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Erschienen in: Heart Failure Reviews 1/2008

01.02.2008

Medication adherence in heart failure

verfasst von: Paul J. Hauptman

Erschienen in: Heart Failure Reviews | Ausgabe 1/2008

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Abstract

Non-adherence with medical regimens in heart failure is a significant challenge and serves as a major reason that favorable outcomes associated with various therapies evaluated in clinical trials have not translated to the so-called real-world setting. Non-adherence has complex influences and is clearly associated with poorer outcomes. The approaches that are used or have been proposed to improve drug-taking behavior, such as in-hospital initiation of therapy, simplification of dosing regimens through adoption of combination and long-acting formulations, and improvements in provider–patient communication, are reviewed.
Literatur
1.
Zurück zum Zitat American Heart Association (2007) Heart disease and stroke statistics-2007 update. American Heart Association, Dallas, Tex American Heart Association (2007) Heart disease and stroke statistics-2007 update. American Heart Association, Dallas, Tex
2.
Zurück zum Zitat SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD investigators. N Engl J Med 325:293–302CrossRef SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD investigators. N Engl J Med 325:293–302CrossRef
3.
Zurück zum Zitat Consensus Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure. results of the cooperative north scandinavian enalapril survival study (consensus). The consensus trial study group. N Engl J Med 316:1429–1435CrossRef Consensus Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure. results of the cooperative north scandinavian enalapril survival study (consensus). The consensus trial study group. N Engl J Med 316:1429–1435CrossRef
4.
Zurück zum Zitat Garg R, Yusuf S (1995) Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative group on ace inhibitor trials. JAMA 273:1450–1456PubMedCrossRef Garg R, Yusuf S (1995) Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative group on ace inhibitor trials. JAMA 273:1450–1456PubMedCrossRef
5.
Zurück zum Zitat Jong P, Demers C, Mckelvie RS, Liu PP (2002) Angiotensin receptor blockers in heart failure: meta-analysis of randomized controlled trials. J Am Coll Cardiol 39:463–470PubMedCrossRef Jong P, Demers C, Mckelvie RS, Liu PP (2002) Angiotensin receptor blockers in heart failure: meta-analysis of randomized controlled trials. J Am Coll Cardiol 39:463–470PubMedCrossRef
6.
Zurück zum Zitat Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J et al (2000) Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the metoprolol CR/XL randomized intervention trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group. JAMA 283:1295–1302PubMedCrossRef Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J et al (2000) Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the metoprolol CR/XL randomized intervention trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group. JAMA 283:1295–1302PubMedCrossRef
7.
Zurück zum Zitat CIBIS-II Investigators and Committees (1999) The cardiac insufficiency bisoprolol study II (Cibis-II): a randomised trial. Lancet 353:9–13CrossRef CIBIS-II Investigators and Committees (1999) The cardiac insufficiency bisoprolol study II (Cibis-II): a randomised trial. Lancet 353:9–13CrossRef
8.
Zurück zum Zitat Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM et al (1996) The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. US carvedilol heart failure study group. N Engl J Med 334:1349–1355PubMedCrossRef Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM et al (1996) The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. US carvedilol heart failure study group. N Engl J Med 334:1349–1355PubMedCrossRef
9.
Zurück zum Zitat Packer M, Coats AJ, Fowler MB, Katus HA, Krum H, Mohacsi P et al (2001) Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 344:1651–1658PubMedCrossRef Packer M, Coats AJ, Fowler MB, Katus HA, Krum H, Mohacsi P et al (2001) Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 344:1651–1658PubMedCrossRef
10.
Zurück zum Zitat CAPRICORN Investigators (2001) Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the capricorn randomised trial. Lancet 357:1385–1390CrossRef CAPRICORN Investigators (2001) Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the capricorn randomised trial. Lancet 357:1385–1390CrossRef
11.
Zurück zum Zitat Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. randomized aldactone evaluation study investigators. N Engl J Med 341:709–717PubMedCrossRef Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. randomized aldactone evaluation study investigators. N Engl J Med 341:709–717PubMedCrossRef
12.
Zurück zum Zitat Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B et al (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348:1309–1321PubMedCrossRef Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B et al (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348:1309–1321PubMedCrossRef
13.
Zurück zum Zitat Taylor AL, Ziesche S, Yancy C, Carson P, D’Agostino R Jr, Ferdinand K et al (2004) Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 351:2049–2057PubMedCrossRef Taylor AL, Ziesche S, Yancy C, Carson P, D’Agostino R Jr, Ferdinand K et al (2004) Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 351:2049–2057PubMedCrossRef
14.
