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Erschienen in: Current Fungal Infection Reports 1/2012

01.03.2012 | Current Management of Fungal Infections (L Ostrosky-Zeichner, Section Editor)

Medical Mycology for the Hospital Epidemiologist

verfasst von: Michelle A. Barron

Erschienen in: Current Fungal Infection Reports | Ausgabe 1/2012

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Abstract

Healthcare-associated invasive fungal infections are increasing and are a cause of significant patient morbidity and mortality. Nosocomial infections due to Candida species, followed by Aspergillus species, are the most common causes of these infections in hospitalized patients. Hospital epidemiologists and infection control practitioners must recognize that similar to bacterial pathogens, fungal infections can be the cause of hospital outbreaks, and issues of resistance are increasing. Efforts to best identify patients at risk for developing fungal infections or those at risk of having a resistant organism are ongoing. Better diagnostics and tools to aid prevention are needed in addition to usual infection prevention and control standards.
Literatur
1.
Zurück zum Zitat Eggimann P, Garbino J, Pittet D. Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infect Dis. 2003;3(11):685–702.PubMedCrossRef Eggimann P, Garbino J, Pittet D. Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infect Dis. 2003;3(11):685–702.PubMedCrossRef
2.
Zurück zum Zitat Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis. 2003;36(9):1103–10.PubMedCrossRef Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis. 2003;36(9):1103–10.PubMedCrossRef
3.
Zurück zum Zitat Wisplinghoff H, Bischoff T, Tallent SM, et al. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39(3):309–17.PubMedCrossRef Wisplinghoff H, Bischoff T, Tallent SM, et al. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39(3):309–17.PubMedCrossRef
4.
Zurück zum Zitat • Sydnor ER and Perl TM. Hospital epidemiology and infection control in acute-care settings. Clin Microbiol Rev. 2011; 24(1):141–173. This is a comprehensive review of hospital epidemiology and infection control practices in the acute care setting as well as the changing roles of hospital epidemiologists and infection control practitioners. • Sydnor ER and Perl TM. Hospital epidemiology and infection control in acute-care settings. Clin Microbiol Rev. 2011; 24(1):141–173. This is a comprehensive review of hospital epidemiology and infection control practices in the acute care setting as well as the changing roles of hospital epidemiologists and infection control practitioners.
5.
Zurück zum Zitat • Smith JA, Kauffman CA. Recognition and prevention of nosocomial invasive fungal infections in the intensive care unit. Crit Care Med. 2010; 38(8 Suppl):S380-S387. This article very nicely outlines the epidemiology and prevention strategies associated with nosocomial fungal infections. • Smith JA, Kauffman CA. Recognition and prevention of nosocomial invasive fungal infections in the intensive care unit. Crit Care Med. 2010; 38(8 Suppl):S380-S387. This article very nicely outlines the epidemiology and prevention strategies associated with nosocomial fungal infections.
6.
Zurück zum Zitat Horn DL, Neofytos D, Anaissie EJ, et al. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis. 2009;48(12):1695–703.PubMedCrossRef Horn DL, Neofytos D, Anaissie EJ, et al. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis. 2009;48(12):1695–703.PubMedCrossRef
7.
Zurück zum Zitat Luzzati R, Allegranzi B, Antozzi L, et al. Secular trends in nosocomial candidaemia in non-neutropenic patients in an Italian tertiary hospital. Clin Microbiol Infect. 2005;11(11):908–13.PubMedCrossRef Luzzati R, Allegranzi B, Antozzi L, et al. Secular trends in nosocomial candidaemia in non-neutropenic patients in an Italian tertiary hospital. Clin Microbiol Infect. 2005;11(11):908–13.PubMedCrossRef
8.
Zurück zum Zitat Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20(1):133–63.PubMedCrossRef Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20(1):133–63.PubMedCrossRef
9.
Zurück zum Zitat Ortega M, Marco F, Soriano A, et al. Candida species bloodstream infection: epidemiology and outcome in a single institution from 1991 to 2008. J Hosp Infect. 2011;77(2):157–61.PubMedCrossRef Ortega M, Marco F, Soriano A, et al. Candida species bloodstream infection: epidemiology and outcome in a single institution from 1991 to 2008. J Hosp Infect. 2011;77(2):157–61.PubMedCrossRef
10.
