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Medical Oncology

Ausgabe 1/2024

Inhalt (41 Artikel)

Original Paper

Chitosan-encapsulated naringenin promotes ROS mediated through the activation of executioner caspase-3

K. T. Ramya Devi, M. K. Jaganathan, M. R. Ganesh, Karthick Dharshene

Original Paper

In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431)

Pradeep Velusamy, Sridhar Muthusami, Ramakrishnan Arumugam

Original Paper

The evaluation of the anti-cancer effects of Anoectochilus roxburghii on hematological cancers in vitro

Buket Altinok Gunes, Tulin Ozkan, Nurbanu Gonulkirmaz, Asuman Sunguroglu

Open Access Original Paper

Enhanced therapeutic efficacy of doxorubicin/cyclophosphamide in combination with pitavastatin or simvastatin against breast cancer cells

Samar A. Dewidar, Omar Hamdy, Moetaza M. Soliman, Amal M. El Gayar, Mohamed El-Mesery

Original Paper

Upregulation of CELSR1 expression promotes ovarian cancer cell proliferation, migration, and invasion

Jiwei Zuo, Anqi Zheng, Xingyue Wang, Zhicheng Luo, Yueming Chen, Xiaoxiao Cheng, Yuemei Zhao, Xian Zhou, Kai-Fu Tang, Xing Du

Original Paper

Synergistic anti-proliferative and apoptotic effect of NVP-BEZ235 and curcumin on human SH-SY5Y neuroblastoma cells

Fadime Çetin, Sifa Kosba, Hüseyin Abdik, Zeynep Busra Bolat

Original Paper

Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies

Alaa Elmetwalli, Neamat H. Kamosh, Rania El Safty, Amany I. Youssef, Mohammed M. Salama, Khaled M. Abd El-Razek, Tarek El-Sewedy

Original Paper

Short-term pain control after palliative radiotherapy for uncomplicated bone metastases: a prospective cohort study

Sofia Paola Bianchi, Valeria Faccenda, Pietro Pacifico, Gaia Parma, Sara Saufi, Federica Ferrario, Maria Belmonte, Luca Sala, Elena De Ponti, Denis Panizza, Stefano Arcangeli

Original Paper

Development of PD-1 blockade peptide-cell conjugates to enhance cellular therapies for T-cell acute lymphoblastic leukemia

Quanxiao Wang, Hongxing Huang, Peisheng Liang, Lili Wang, Junheng Zheng, Yan Zhang, Hua Wang

Open Access Original Paper

KLF5 promotes esophageal squamous cell cancer through the transcriptional activation of FGFBP1

Fengyun Wang, Ming Luo, Yufeng Cheng

Original Paper

Evaluation of immune density, PD-L1, and CXCR4 expressions in metaplastic breast carcinoma to predict potential immunotherapy benefit

Sidar Bagbudar, Hasan Karanlık, Neslihan Cabioglu, Aysel Bayram, Mustafa Tükenmez, Adnan Aydıner, Ekrem Yavuz, Semen Onder

Original Paper

Data-independent acquisition (DIA) mass spectrometry reveals related proteins involved in the occurrence of early intestinal-type gastric cancer

Liangshun Zhang, Feng Xu, Hongna Lu, Xianwen Dong, Zhiqiang Gao, Qiaosu Zhao, Ting Weng, Hong Li, Hua Ye

Original Paper

Repurposing pantoprazole in combination with systemic therapy in advanced head and neck squamous cell carcinoma: a phase I/II randomized study

Vanita Noronha, Vijay Patil, Nandini Menon, Devanshi Kalra, Ajaykumar Singh, Minit Shah, Supriya Goud, Kunal Jobanputra, Kavita Nawale, Srushti Shah, Oindrila Roy Chowdhury, Vijayalakshmi Mathrudev, Shweta Jogdhankar, Madhu Yadav Singh, Ashish Singh, Supriya Adak, Mayuri Sandesh, R. Arunkumar, Suman Kumar, Abhishek Mahajan, Kumar Prabhash

Original Paper

Association of Wiskott-Aldrich syndrome protein (WASp) in epigenetic regulation of B cell differentiation in non-small-cell lung cancer (NSCLC)

Nikhil Chandnani, Ayush Mandal, Ishika Gupta, Oishi Mukherjee, Sudeshna Rakshit, Geetha Shanmugam, Melvin George, Koustav Sarkar

Original Paper

GNL3L promotes autophagy via regulating AMPK signaling in esophageal cancer cells

Weiting He, Fengyao Sun, Wen Li, Ruihang Du, Siyuan Yan, Changqing Liu

Original Paper

The emerging role of breast cancer derived extracellular vesicles-mediated intercellular communication in ovarian cancer progression and metastasis

Melis Rahime Yıldırım, Oğuz Kaan Kırbaş, Hüseyin Abdik, Fikrettin Şahin, Ezgi Avşar Abdik

Original Paper

Gastrodin inhibits prostate cancer proliferation by targeting canonical Wnt/β-catenin signaling pathway

Ye-Mao Liu, An-Ding Wu, Yun Chen, Teng-Fei Ma, Bi-Zhen Dong, Zhi-Gang She, Mao-Lin Yi, Wei-Ming Mao

Original Paper

USP10 promotes migration and cisplatin resistance in esophageal squamous cell carcinoma cells

