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Erschienen in: Clinical and Experimental Nephrology 3/2020

06.11.2019 | Original article

Medical evaluation of living kidney donors with nephrolithiasis: a survey of practices in the United States

verfasst von: V. S. Tatapudi, F. Modersitzki, S. Marineci, M. A. Josephson, D. S. Goldfarb

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 3/2020

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Abstract

Background

A scarcity of organs has driven the transplant community to broaden selection criteria for both living and deceased donors. Living donor transplants offer better patient and allograft survival when compared with deceased donor transplants. Many transplant centers now allow complex living donors such as those with nephrolithiasis to undergo nephrectomy.

Methods

We conducted a survey of medical and surgical directors of kidney transplant programs in the United States to shed light on current practices pertaining to medical evaluation of living kidney donors with nephrolithiasis. 353 surveys were e-mailed to medical directors and surgical directors of transplant programs after contacts were obtained from UNOS.

Results

49 completed surveys were returned (13.9%). 77.7% (38/49) of survey participants said their centers will consider living kidney donor candidates with a history of symptomatic kidney stones, 69.4% (34/49) said their centers will consider candidates who are incidentally found to have kidney stones and 10.2% (5/49) said their centers decline all potential donors with nephrolithiasis.

Conclusions

Several programs are still reluctant to allow potential donors with nephrolithiasis to donate. There is an unmet need to develop evidence-based guidelines to optimize outcomes in this population of kidney donors with nephrolithiasis and their recipients.
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Literatur
2.
Zurück zum Zitat El-Zoghby ZM, Stegall MD, Lager DJ, Kremers WK, Amer H, Gloor JM, et al. Identifying specific causes of kidney allograft loss. Am J Transplant. 2009;9(3):527–35.CrossRef El-Zoghby ZM, Stegall MD, Lager DJ, Kremers WK, Amer H, Gloor JM, et al. Identifying specific causes of kidney allograft loss. Am J Transplant. 2009;9(3):527–35.CrossRef
3.
Zurück zum Zitat Evans RW, Manninen DL, Garrison LP Jr, Hart LG, Blagg CR, Gutman RA, et al. The quality of life of patients with end-stage renal disease. N Engl J Med. 1985;312(9):553–9.CrossRef Evans RW, Manninen DL, Garrison LP Jr, Hart LG, Blagg CR, Gutman RA, et al. The quality of life of patients with end-stage renal disease. N Engl J Med. 1985;312(9):553–9.CrossRef
4.
Zurück zum Zitat Schnuelle P, Lorenz D, Trede M, Van Der Woude FJ. Impact of renal cadaveric transplantation on survival in end-stage renal failure: evidence for reduced mortality risk compared with hemodialysis during long-term follow-up. J Am Soc Nephrol. 1998;9(11):2135–41.PubMed Schnuelle P, Lorenz D, Trede M, Van Der Woude FJ. Impact of renal cadaveric transplantation on survival in end-stage renal failure: evidence for reduced mortality risk compared with hemodialysis during long-term follow-up. J Am Soc Nephrol. 1998;9(11):2135–41.PubMed
5.
Zurück zum Zitat Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341(23):1725–30.CrossRef Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341(23):1725–30.CrossRef
6.
Zurück zum Zitat Maggiore U, Cravedi P. The marginal kidney donor. Curr Opin Organ Transplant. 2014;19(4):372–80.CrossRef Maggiore U, Cravedi P. The marginal kidney donor. Curr Opin Organ Transplant. 2014;19(4):372–80.CrossRef
7.
Zurück zum Zitat Reese PP, Caplan AL, Kesselheim AS, Bloom RD. Creating a medical, ethical, and legal framework for complex living kidney donors. Clin J Am Soc Nephrol. 2006;1(6):1148–53.CrossRef Reese PP, Caplan AL, Kesselheim AS, Bloom RD. Creating a medical, ethical, and legal framework for complex living kidney donors. Clin J Am Soc Nephrol. 2006;1(6):1148–53.CrossRef
8.
Zurück zum Zitat Delmonico F. A report of the amsterdam forum on the care of the live kidney donor: data and medical guidelines. Transplantation. 2005;79(6 Suppl):S53–S66.PubMed Delmonico F. A report of the amsterdam forum on the care of the live kidney donor: data and medical guidelines. Transplantation. 2005;79(6 Suppl):S53–S66.PubMed
9.
Zurück zum Zitat Scales CD Jr, Smith AC, Hanley JM, Saigal CS. Prevalence of kidney stones in the United States. Eur Urol. 2012;62(1):160–5.CrossRef Scales CD Jr, Smith AC, Hanley JM, Saigal CS. Prevalence of kidney stones in the United States. Eur Urol. 2012;62(1):160–5.CrossRef
10.
Zurück zum Zitat Strang AM, Lockhart ME, Amling CL, Kolettis PN, Burns JR. Living renal donor allograft lithiasis: a review of stone related morbidity in donors and recipients. J Urol. 2008;179(3):832–6.CrossRef Strang AM, Lockhart ME, Amling CL, Kolettis PN, Burns JR. Living renal donor allograft lithiasis: a review of stone related morbidity in donors and recipients. J Urol. 2008;179(3):832–6.CrossRef
11.
