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02.02.2016 | Original Article

Mechanical properties of bone tissues surrounding dental implant systems with different treatments and healing periods

verfasst von: Do-Gyoon Kim, Hyun-Jung Kwon, Yong-Hoon Jeong, Erin Kosel, Damian J. Lee, Jung-Suk Han, Hye-Lee Kim, Dae-Joon Kim

Erschienen in: Clinical Oral Investigations | Ausgabe 8/2016

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Abstract

Objectives

The objective of the current study was to examine whether the nanoindentation parameters can assess the alteration of bone quality resulting from different degrees of bone remodeling between bone tissue ages around the dental implant interface with different treatments and healing periods.

Materials and methods

Dental implants were placed in mandibles of six male dogs. Treatment groups included: resorbable blast media-treated titanium (Ti) implants, alumina-blasted zirconia implants (ATZ), alumina-blasted zirconia implants applied with demineralized bone matrix (ATZ-D), and alumina-blasted zirconia implants applied with rhBMP-2 (ATZ-B). Nanoindentation modulus (E), hardness (H), viscosity (η), and viscoelastic creep (Creep/P _max) were measured for new and old bone tissues adjacent to the implants at 3 and 6 weeks of post-implantation. A total of 945 indentations were conducted for 32 implant systems.

Results

Significantly lower E, H, and η but higher Creep/P _max were measured for new bone tissues than old bone tissues, independent of treatments at both healing periods (p < 0.001). All nanoindentation parameters were not significantly different between healing periods (p > 0.568). ATZ-D and ATZ-B implants had the stiffer slope of correlation between E and Creep/P _max of the new bone tissue than Ti implant (p < 0.039).

Conclusions

Current results indicated that, in addition to elastic modulus and plastic hardness, measurement of viscoelastic properties of bone tissue surrounding the implant can provide more detailed information to understand mechanical behavior of an implant system.

Clinical relevance

Ability of energy absorption in the interfacial bone tissue can play a significant role in the long-term success of a dental implant system.

Isidor F (2006) Influence of forces on peri-implant bone. Clin Oral Implants Res 17(Supplement 2):8–18. doi:10.1111/j.1600-0501.2006.01360.x CrossRef

Hoshaw SJ, Brunski JB, Cochran GV (1994) Mechanical loading of Brånemark implants affects interfacial bone modeling and remodeling. Int J Oral Max Impl 9(3):345–360

Lin D, Li Q, Li W, Duckmanton N, Swain M (2010) Mandibular bone remodeling induced by dental implant. J Biomech 43(2):287–293. doi:10.1016/j.jbiomech.2009.08.024 PubMedCrossRef

Kim DG, Huja SS, Tee BC, Larsen PE, Kennedy KS, Chien HH, Lee JW, Wen HB (2013a) Bone ingrowth and initial stability of titanium and porous tantalum dental implants: a pilot canine study. Implant Dent 22(4):399–405. doi:10.1097/ID.0b013e31829b17b5 PubMedCrossRef

Brunski JB (1988) Biomaterials and biomechanics in dental implant design. The Int J Oral Max Impl 3(2):85–97

Baldassarri M, Bonfante E, Suzuki M, Marin C, Granato R, Tovar N, Coelho PG (2012) Mechanical properties of human bone surrounding plateau root form implants retrieved after 0.3–24 years of function. J Biomed Mater Res B Appl Biomater 100(7):2015–2021. doi:10.1002/jbm.b.32786 PubMedCrossRef

Lee BC, Yeo IS, Kim DJ, Lee JB, Kim SH, Han JS (2013) Bone formation around zirconia implants combined with rhBMP-2 gel in the canine mandible. Clin Oral Implants Res 24(12):1332–1338. doi:10.1111/clr.12004 PubMedCrossRef

Piattelli A, Artese L, Penitente E, Iaculli F, Degidi M, Mangano C, Shibli JA, Coelho PG, Perrotti V, Iezzi G (2014) Osteocyte density in the peri-implant bone of implants retrieved after different time periods (4 weeks to 27 years). J Biomed Mater Res B Appl Biomater 102(2):239–243. doi:10.1002/jbm.b.33000 PubMedCrossRef

Garetto LP, Chen J, Parr JA, Roberts WE (1995) Remodeling dynamics of bone supporting rigidly fixed titanium implants: a histomorphometric comparison in four species including humans. Implant Dent 4(4):235–243PubMedCrossRef

10.

Maimoun L, Brennan TC, Badoud I, Dubois-Ferriere V, Rizzoli R, Ammann P (2010) Strontium ranelate improves implant osseointegration. Bone 46(5):1436–1441. doi:10.1016/j.bone.2010.01.379 PubMedCrossRef

11.

Anchieta RB, Baldassarri M, Guastaldi F, Tovar N, Janal MN, Gottlow J, Dard M, Jimbo R, Coelho PG (2013) Mechanical property assessment of bone healing around a titanium-zirconium alloy dental implant. Clin Implant Dent Relat Res. doi:10.1111/cid.12061

12.