Zurück zum Zitat Krumholz HM, Baker DW, Ashton CM, Dunbar SB, Friesinger GC, Havranek EP et al (2000) Evaluating quality of care for patients with heart failure. Circulation 101:E122–E140PubMed Krumholz HM, Baker DW, Ashton CM, Dunbar SB, Friesinger GC, Havranek EP et al (2000) Evaluating quality of care for patients with heart failure. Circulation 101:E122–E140PubMed
15.
Zurück zum Zitat Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF et al (2003) Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. Am Heart J 146:250–257PubMedCrossRef Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF et al (2003) Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. Am Heart J 146:250–257PubMedCrossRef
16.
Zurück zum Zitat Yancy CW (2004) Heart failure therapy in special populations: the same or different? Rev Cardiovasc Med 5(Suppl 1):S28–S35PubMed Yancy CW (2004) Heart failure therapy in special populations: the same or different? Rev Cardiovasc Med 5(Suppl 1):S28–S35PubMed
17.
Zurück zum Zitat Galvao M, Kalman J, Demarco T, Fonarow GC, Galvin C, Ghali JK et al (2006) Gender differences in in-hospital management and outcomes in patients with decompensated heart failure: analysis from the acute decompensated heart failure national registry (ADHERE). J Card Fail 12:100–107PubMedCrossRef Galvao M, Kalman J, Demarco T, Fonarow GC, Galvin C, Ghali JK et al (2006) Gender differences in in-hospital management and outcomes in patients with decompensated heart failure: analysis from the acute decompensated heart failure national registry (ADHERE). J Card Fail 12:100–107PubMedCrossRef
18.
Zurück zum Zitat Butler J, Arbogast PG, Daugherty J, Jain Mk, Ray WA, Griffin MR (2004) Outpatient utilization of angiotensin-converting enzyme inhibitors among heart failure patients after hospital discharge. J Am Coll Cardiol 43:2036–2043PubMedCrossRef Butler J, Arbogast PG, Daugherty J, Jain Mk, Ray WA, Griffin MR (2004) Outpatient utilization of angiotensin-converting enzyme inhibitors among heart failure patients after hospital discharge. J Am Coll Cardiol 43:2036–2043PubMedCrossRef
19.
Zurück zum Zitat Fonarow GC, Abraham WT, Albert NM, Gattis WA, Gheorghiade M, Greenberg B et al (2004) Organized program to initiate lifesaving treatment in hospitalized patients with heart failure (OPTIMIZE-HF): rationale and design. Am Heart J 148:43–51PubMedCrossRef Fonarow GC, Abraham WT, Albert NM, Gattis WA, Gheorghiade M, Greenberg B et al (2004) Organized program to initiate lifesaving treatment in hospitalized patients with heart failure (OPTIMIZE-HF): rationale and design. Am Heart J 148:43–51PubMedCrossRef
20.
21.
Zurück zum Zitat Massie BM (2005) Aspirin use in chronic heart failure: what should we recommend to the practitioner? J Am Coll Cardiol 46:963–966PubMedCrossRef Massie BM (2005) Aspirin use in chronic heart failure: what should we recommend to the practitioner? J Am Coll Cardiol 46:963–966PubMedCrossRef
22.
Zurück zum Zitat Amabile CM, Spencer Ap (2004) Keeping your patient with heart failure safe: a review of potentially dangerous medications. Arch Intern Med 164:709–720PubMedCrossRef Amabile CM, Spencer Ap (2004) Keeping your patient with heart failure safe: a review of potentially dangerous medications. Arch Intern Med 164:709–720PubMedCrossRef
23.
Zurück zum Zitat Guazzi M, Brambilla R, Reina G, Tumminello G, Guazzi MD (2003) Aspirin-angiotensin-converting enzyme inhibitor coadministration and mortality in patients with heart failure: a dose-related adverse effect of aspirin. Arch Intern Med 163:1574–1579PubMedCrossRef Guazzi M, Brambilla R, Reina G, Tumminello G, Guazzi MD (2003) Aspirin-angiotensin-converting enzyme inhibitor coadministration and mortality in patients with heart failure: a dose-related adverse effect of aspirin. Arch Intern Med 163:1574–1579PubMedCrossRef
24.
