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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.03.2011 | Review Article

Measuring macular pigment optical density in vivo: a review of techniques

verfasst von: Olivia Howells, Frank Eperjesi, Hannah Bartlett

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 3/2011

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Abstract

Background

Macular pigment has been the focus of much attention in recent years, as a potential modifiable risk factor for age-related macular degeneration. This interest has been heightened by the ability to measure macular pigment optical density (MPOD) in vivo.

Method

A systematic literature search was undertaken to identify all available papers that have used in vivo MPOD techniques. The papers were reviewed, and all relevant information was incorporated into this article.

Results

Measurement of MPOD is achievable with a wide range of techniques, which are typically categorized into one of two groups: psychophysical (requiring a response from the subject) or objective (requiring minimal input from the subject). The psychophysical methods include heterochromatic flicker photometry and minimum motion photometry. The objective methods include fundus reflectometry, fundus autofluorescence, resonance Raman spectroscopy and visual evoked potentials. Even within the individual techniques, there is often much variation in how data is obtained and processed.

Conclusion

This review comprehensively details the procedure, instrumentation, assumptions, validity and reliability of each MPOD measurement technique currently available, along with their respective advantages and disadvantages. This leads us to conclude that development of a commercial instrument, based on fundus reflectometry or fundus autofluorescence, would be beneficial to macular pigment research and would support MPOD screening in a clinical setting.

(The data from Wyszecki and Stiles [118] is actually a weighted composite curve of six psychophysical methods that had been used up to that time, rather than in vitro data.

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Titel: Measuring macular pigment optical density in vivo: a review of techniques
verfasst von: Olivia Howells
Frank Eperjesi
Hannah Bartlett
Publikationsdatum: 01.03.2011
Verlag: Springer-Verlag
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 3/2011
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-010-1577-5

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Measuring macular pigment optical density in vivo: a review of techniques

Abstract

Background

Method

Results

Conclusion

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Abstract

Background

Method

Results

Conclusion

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