Zurück zum Zitat Hachem R, Hanna H, Kontoyiannis D, Jiang Y, Raad I. The changing epidemiology of invasive candidiasis: Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy. Cancer. 2008;112(11):2493–9.PubMedCrossRef Hachem R, Hanna H, Kontoyiannis D, Jiang Y, Raad I. The changing epidemiology of invasive candidiasis: Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy. Cancer. 2008;112(11):2493–9.PubMedCrossRef
11.
Zurück zum Zitat Pfaller MA, Moet GJ, Messer SA, Jones RN, Castanheira M. Candida bloodstream infections: comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008–2009. Antimicrob Agents Chemother. 2011;55(2):561–6.PubMedCrossRef Pfaller MA, Moet GJ, Messer SA, Jones RN, Castanheira M. Candida bloodstream infections: comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008–2009. Antimicrob Agents Chemother. 2011;55(2):561–6.PubMedCrossRef
12.
Zurück zum Zitat Pfaller MA. Nosocomial candidiasis: emerging species, reservoirs, and modes of transmission. Clin Infect Dis. 1996; 22 Suppl 2S89-S94. Pfaller MA. Nosocomial candidiasis: emerging species, reservoirs, and modes of transmission. Clin Infect Dis. 1996; 22 Suppl 2S89-S94.
13.
Zurück zum Zitat Diekema DJ, Messer SA, Hollis RJ, Wenzel RP, Pfaller MA. An outbreak of Candida parapsilosis prosthetic valve endocarditis. Diagn Microbiol Infect Dis. 1997;29(3):147–53.PubMedCrossRef Diekema DJ, Messer SA, Hollis RJ, Wenzel RP, Pfaller MA. An outbreak of Candida parapsilosis prosthetic valve endocarditis. Diagn Microbiol Infect Dis. 1997;29(3):147–53.PubMedCrossRef
14.
Zurück zum Zitat Masala L, Luzzati R, Maccacaro L, et al. Nosocomial cluster of Candida guillermondii fungemia in surgical patients. Eur J Clin Microbiol Infect Dis. 2003;22(11):686–8.PubMedCrossRef Masala L, Luzzati R, Maccacaro L, et al. Nosocomial cluster of Candida guillermondii fungemia in surgical patients. Eur J Clin Microbiol Infect Dis. 2003;22(11):686–8.PubMedCrossRef
15.
Zurück zum Zitat Hautala T, Ikaheimo I, Husu H, et al. A cluster of Candida krusei infections in a haematological unit. BMC Infect Dis. 2007;7:97. Hautala T, Ikaheimo I, Husu H, et al. A cluster of Candida krusei infections in a haematological unit. BMC Infect Dis. 2007;7:97.
16.
Zurück zum Zitat Vazquez JA, Boikov D, Boikov SG, Dajani AS. Use of electrophoretic karyotyping in the evaluation of Candida infections in a neonatal intensive-care unit. Infect Control Hosp Epidemiol. 1997;18(1):32–7.PubMedCrossRef Vazquez JA, Boikov D, Boikov SG, Dajani AS. Use of electrophoretic karyotyping in the evaluation of Candida infections in a neonatal intensive-care unit. Infect Control Hosp Epidemiol. 1997;18(1):32–7.PubMedCrossRef
17.
Zurück zum Zitat de Repentigny L, Reiss E. Current trends in immunodiagnosis of candidiasis and aspergillosis. Rev Infect Dis. 1984;6(3):301–12.PubMedCrossRef de Repentigny L, Reiss E. Current trends in immunodiagnosis of candidiasis and aspergillosis. Rev Infect Dis. 1984;6(3):301–12.PubMedCrossRef
18.
Zurück zum Zitat Peman J, Zaragoza R. Current diagnostic approaches to invasive candidiasis in critical care settings. Mycoses. 2010;53(5):424–33.PubMedCrossRef Peman J, Zaragoza R. Current diagnostic approaches to invasive candidiasis in critical care settings. Mycoses. 2010;53(5):424–33.PubMedCrossRef
19.