Zurück zum Zitat Slordal L, Spigset O (2006) Heart failure induced by non-cardiac drugs. Drug Saf 29:567–586PubMedCrossRef Slordal L, Spigset O (2006) Heart failure induced by non-cardiac drugs. Drug Saf 29:567–586PubMedCrossRef
25.
Zurück zum Zitat Leventhal MJ, Riegel B, Carlson B, De GS (2005) Negotiating compliance in heart failure: remaining issues and questions. Eur J Cardiovasc Nurs 4:298–307PubMedCrossRef Leventhal MJ, Riegel B, Carlson B, De GS (2005) Negotiating compliance in heart failure: remaining issues and questions. Eur J Cardiovasc Nurs 4:298–307PubMedCrossRef
26.
Zurück zum Zitat Skrepnek GH, Abarca J, Malone DC, Armstrong EP, Shirazi FM, Woosley RL (2005) Incremental effects of concurrent pharmacotherapeutic regimens for heart failure on hospitalizations and costs. Ann Pharmacother 39:1785–1791PubMedCrossRef Skrepnek GH, Abarca J, Malone DC, Armstrong EP, Shirazi FM, Woosley RL (2005) Incremental effects of concurrent pharmacotherapeutic regimens for heart failure on hospitalizations and costs. Ann Pharmacother 39:1785–1791PubMedCrossRef
27.
Zurück zum Zitat Hope CJ, Wu J, Tu W, Young J, Murray MD (2004) Association of medication adherence, knowledge, and skills with emergency department visits by adults 50 years or older with congestive heart failure. Am J Health Syst Pharm 61:2043–2049PubMed Hope CJ, Wu J, Tu W, Young J, Murray MD (2004) Association of medication adherence, knowledge, and skills with emergency department visits by adults 50 years or older with congestive heart failure. Am J Health Syst Pharm 61:2043–2049PubMed
28.
Zurück zum Zitat Tilson HH (2004) Adherence or compliance? Changes in terminology. Ann Pharmacother 38:161–162PubMedCrossRef Tilson HH (2004) Adherence or compliance? Changes in terminology. Ann Pharmacother 38:161–162PubMedCrossRef
29.
30.
Zurück zum Zitat Stromberg A (2005) The crucial role of patient education in heart failure. Eur J Heart Fail 7:363–369PubMedCrossRef Stromberg A (2005) The crucial role of patient education in heart failure. Eur J Heart Fail 7:363–369PubMedCrossRef
31.
Zurück zum Zitat Van Der Wal MH, Jaarsma T, Moser DK, Veeger Van NJ, Gilst Van WH, Veldhuisen DJ (2006) Compliance in heart failure patients: the importance of knowledge and beliefs. Eur Heart J 27:434–440CrossRef Van Der Wal MH, Jaarsma T, Moser DK, Veeger Van NJ, Gilst Van WH, Veldhuisen DJ (2006) Compliance in heart failure patients: the importance of knowledge and beliefs. Eur Heart J 27:434–440CrossRef
32.
Zurück zum Zitat Caetano PA, Lam JM, Morgan SG (2006) Toward a standard definition and measurement of persistence with drug therapy: examples from research on statin and antihypertensive utilization. Clin Ther 28:1411–1424, Discussion 1410PubMedCrossRef Caetano PA, Lam JM, Morgan SG (2006) Toward a standard definition and measurement of persistence with drug therapy: examples from research on statin and antihypertensive utilization. Clin Ther 28:1411–1424, Discussion 1410PubMedCrossRef
33.
Zurück zum Zitat Chui MA, Deer M, Bennett SJ, Tu W, Oury S, Brater DC et al (2003) Association between adherence to diuretic therapy and health care utilization in patients with heart failure. Pharmacotherapy 23:326–332PubMedCrossRef Chui MA, Deer M, Bennett SJ, Tu W, Oury S, Brater DC et al (2003) Association between adherence to diuretic therapy and health care utilization in patients with heart failure. Pharmacotherapy 23:326–332PubMedCrossRef
34.
Zurück zum Zitat Claxton AJ, Cramer J, Pierce C (2001) A systematic review of the associations between dose regimens and medication compliance. Clin Ther 23:1296–1310PubMedCrossRef Claxton AJ, Cramer J, Pierce C (2001) A systematic review of the associations between dose regimens and medication compliance. Clin Ther 23:1296–1310PubMedCrossRef
35.