Jimbo R, Coelho PG, Bryington M, Baldassarri M, Tovar N, Currie F, Hayashi M, Janal MN, Andersson M, Ono D, Vandeweghe S, Wennerberg A (2012) Nano hydroxyapatite-coated implants improve bone nanomechanical properties. J Dent Res 91(12):1172–1177. doi:10.1177/0022034512463240 PubMedCrossRef

13.

Morris MD, Mandair GS (2011) Raman assessment of bone quality. Clin Orthop Relat Res 469(8):2160–2169. doi:10.1007/s11999-010-1692-y PubMedCrossRef

14.

Gottlow J, Dard M, Kjellson F, Obrecht M, Sennerby L (2012) Evaluation of a new titanium-zirconium dental implant: a biomechanical and histological comparative study in the mini pig. Clin Implant Dent Relat Res 14(4):538–545. doi:10.1111/j.1708-8208.2010.00289.x PubMedCrossRef

15.

Shin D, Blanchard SB, Ito M, Chu TM (2011) Peripheral quantitative computer tomographic, histomorphometric, and removal torque analyses of two different non-coated implants in a rabbit model. Clin Oral Implants Res 22(3):242–250. doi:10.1111/j.1600-0501.2010.01980.x PubMedCrossRef

16.

Wikesjo UM, Huang YH, Xiropaidis AV, Sorensen RG, Rohrer MD, Prasad HS, Wozney JM, Hall J (2008) Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior maxilla (type IV bone) in non-human primates. J Clin Periodontol 35(11):992–1000. doi:10.1111/j.1600-051X.2008.01322.x PubMedCrossRef

17.

Sykaras N, Triplett RG, Nunn ME, Iacopino AM, Opperman LA (2001) Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants. Clin Oral Implants Res 12(4):339–349PubMedCrossRef

18.

Leknes KN, Yang J, Qahash M, Polimeni G, Susin C, Wikesjo UM (2012) Alveolar ridge augmentation using implants coated with recombinant human growth/differentiation factor-5 (rhGDF-5). radiographic observations. Clin Oral Implants Res 24(11):1185–1191. doi:10.1111/j.1600-0501.2012.02564.x PubMed

19.

Schliephake H (2013) Clinical efficacy of growth factors to enhance tissue repair in oral and maxillofacial reconstruction: a systematic review. Clin Implant Dent Relat Res. doi:10.1111/cid.12114 PubMed

20.

Currey JD (1999) The design of mineralised hard tissues for their mechanical functions. J Exp Biol 202(Pt 23):3285–3294PubMed

21.

Donnelly E, Boskey AL, Baker SP, van der Meulen MC (2010) Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex. J Biomed Mater Res A 92(3):1048–1056. doi:10.1002/jbm.a.32442 PubMedPubMedCentral

22.

Mulder L, Koolstra JH, den Toonder JMJ, van Eijden TMGJ (2007) Intratrabecular distribution of tissues stiffness and mineralization in developing trabecular bone. Bone 41(2):256–265PubMedCrossRef

23.

Mulder L, Koolstra JH, den Toonder JM, van Eijden TM (2008) Relationship between tissue stiffness and degree of mineralization of developing trabecular bone. J Biomed Mater Res A 84(2):508–515PubMedCrossRef

24.

Ruffoni D, Fratzl P, Roschger P, Klaushofer K, Weinkamer R (2007) The bone mineralization density distribution as a fingerprint of the mineralization process. Bone 40(5):1308–1319PubMedCrossRef

25.

Hoffler CE, Guo XE, Zysset PK, Goldstein SA (2005) An application of nanoindentation technique to measure bone tissue lamellae properties. J Biomech Eng 127(7):1046–1053PubMedCrossRef

26.

Rho JY, Tsui TY, Pharr GM (1997) Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation. Biomaterials 18(20):1325–1330PubMedCrossRef

27.

Kim DG, Huja SS, Navalgund A, D'Atri A, Tee B, Reeder S, Ri Lee H (2013b) Effect of estrogen deficiency on regional variation of a viscoelastic tissue property of bone. J Biomech 46(1):110–115. doi:10.1016/j.jbiomech.2012.10.013 PubMedCrossRef

28.

Kim DG, Huja SS, Lee HR, Tee BC, Hueni S (2010) Relationships of viscosity with contact hardness and modulus of bone matrix measured by nanoindentation. J Biomech Eng 132(2):024502. doi:10.1115/1.4000936 PubMedCrossRef

29.

Kim DG, Elias K (2014) Handbook of nanomaterials properties. In: Bhushan B, Luo D, Schricker SR, Sigmund W, Zauscher S (eds) Elastic, viscoelastic, and fracture properties of bone tissue measured by nanoindentation. Springer, Berlin, pp. 1321–1341

30.