Zurück zum Zitat Pickering JW, Sant HW, Bowles CA, Roberts WL, Woods GL. Evaluation of a (1->3)-beta-D-glucan assay for diagnosis of invasive fungal infections. J Clin Microbiol. 2005;43(12):5957–62.PubMedCrossRef Pickering JW, Sant HW, Bowles CA, Roberts WL, Woods GL. Evaluation of a (1->3)-beta-D-glucan assay for diagnosis of invasive fungal infections. J Clin Microbiol. 2005;43(12):5957–62.PubMedCrossRef
20.
Zurück zum Zitat Walsh TJ, Anaissie EJ, Denning DW, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46(3):327–60.PubMedCrossRef Walsh TJ, Anaissie EJ, Denning DW, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46(3):327–60.PubMedCrossRef
21.
Zurück zum Zitat Mennink-Kersten MA, Warris A, Verweij PE. 1,3-beta-D-glucan in patients receiving intravenous amoxicillin-clavulanic acid. N Engl J Med. 2006;354(26):2834–5.PubMedCrossRef Mennink-Kersten MA, Warris A, Verweij PE. 1,3-beta-D-glucan in patients receiving intravenous amoxicillin-clavulanic acid. N Engl J Med. 2006;354(26):2834–5.PubMedCrossRef
22.
Zurück zum Zitat Odabasi Z, Mattiuzzi G, Estey E, et al. Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin Infect Dis. 2004;39(2):199–205.PubMedCrossRef Odabasi Z, Mattiuzzi G, Estey E, et al. Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin Infect Dis. 2004;39(2):199–205.PubMedCrossRef
23.
Zurück zum Zitat Ostrosky-Zeichner L, Alexander BD, Kett DH, et al. Multicenter clinical evaluation of the (1–>3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humans. Clin Infect Dis. 2005;41(5):654–9.PubMedCrossRef Ostrosky-Zeichner L, Alexander BD, Kett DH, et al. Multicenter clinical evaluation of the (1–>3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humans. Clin Infect Dis. 2005;41(5):654–9.PubMedCrossRef
24.
Zurück zum Zitat Senn L, Robinson JO, Schmidt S, et al. 1,3-Beta-D-glucan antigenemia for early diagnosis of invasive fungal infections in neutropenic patients with acute leukemia. Clin Infect Dis. 2008;46(6):878–85.PubMedCrossRef Senn L, Robinson JO, Schmidt S, et al. 1,3-Beta-D-glucan antigenemia for early diagnosis of invasive fungal infections in neutropenic patients with acute leukemia. Clin Infect Dis. 2008;46(6):878–85.PubMedCrossRef
25.
Zurück zum Zitat • Mohr JF, Sims C, Paetznick V, et al. Prospective survey of (1-->3)-beta-D-glucan and its relationship to invasive candidiasis in the surgical intensive care unit setting. J Clin Microbiol. 2011; 49(1):58–61. This prospective study evaluated the use of BG in the setting of ICU patients at risk for the development of invasive candidiasis (IC). The authors were able to use this test as a diagnostic tool for predicting which patients would later develop IC. • Mohr JF, Sims C, Paetznick V, et al. Prospective survey of (1-->3)-beta-D-glucan and its relationship to invasive candidiasis in the surgical intensive care unit setting. J Clin Microbiol. 2011; 49(1):58–61. This prospective study evaluated the use of BG in the setting of ICU patients at risk for the development of invasive candidiasis (IC). The authors were able to use this test as a diagnostic tool for predicting which patients would later develop IC.
26.
Zurück zum Zitat Burnie JP, Golbang N, Matthews RC. Semiquantitative polymerase chain reaction enzyme immunoassay for diagnosis of disseminated candidiasis. Eur J Clin Microbiol Infect Dis. 1997;16(5):346–50.PubMedCrossRef Burnie JP, Golbang N, Matthews RC. Semiquantitative polymerase chain reaction enzyme immunoassay for diagnosis of disseminated candidiasis. Eur J Clin Microbiol Infect Dis. 1997;16(5):346–50.PubMedCrossRef
27.
