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Medical Oncology

Ausgabe 3/2024

Inhalt (18 Artikel)

Original Paper

Up and away with cervical cancer: IL-29 is a promising cytokine for immunotherapy of cervical cancer due to its powerful upregulation of p18, p27, and TRAILR1

Jackie L. Ha, Erin Kaser, Tianyun Guan, Trenton G. Mayberry, Luke A. Smith, Kyle D’mello, Qian Bai, Mark R. Wakefield, Lijun Dong, Yujiang Fang

Original Paper

Regulation of the P53 tumor suppressor gene and the Mcl-2 oncogene expression by an active herbal component delivered through a smart thermo-pH-sensitive PLGA carrier to improve Osteosarcoma treatment

Parinaz Akbari, Mohammad Taebpour, Milad Akhlaghi, Shaimaa Hamid Hasan, Shayesteh Shahriyari, Mahdieh Parsaeian, Bibi Fatemeh Haghirosadat, Abbas Rahdar, Sadanand Pandey

Original Paper

CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway

Jie Xu, Xiangmei Wu, Huifang Zhu, Yinghua Zhu, Kailong Du, Xiaoyan Deng, Changdong Wang

Original Paper

Clinical significance of blocking novel immune checkpoint B7-H4 in urothelial carcinoma of bladder as a potential therapeutic target

David Raja, Aishwarya Singh, Santosh Kurra, Brusabhanu Nayak, Seema Kaushal, Alpana Sharma, Prabhjot Singh

Original Paper

Venetoclax with decitabine or azacitidine in relapsed or refractory acute myeloid leukemia

Ian M. Bouligny, Graeme Murray, Michael Doyel, Tilak Patel, Josh Boron, Valerie Tran, Juhi Gor, Yiwei Hang, Yanal Alnimer, Thuy Ho, Kyle Zacholski, Chad Venn, Nolan A. Wages, Steven Grant, Keri R. Maher

Original Paper

TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma

Yu-Ting Yin, Lu Shi, Chun Wu, Mei-Yin Zhang, Jia-Xin Li, Yu-Feng Zhou, Shuo-Cheng Wang, Hui-Yun Wang, Shi-Juan Mai

Open Access Original Paper

Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS)

Alexander S. Taylor, Rahul Mannan, Liron Pantanowitz, Arul M. Chinnaiyan, Saravana M. Dhanasekaran, Steven Hrycaj, Xuhong Cao, May P. Chan, David Lucas, Xiao-Ming Wang, Rohit Mehra

Original Paper

Estrogen-related receptor alpha (ERRα) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells

Kartik Muduli, Jagannath Pradhan, Monica Prusty, Archana Priyadarshini Samal, K Sony Reddy, Selvakumar Elangovan

Review Article

Pyroptosis in cancer treatment and prevention: the role of natural products and their bioactive compounds

Liyi Wu, Lina Shan, Dengyong Xu, Dengfeng Lin, Bingjun Bai

Review Article

Unlocking the ‘ova’-coming power: immunotherapy’s role in shaping the future of ovarian cancer treatment

Nathan A. Haines, Mia G. Fowler, Benjamin G. Zeh, Carter B. Kriete, Qian Bai, Mark R. Wakefield, Yujiang Fang

Review Article

A therapeutical insight into the correlation between circRNAs and signaling pathways involved in cancer pathogenesis

Raed Obaid Saleh, Sulieman Ibraheem Shelash Al-Hawary, Saade Abdalkareem Jasim, Dmitry Olegovich Bokov, Ahmed Hjazi, Khulood H. Oudaha, Mohammed Jawad Alnajar, Sally Salih Jumaa, Ahmed Alawadi, Ali Alsalamy

Review Article

Advancements in biosensors for cancer detection: revolutionizing diagnostics

Syed Khalid Mustafa, Mohd. Farhan Khan, Mehak Sagheer, Deepak Kumar, Sadanand Pandey

Review Article

Insights into lenvatinib resistance: mechanisms, potential biomarkers, and strategies to enhance sensitivity

Qiang You, Rong Li, Jia Yao, Ying-Cai Zhang, Xin Sui, Cui-Cui Xiao, Jie-Bin Zhang, Jia-Qi Xiao, Hai-Tian Chen, Hua Li, Jian Zhang, Jun Zheng, Yang Yang

Open Access Correction

Correction to: Exploring the advances of single‑cell RNA sequencing in thyroid cancer: a narrative review

Joecelyn Kirani Tan, Wireko Andrew Awuah, Sakshi Roy, Tomas Ferreira, Arjun Ahluwalia, Saibaba Guggilapu, Mahnoor Javed, Muhammad Mikail Athif Zhafir Asyura, Favour Tope Adebusoye, Krishna Ramamoorthy, Emma Paoletti, Toufik Abdul-Rahman, Olha Prykhodko, Denys Ovechkin

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

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