Oliver WC, Pharr GM (2004) Measurement of hardness and elastic modulus by instrumented indentation: advances in understanding and refinements to methodology. J Mater Res 19(1):3–20. doi:10.1557/jmr.2004.19.1.3 CrossRef

31.

Fischer-Cripps AC (2004) A simple phenomenological approach to nanoindentation creep. Mat Sci Eng A-Struct 385(1–2):74–82. doi:10.1016/j.msea.2004.04.070 CrossRef

32.

Huja SS, Fernandez SA, Hill KJ, Gulati P (2007) Indentation modulus of the alveolar process in dogs. J Dent Res 86(3):237–241PubMedCrossRef

33.

Rho JY, Pharr GM (1999) Effects of drying on the mechanical properties of bovine femur measured by nanoindentation. J Mater Sci Mater Med 10(8):485–488PubMedCrossRef

34.

Hoffler CE, Moore KE, Kozloff K, Zysset PK, Brown MB, Goldstein SA (2000) Heterogeneity of bone lamellar-level elastic moduli. Bone 26(6):603–609PubMedCrossRef

35.

Lakes RS (1999) Viscoelastic solid. CRC Press, New York, p. 267

36.

Kim DG, Navalgund AR, Tee BC, Noble GJ, Hart RT, Lee HR (2012) Increased variability of bone tissue mineral density resulting from estrogen deficiency influences creep behavior in a rat vertebral body. Bone 51(5):868–875. doi:10.1016/j.bone.2012.08.124 PubMedPubMedCentralCrossRef

37.

Donnelly E, Williams RM, Downs SA, Dickinson ME, Baker SP, van der Meulen MCH (2006) Quasistatic and dynamic nanomechanical properties of cancellous bone tissue relate to collagen content and organization. J Mater Res 21(8):2106–2117. doi:10.1557/Jmr.2006.0259 CrossRef

38.

Isaksson H, Malkiewicz M, Nowak R, Helminen HJ, Jurvelin JS (2010a) Rabbit cortical bone tissue increases its elastic stiffness but becomes less viscoelastic with age. Bone 47(6):1030–1038. doi:10.1016/j.bone.2010.08.015 PubMedCrossRef

39.

Isaksson H, Nagao S, Malkiewicz M, Julkunen P, Nowak R, Jurvelin JS (2010b) Precision of nanoindentation protocols for measurement of viscoelasticity in cortical and trabecular bone. J Biomech 43(12):2410–2417. doi:10.1016/j.jbiomech.2010.04.017 PubMedCrossRef

40.

Poiate IA, de Vasconcellos AB, de Santana RB, Poiate E (2009) Three-dimensional stress distribution in the human periodontal ligament in masticatory, parafunctional, and trauma loads: finite element analysis. J Periodontol 80(11):1859–1867. doi:10.1902/jop.2009.090220 PubMedCrossRef

41.

Ona M, Wakabayashi N (2006) Influence of alveolar support on stress in periodontal structures. J Dent Res 85(12):1087–1091PubMedCrossRef

42.

Iezzi G, Degidi M, Shibli JA, Vantaggiato G, Piattelli A, Perrotti V (2013) Bone response to dental implants after a 3- to 10-year loading period: a histologic and histomorphometric report of four cases. Int J Periodontics Restorative Dent 33(6):755–761. doi:10.11607/prd.1257 CrossRef

43.

Jager IL (2005) A model for the stability and creep of organic materials. J Biomech 38(7):1459–1467PubMedCrossRef

44.

Gupta HS, Krauss S, Kerschnitzki M, Karunaratne A, Dunlop JW, Barber AH, Boesecke P, Funari SS, Fratzl P (2013) Intrafibrillar plasticity through mineral/collagen sliding is the dominant mechanism for the extreme toughness of antler bone. J Mech Behav Biomed Mater 28:366–382. doi:10.1016/j.jmbbm.2013.03.020 PubMedCrossRef

45.

Oyen ML, Ko CC (2007) Examination of local variations in viscous, elastic, and plastic indentation responses in healing bone. J Mater Sci Mater Med 18(4):623–628PubMedCrossRef

46.

Pathak S, Swadener JG, Kalidindi SR, Courtland HW, Jepsen KJ, Goldman HM (2011) Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation. J Mech Behav Biomed Mater 4(1):34–43. doi:10.1016/j.jmbbm.2010.09.002 PubMedCrossRef

Titel: Mechanical properties of bone tissues surrounding dental implant systems with different treatments and healing periods
verfasst von: Do-Gyoon Kim
Hyun-Jung Kwon
Yong-Hoon Jeong
Erin Kosel
Damian J. Lee
Jung-Suk Han
Hye-Lee Kim
Dae-Joon Kim
Publikationsdatum: 02.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 8/2016
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-016-1734-2

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Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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