Zurück zum Zitat Chryssanthou E, Klingspor L, Tollemar J, et al. PCR and other non-culture methods for diagnosis of invasive Candida infections in allogeneic bone marrow and solid organ transplant recipients. Mycoses. 1999;42(4):239–47.PubMedCrossRef Chryssanthou E, Klingspor L, Tollemar J, et al. PCR and other non-culture methods for diagnosis of invasive Candida infections in allogeneic bone marrow and solid organ transplant recipients. Mycoses. 1999;42(4):239–47.PubMedCrossRef
28.
Zurück zum Zitat Einsele H, Hebart H, Roller G, et al. Detection and identification of fungal pathogens in blood by using molecular probes. J Clin Microbiol. 1997;35(6):1353–60.PubMed Einsele H, Hebart H, Roller G, et al. Detection and identification of fungal pathogens in blood by using molecular probes. J Clin Microbiol. 1997;35(6):1353–60.PubMed
29.
Zurück zum Zitat Florent M, Katsahian S, Vekhoff A, et al. Prospective evaluation of a polymerase chain reaction-ELISA targeted to Aspergillus fumigatus and Aspergillus flavus for the early diagnosis of invasive aspergillosis in patients with hematological malignancies. J Infect Dis. 2006;193(5):741–7.PubMedCrossRef Florent M, Katsahian S, Vekhoff A, et al. Prospective evaluation of a polymerase chain reaction-ELISA targeted to Aspergillus fumigatus and Aspergillus flavus for the early diagnosis of invasive aspergillosis in patients with hematological malignancies. J Infect Dis. 2006;193(5):741–7.PubMedCrossRef
30.
Zurück zum Zitat Kawazu M, Kanda Y, Nannya Y, et al. Prospective comparison of the diagnostic potential of real-time PCR, double-sandwich enzyme-linked immunosorbent assay for galactomannan, and a (1–>3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disorders. J Clin Microbiol. 2004;42(6):2733–41.PubMedCrossRef Kawazu M, Kanda Y, Nannya Y, et al. Prospective comparison of the diagnostic potential of real-time PCR, double-sandwich enzyme-linked immunosorbent assay for galactomannan, and a (1–>3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disorders. J Clin Microbiol. 2004;42(6):2733–41.PubMedCrossRef
31.
Zurück zum Zitat van Burik JA, Myerso D, Schreckhise RW, Bowden RA. Panfungal PCR assay for detection of fungal infection in human blood specimens. J Clin Microbiol. 1998;36(5):1169–75.PubMed van Burik JA, Myerso D, Schreckhise RW, Bowden RA. Panfungal PCR assay for detection of fungal infection in human blood specimens. J Clin Microbiol. 1998;36(5):1169–75.PubMed
32.
Zurück zum Zitat Verweij PE, Meis JF. Microbiological diagnosis of invasive fungal infections in transplant recipients. Transpl Infect Dis. 2000;2(2):80–7.PubMedCrossRef Verweij PE, Meis JF. Microbiological diagnosis of invasive fungal infections in transplant recipients. Transpl Infect Dis. 2000;2(2):80–7.PubMedCrossRef
33.
Zurück zum Zitat Avni T, Leibovici L, Paul M. PCR diagnosis of invasive candidiasis: systematic review and meta-analysis. J Clin Microbiol. 2011;49(2):665–70.PubMedCrossRef Avni T, Leibovici L, Paul M. PCR diagnosis of invasive candidiasis: systematic review and meta-analysis. J Clin Microbiol. 2011;49(2):665–70.PubMedCrossRef
34.
Zurück zum Zitat Cohen Y, Karoubi P, Adrie C, et al. Early prediction of Candida glabrata fungemia in nonneutropenic critically ill patients. Crit Care Med. 2010;38(3):826–30.PubMedCrossRef Cohen Y, Karoubi P, Adrie C, et al. Early prediction of Candida glabrata fungemia in nonneutropenic critically ill patients. Crit Care Med. 2010;38(3):826–30.PubMedCrossRef
35.
Zurück zum Zitat Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R. Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg. 1994;220(6):751–8.PubMedCrossRef Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R. Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg. 1994;220(6):751–8.PubMedCrossRef
36.
Zurück zum Zitat Leon C, Ruiz-Santana S, Saavedra P, et al. A bedside scoring system (“Candida score”) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med. 2006;34(3):730–7.PubMedCrossRef Leon C, Ruiz-Santana S, Saavedra P, et al. A bedside scoring system (“Candida score”) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med. 2006;34(3):730–7.PubMedCrossRef
37.