Zurück zum Zitat Kasiske BL, Ravenscraft M, Ramos EL, Gaston RS, Bia MJ, Danovitch GM. The evaluation of living renal transplant donors: clinical practice guidelines. Ad hoc clinical practice guidelines subcommittee of the patient care and education committee of the American Society of Transplant Physicians. J Am Soc Nephrol. 1996;7(11):2288–313.PubMed Kasiske BL, Ravenscraft M, Ramos EL, Gaston RS, Bia MJ, Danovitch GM. The evaluation of living renal transplant donors: clinical practice guidelines. Ad hoc clinical practice guidelines subcommittee of the patient care and education committee of the American Society of Transplant Physicians. J Am Soc Nephrol. 1996;7(11):2288–313.PubMed
12.
Zurück zum Zitat Strang AM, Lockhart ME, Kenney PJ, Amling CL, Urban DA, El-Galley R, et al. Computerized tomographic angiography for renal donor evaluation leads to a higher exclusion rate. J Urol. 2007;177(5):1826–9.CrossRef Strang AM, Lockhart ME, Kenney PJ, Amling CL, Urban DA, El-Galley R, et al. Computerized tomographic angiography for renal donor evaluation leads to a higher exclusion rate. J Urol. 2007;177(5):1826–9.CrossRef
13.
Zurück zum Zitat Lentine KL, Kasiske BL, Levey AS, Adams PL, Alberu J, Bakr MA, et al. KDIGO clinical practice guideline on the evaluation and care of living kidney donors. Transplantation. 2017;101(8S Suppl 1):S1–S109.PubMed Lentine KL, Kasiske BL, Levey AS, Adams PL, Alberu J, Bakr MA, et al. KDIGO clinical practice guideline on the evaluation and care of living kidney donors. Transplantation. 2017;101(8S Suppl 1):S1–S109.PubMed
14.
Zurück zum Zitat Mandelbrot DA, Pavlakis M, Danovitch GM, Johnson SR, Karp SJ, Khwaja K, et al. The medical evaluation of living kidney donors: a survey of US transplant centers. Am J Transplant. 2007;7(10):2333–43.CrossRef Mandelbrot DA, Pavlakis M, Danovitch GM, Johnson SR, Karp SJ, Khwaja K, et al. The medical evaluation of living kidney donors: a survey of US transplant centers. Am J Transplant. 2007;7(10):2333–43.CrossRef
15.
Zurück zum Zitat Ennis J, Kocherginsky M, Schumm LP, Worcester E, Coe FL, Josephson MA. Trends in kidney donation among kidney stone formers: a survey of US transplant centers. Am J Nephrol. 2009;30(1):12–8.CrossRef Ennis J, Kocherginsky M, Schumm LP, Worcester E, Coe FL, Josephson MA. Trends in kidney donation among kidney stone formers: a survey of US transplant centers. Am J Nephrol. 2009;30(1):12–8.CrossRef
16.
Zurück zum Zitat Goldfarb DS. The search for monogenic causes of kidney stones. J Am Soc Nephrol. 2015;26(3):507–10.CrossRef Goldfarb DS. The search for monogenic causes of kidney stones. J Am Soc Nephrol. 2015;26(3):507–10.CrossRef
17.
Zurück zum Zitat Goldfarb DS, Fischer ME, Keich Y, Goldberg J. A twin study of genetic and dietary influences on nephrolithiasis: a report from the Vietnam Era Twin (VET) Registry. Kidney Int. 2005;67(3):1053–61.CrossRef Goldfarb DS, Fischer ME, Keich Y, Goldberg J. A twin study of genetic and dietary influences on nephrolithiasis: a report from the Vietnam Era Twin (VET) Registry. Kidney Int. 2005;67(3):1053–61.CrossRef
18.
Zurück zum Zitat Sayer JA. Progress in understanding the genetics of calcium-containing nephrolithiasis. J Am Soc Nephrol. 2017;28(3):748–59.CrossRef Sayer JA. Progress in understanding the genetics of calcium-containing nephrolithiasis. J Am Soc Nephrol. 2017;28(3):748–59.CrossRef
19.
Zurück zum Zitat Lee YH, Huang WC, Chang LS, Chen MT, Yang YF, Huang JK. The long-term stone recurrence rate and renal function change in unilateral nephrectomy urolithiasis patients. J Urol. 1994;152(5 Pt 1):1386–8.CrossRef Lee YH, Huang WC, Chang LS, Chen MT, Yang YF, Huang JK. The long-term stone recurrence rate and renal function change in unilateral nephrectomy urolithiasis patients. J Urol. 1994;152(5 Pt 1):1386–8.CrossRef
20.
Zurück zum Zitat Trinchieri A, Ostini F, Nespoli R, Rovera F, Montanari E, Zanetti G. A prospective study of recurrence rate and risk factors for recurrence after a first renal stone. J Urol. 1999;162(1):27–30.CrossRef Trinchieri A, Ostini F, Nespoli R, Rovera F, Montanari E, Zanetti G. A prospective study of recurrence rate and risk factors for recurrence after a first renal stone. J Urol. 1999;162(1):27–30.CrossRef
21.
Zurück zum Zitat Olsburgh J, Thomas K, Wong K, Bultitude M, Glass J, Rottenberg G, et al. Incidental renal stones in potential live kidney donors: prevalence, assessment and donation, including role of ex vivo ureteroscopy. BJU Int. 2013;111(5):784–92.CrossRef Olsburgh J, Thomas K, Wong K, Bultitude M, Glass J, Rottenberg G, et al. Incidental renal stones in potential live kidney donors: prevalence, assessment and donation, including role of ex vivo ureteroscopy. BJU Int. 2013;111(5):784–92.CrossRef
Metadaten
Titel
Medical evaluation of living kidney donors with nephrolithiasis: a survey of practices in the United States
verfasst von
V. S. Tatapudi
F. Modersitzki
S. Marineci
M. A. Josephson
D. S. Goldfarb
Publikationsdatum
06.11.2019
Verlag
Springer Singapore
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 3/2020
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-019-01814-6

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