Publikationsdatum: 06.01.2016
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 3/2016
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-015-8779-1

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MBL2 genetic polymorphisms and HIV-1 mother-to-child transmission in Zambia

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