Zurück zum Zitat Leon C, Ruiz-Santana S, Saavedra P, et al. Usefulness of the “Candida score” for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study. Crit Care Med. 2009;37(5):1624–33.PubMedCrossRef Leon C, Ruiz-Santana S, Saavedra P, et al. Usefulness of the “Candida score” for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study. Crit Care Med. 2009;37(5):1624–33.PubMedCrossRef
38.
Zurück zum Zitat Ostrosky-Zeichner L, Sable C, Sobel J, et al. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis. 2007;26(4):271–6.PubMedCrossRef Ostrosky-Zeichner L, Sable C, Sobel J, et al. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis. 2007;26(4):271–6.PubMedCrossRef
39.
Zurück zum Zitat Ostrosky-Zeichner L, Pappas PG, Shoham S, et al. Improvement of a clinical prediction rule for clinical trials on prophylaxis for invasive candidiasis in the intensive care unit. Mycoses. 2011;54(1):46–51.PubMedCrossRef Ostrosky-Zeichner L, Pappas PG, Shoham S, et al. Improvement of a clinical prediction rule for clinical trials on prophylaxis for invasive candidiasis in the intensive care unit. Mycoses. 2011;54(1):46–51.PubMedCrossRef
40.
Zurück zum Zitat • van de Veerdonk FL, Netea MG, Joosten LA, van der Meer JW, Kullberg BJ. Novel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy. FEMS Microbiol Rev. 2010; 34(6):1063–1075. This is a review of the current immunology of Candida infections and the potential for treatment and prevention strategies using vaccines and immunotherapy. • van de Veerdonk FL, Netea MG, Joosten LA, van der Meer JW, Kullberg BJ. Novel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy. FEMS Microbiol Rev. 2010; 34(6):1063–1075. This is a review of the current immunology of Candida infections and the potential for treatment and prevention strategies using vaccines and immunotherapy.
41.
Zurück zum Zitat Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48(5):503–35.PubMedCrossRef Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48(5):503–35.PubMedCrossRef
42.
Zurück zum Zitat Schuster MG, Edwards Jr JE, Sobel JD, et al. Empirical fluconazole versus placebo for intensive care unit patients: a randomized trial. Ann Intern Med. 2008;149(2):83–90.PubMed Schuster MG, Edwards Jr JE, Sobel JD, et al. Empirical fluconazole versus placebo for intensive care unit patients: a randomized trial. Ann Intern Med. 2008;149(2):83–90.PubMed
43.
Zurück zum Zitat Sable CA, Donowitz GR. Infections in bone marrow transplant recipients. Clin Infect Dis. 1994;18(3):273–81.PubMedCrossRef Sable CA, Donowitz GR. Infections in bone marrow transplant recipients. Clin Infect Dis. 1994;18(3):273–81.PubMedCrossRef
44.
Zurück zum Zitat Singh N, Pursell KJ. Combination therapeutic approaches for the management of invasive aspergillosis in organ transplant recipients. Mycoses. 2008;51(2):99–108.PubMedCrossRef Singh N, Pursell KJ. Combination therapeutic approaches for the management of invasive aspergillosis in organ transplant recipients. Mycoses. 2008;51(2):99–108.PubMedCrossRef
45.
Zurück zum Zitat Morgan J, Wannemuehler KA, Marr KA, et al. Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim results of a prospective multicenter surveillance program. Med Mycol. 2005;43 Suppl 1:S49–58.PubMedCrossRef Morgan J, Wannemuehler KA, Marr KA, et al. Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim results of a prospective multicenter surveillance program. Med Mycol. 2005;43 Suppl 1:S49–58.PubMedCrossRef
46.
Zurück zum Zitat Perfect JR, Cox GM, Lee JY, et al. The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis. Clin Infect Dis. 2001;33(11):1824–33.PubMedCrossRef Perfect JR, Cox GM, Lee JY, et al. The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis. Clin Infect Dis. 2001;33(11):1824–33.PubMedCrossRef
47.