Sicong Hou, Tiantian Zhao, Bin Deng, Caimin Li, Wenqian Li, Haifeng Huang, Qinglei Hang

Original Paper

Intestinal epithelial SNAI1 promotes the occurrence of colorectal cancer by enhancing EMT and Wnt/β-catenin signaling

Furong Qing, Junxia Xue, Lina Sui, Qiuxiang Xiao, Tao Xie, Yayun Chen, Junyun Huang, Zhiping Liu

Original Paper

Identification of hub genes to determine drug-disease correlation in breast carcinomas

Chiranjib Bhowmick, Motiur Rahaman, Shatarupa Bhattacharya, Mandrita Mukherjee, Nishant Chakravorty, Pranab Kumar Dutta, Manjunatha Mahadevappa

Original Paper

In silico study of polyphenols as potential inhibitors of MALT1 protein in non-Hodgkin lymphoma

Abas Sezer, Lejla Mahmutović, Betül Akçeşme

Original Paper

Ammonia scavenger and glutamine synthetase inhibitors cocktail in targeting mTOR/β-catenin and MMP-14 for nitrogen homeostasis and liver cancer

Alaa Elmetwalli, Aly Nageh, Amany I. Youssef, Magda Youssef, Mohamed Abd El-Rahman Ahmed, Ahmed E. Noreldin, Tarek El-Sewedy

Original Paper

PERSIAN trial (NCT05717660): an ongoing randomized trial testing androgen deprivation therapy, apalutamide and stereotactic body radiotherapy. An alternative “triplet” for oligometastatic hormone sensitive prostate cancer patients

Giulio Francolini, Angelo Porreca, Gaetano Facchini, Daniele Santini, Alessio Bruni, Nicola Simoni, Marco Trovò, Mattia Falchetto Osti, Giuseppe Fornarini, Michele Sisani, Vanessa Di Cataldo, Beatrice Detti, Pietro Garlatti, Niccolò Bertini, Sergio Serni, Andrea Minervini, Lorenzo Livi

Perspectives in Oncology

What is the optimal (neo)adjuvant strategy of extremity high-risk soft tissue sarcomas (ESTS)?

Saoussane Kharmoum, Jinane Kharmoum, Mariam Chraibi, Sylvie Bonvalot, Jean-yves Blay, Mohammed Shimi

Review Article

Comprehensive genomic profiling for oncological advancements by precision medicine

Maya Pankiw, Christine Brezden-Masley, George S. Charames

Review Article

Emerging treatment approaches for triple-negative breast cancer

Maurizio Capuozzo, Venere Celotto, Mariachiara Santorsola, Antonio Fabozzi, Loris Landi, Francesco Ferrara, Assunta Borzacchiello, Vincenza Granata, Francesco Sabbatino, Giovanni Savarese, Marco Cascella, Francesco Perri, Alessandro Ottaiano

Review Article

Oncolytic viruses improve cancer immunotherapy by reprogramming solid tumor microenvironment

Ling Zhang, Seyed Abbas Pakmehr, Reza Shahhosseini, Maryam Hariri, Azadeh Fakhrioliaei, Farid Karkon Shayan, Wenxue Xiang, Sepideh Karkon Shayan

Review Article

Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy

Rui Fu, Borui Zhao, Min Chen, Xiaolong Fu, Qian Zhang, Yange Cui, Xin Hu, Wei Zhou

Review Article

Estrogen receptor positive breast cancer: contemporary nuances to sequencing therapy

Jenna Schlefman, Christiana Brenin, Trish Millard, Patrick Dillon

Review Article

Epithelial to mesenchymal transition (EMT) in metaplastic breast cancer and phyllodes breast tumors

Ioanna Akrida, Francesk Mulita, Kerasia-Maria Plachouri, Nikolaos Benetatos, Ioannis Maroulis, Helen Papadaki

Review Article

Understanding the charismatic potential of nanotechnology to treat skin carcinoma

Aamravi Sathe, Bhupendra G. Prajapati, Sankha Bhattacharya

Review Article

Recombinant human endostatin as a potential anti-angiogenic agent: therapeutic perspective and current status

J. Anakha, Prakashkumar Dobariya, Shyam Sunder Sharma, Abhay H. Pande

Review Article

Gut microbiota in cancer: insights on microbial metabolites and therapeutic strategies

Yalan Chen, Xibin Wang, Yuwei Ye, Qian Ren

Open Access Review Article

Exploring the advances of single-cell RNA sequencing in thyroid cancer: a narrative review

Joecelyn Kirani Tan, Wireko Andrew Awuah, Sakshi Roy, Tomas Ferreira, Arjun Ahluwalia, Saibaba Guggilapu, Mahnoor Javed, Muhammad Mikail Athif Zhafir Asyura, Favour Tope Adebusoye, Krishna Ramamoorthy, Emma Paoletti, Toufik Abdul-Rahman, Olha Prykhodko, Denys Ovechkin

Review Article

Immune checkpoint inhibitors and cancer immunotherapy by aptamers: an overview

Priyatharcini Kejamurthy, K. T. Ramya Devi

Review Article

COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers

Paul Rodrigues, Harun Bangali, Ahmad Hammoud, Yasser Fakri Mustafa, Hussein Riyadh Abdul Kareem Al-Hetty, Adnan Taan Alkhafaji, Maha Medha Deorari, Muataz Mohammed Al-Taee, Rahman S. Zabibah, Ali Alsalamy

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

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