Erschienen in:
01.05.2008 | Poster presentation
MCPH1, a potential predictor for response to cancer chemotherapy
verfasst von:
SM Bell, V Speirs, EE Morrison
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2008
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Excerpt
We previously identified MCPH1, a DNA damage response protein involved in the regulation of the breast cancer tumour suppressor gene
BRCA1, as the defective protein in one form of microcephaly [
1]. We found that reduced expression of MCPH1 causes premature chromosome condensation (PCC) [
2]. PCC is a hallmark of mammalian cells that begin mitosis before completing DNA replication. The
MCPH1 locus (8p22-p23) is frequently deleted in many tumour types and this is associated with a poor prognosis and a reduced response to chemotherapy in breast cancer [
3]. Many chemotherapeutic agents such as taxanes (for example, Taxol) require a functional spindle checkpoint for the induction of apoptosis in cancer cells. …