Zurück zum Zitat Kedzierska A, Kochan P, Pietrzyk A, Kedzierska J. Current status of fungal cell wall components in the immunodiagnostics of invasive fungal infections in humans: galactomannan, mannan and (1–>3)-beta-D-glucan antigens. Eur J Clin Microbiol Infect Dis. 2007;26(11):755–66.PubMedCrossRef Kedzierska A, Kochan P, Pietrzyk A, Kedzierska J. Current status of fungal cell wall components in the immunodiagnostics of invasive fungal infections in humans: galactomannan, mannan and (1–>3)-beta-D-glucan antigens. Eur J Clin Microbiol Infect Dis. 2007;26(11):755–66.PubMedCrossRef
48.
Zurück zum Zitat Maertens J, Verhaegen J, Lagrou K, Van Eldere J, Boogaerts M. Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation. Blood. 2001;97(6):1604–10.PubMedCrossRef Maertens J, Verhaegen J, Lagrou K, Van Eldere J, Boogaerts M. Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation. Blood. 2001;97(6):1604–10.PubMedCrossRef
49.
Zurück zum Zitat Maertens J, Van Eldere J, Verhaegen J, et al. Use of circulating galactomannan screening for early diagnosis of invasive aspergillosis in allogeneic stem cell transplant recipients. J Infect Dis. 2002;186(9):1297–306.PubMedCrossRef Maertens J, Van Eldere J, Verhaegen J, et al. Use of circulating galactomannan screening for early diagnosis of invasive aspergillosis in allogeneic stem cell transplant recipients. J Infect Dis. 2002;186(9):1297–306.PubMedCrossRef
50.
Zurück zum Zitat Maertens J, Glasmacher A, Selleslag D, et al. Evaluation of serum sandwich enzyme-linked immunosorbent assay for circulating galactomannan during caspofungin therapy: results from the caspofungin invasive aspergillosis study. Clin Infect Dis. 2005;41(1):e9–e14.PubMedCrossRef Maertens J, Glasmacher A, Selleslag D, et al. Evaluation of serum sandwich enzyme-linked immunosorbent assay for circulating galactomannan during caspofungin therapy: results from the caspofungin invasive aspergillosis study. Clin Infect Dis. 2005;41(1):e9–e14.PubMedCrossRef
51.
Zurück zum Zitat Wheat LJ, Hackett E, Durkin M, et al. Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay. Clin Vaccine Immunol. 2007;14(5):638–40.PubMedCrossRef Wheat LJ, Hackett E, Durkin M, et al. Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay. Clin Vaccine Immunol. 2007;14(5):638–40.PubMedCrossRef
52.
Zurück zum Zitat Viscoli C, Machetti M, Cappellano P, et al. False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam. Clin Infect Dis. 2004;38(6):913–6.PubMedCrossRef Viscoli C, Machetti M, Cappellano P, et al. False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam. Clin Infect Dis. 2004;38(6):913–6.PubMedCrossRef
53.
Zurück zum Zitat Sulahian A, Touratier S, Ribaud P. False positive test for aspergillus antigenemia related to concomitant administration of piperacillin and tazobactam. N Engl J Med. 2003;349(24):2366–7.PubMedCrossRef Sulahian A, Touratier S, Ribaud P. False positive test for aspergillus antigenemia related to concomitant administration of piperacillin and tazobactam. N Engl J Med. 2003;349(24):2366–7.PubMedCrossRef
54.
Zurück zum Zitat Singh N, Obman A, Husain S, et al. Reactivity of platelia Aspergillus galactomannan antigen with piperacillin-tazobactam: clinical implications based on achievable concentrations in serum. Antimicrob Agents Chemother. 2004;48(6):1989–92.PubMedCrossRef Singh N, Obman A, Husain S, et al. Reactivity of platelia Aspergillus galactomannan antigen with piperacillin-tazobactam: clinical implications based on achievable concentrations in serum. Antimicrob Agents Chemother. 2004;48(6):1989–92.PubMedCrossRef
55.
Zurück zum Zitat Adam O, Auperin A, Wilquin F, et al. Treatment with piperacillin-tazobactam and false-positive Aspergillus galactomannan antigen test results for patients with hematological malignancies. Clin Infect Dis. 2004;38(6):917–20.PubMedCrossRef Adam O, Auperin A, Wilquin F, et al. Treatment with piperacillin-tazobactam and false-positive Aspergillus galactomannan antigen test results for patients with hematological malignancies. Clin Infect Dis. 2004;38(6):917–20.PubMedCrossRef
56.
Zurück zum Zitat Miceli MH, Grazziutti ML, Woods G, et al. Strong correlation between serum aspergillus galactomannan index and outcome of aspergillosis in patients with hematological cancer: clinical and research implications. Clin Infect Dis. 2008; 461412–1422. Miceli MH, Grazziutti ML, Woods G, et al. Strong correlation between serum aspergillus galactomannan index and outcome of aspergillosis in patients with hematological cancer: clinical and research implications. Clin Infect Dis. 2008; 461412–1422.
57.
Zurück zum Zitat Maertens J, Theunissen K, Verhoef G, et al. Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study. Clin Infect Dis. 2005;41(9):1242–50.PubMedCrossRef Maertens J, Theunissen K, Verhoef G, et al. Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study. Clin Infect Dis. 2005;41(9):1242–50.PubMedCrossRef
58.
Zurück zum Zitat Clancy CJ, Jaber RA, Leather HL, et al. Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients. J Clin Microbiol. 2007;45(6):1759–65.PubMedCrossRef Clancy CJ, Jaber RA, Leather HL, et al. Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients. J Clin Microbiol. 2007;45(6):1759–65.PubMedCrossRef
59.
Zurück zum Zitat Meersseman W, Lagrou K, Maertens J, et al. Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients. Am J Respir Crit Care Med. 2008;177(1):27–34.PubMedCrossRef Meersseman W, Lagrou K, Maertens J, et al. Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients. Am J Respir Crit Care Med. 2008;177(1):27–34.PubMedCrossRef
60.
Zurück zum Zitat Musher B, Fredricks D, Leisenring W, et al. Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. J Clin Microbiol. 2004;42(12):5517–22.PubMedCrossRef Musher B, Fredricks D, Leisenring W, et al. Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. J Clin Microbiol. 2004;42(12):5517–22.PubMedCrossRef
61.
Zurück zum Zitat Patterson TF. Risk stratification for invasive aspergillosis: early assessment of host susceptibility. Med Mycol. 2009;47 Suppl 1:S255–60.PubMedCrossRef Patterson TF. Risk stratification for invasive aspergillosis: early assessment of host susceptibility. Med Mycol. 2009;47 Suppl 1:S255–60.PubMedCrossRef
62.
Zurück zum Zitat Singh N. Antifungal prophylaxis for solid organ transplant recipients: seeking clarity amidst controversy. Clin Infect Dis. 2000;31(2):545–53.PubMedCrossRef Singh N. Antifungal prophylaxis for solid organ transplant recipients: seeking clarity amidst controversy. Clin Infect Dis. 2000;31(2):545–53.PubMedCrossRef
63.
Zurück zum Zitat Singh N, Paterson DL. Aspergillus infections in transplant recipients. Clin Microbiol Rev. 2005;18(1):44–69.PubMedCrossRef Singh N, Paterson DL. Aspergillus infections in transplant recipients. Clin Microbiol Rev. 2005;18(1):44–69.PubMedCrossRef
64.
Zurück zum Zitat Baddley JW, Andes DR, Marr KA, et al. Factors associated with mortality in transplant patients with invasive aspergillosis. Clin Infect Dis. 2010;50(12):1559–67.PubMedCrossRef Baddley JW, Andes DR, Marr KA, et al. Factors associated with mortality in transplant patients with invasive aspergillosis. Clin Infect Dis. 2010;50(12):1559–67.PubMedCrossRef
66.
Zurück zum Zitat Dykewicz CA, Jaffe HW, Spira J, et al. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000;49(RR-10):1–128. Dykewicz CA, Jaffe HW, Spira J, et al. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000;49(RR-10):1–128.
Metadaten
Titel
Medical Mycology for the Hospital Epidemiologist
verfasst von
Michelle A. Barron
Publikationsdatum
01.03.2012
Verlag
Current Science Inc.
Erschienen in
Current Fungal Infection Reports / Ausgabe 1/2012
Print ISSN: 1936-3761
Elektronische ISSN: 1936-377X
DOI
https://doi.org/10.1007/s12281-011-0077-3

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