Zurück zum Zitat Wetzels GE, Nelemans P, Schouten JS, Prins MH (2004) Facts and fiction of poor compliance as a cause of inadequate blood pressure control: a systematic review. J Hypertens 22:1849–1855PubMedCrossRef Wetzels GE, Nelemans P, Schouten JS, Prins MH (2004) Facts and fiction of poor compliance as a cause of inadequate blood pressure control: a systematic review. J Hypertens 22:1849–1855PubMedCrossRef
36.
Zurück zum Zitat Tu W, Morris AB, Li J, Wu J, Young J, Brater DC et al (2005) Association between adherence measurements of metoprolol and health care utilization in older patients with heart failure. Clin Pharmacol Ther 77:189–201PubMedCrossRef Tu W, Morris AB, Li J, Wu J, Young J, Brater DC et al (2005) Association between adherence measurements of metoprolol and health care utilization in older patients with heart failure. Clin Pharmacol Ther 77:189–201PubMedCrossRef
37.
Zurück zum Zitat Waeber B (2004) What has been learned from electronic monitoring of compliance with antihypertensive medications? J Hypertens 22:1857–1858PubMedCrossRef Waeber B (2004) What has been learned from electronic monitoring of compliance with antihypertensive medications? J Hypertens 22:1857–1858PubMedCrossRef
38.
Zurück zum Zitat Andrejak M, Genes N, Vaur L, Poncelet P, Clerson P, Carre A (2000) Electronic pill-boxes in the evaluation of antihypertensive treatment compliance: comparison of once daily versus twice daily regimen. Am J Hypertens 13:184–190PubMedCrossRef Andrejak M, Genes N, Vaur L, Poncelet P, Clerson P, Carre A (2000) Electronic pill-boxes in the evaluation of antihypertensive treatment compliance: comparison of once daily versus twice daily regimen. Am J Hypertens 13:184–190PubMedCrossRef
39.
Zurück zum Zitat Straka RJ, Fish JT, Benson SR, Suh JT (1997) Patient self-reporting of compliance does not correspond with electronic monitoring: an evaluation using isosorbide dinitrate as a model drug. Pharmacotherapy 17:126–132PubMed Straka RJ, Fish JT, Benson SR, Suh JT (1997) Patient self-reporting of compliance does not correspond with electronic monitoring: an evaluation using isosorbide dinitrate as a model drug. Pharmacotherapy 17:126–132PubMed
40.
Zurück zum Zitat Kardas P (2004) Comparison of once daily versus twice daily oral nitrates in stable angina pectoris. Am J Cardiol 94:213–216PubMedCrossRef Kardas P (2004) Comparison of once daily versus twice daily oral nitrates in stable angina pectoris. Am J Cardiol 94:213–216PubMedCrossRef
41.
Zurück zum Zitat Dunbar-Jacob J, Bohachick P, Mortimer MK, Sereika SM, Foley SM (2003) Medication adherence in persons with cardiovascular disease. J Cardiovasc Nurs 18:209–218PubMed Dunbar-Jacob J, Bohachick P, Mortimer MK, Sereika SM, Foley SM (2003) Medication adherence in persons with cardiovascular disease. J Cardiovasc Nurs 18:209–218PubMed
42.
Zurück zum Zitat Kramer JM, Hammill B, Anstrom KJ, Fetterolf D, Snyder R, Charde JP et al (2006) National evaluation of adherence to beta-blocker therapy for 1 year after acute myocardial infarction in patients with commercial health insurance. Am Heart J 152:454–458PubMedCrossRef Kramer JM, Hammill B, Anstrom KJ, Fetterolf D, Snyder R, Charde JP et al (2006) National evaluation of adherence to beta-blocker therapy for 1 year after acute myocardial infarction in patients with commercial health insurance. Am Heart J 152:454–458PubMedCrossRef
43.
Zurück zum Zitat Urquhart J (2004) Pharmionics: research on what patients do with prescription drugs. Pharmacoepidemiol Drug Saf 13:587–590PubMedCrossRef Urquhart J (2004) Pharmionics: research on what patients do with prescription drugs. Pharmacoepidemiol Drug Saf 13:587–590PubMedCrossRef
44.
Zurück zum Zitat Ho PM, Spertus JA, Masoudi FA, Reid KJ, Peterson ED, Magid DJ et al (2006) Impact of medication therapy discontinuation on mortality after myocardial infarction. Arch Intern Med 166:1842–1847PubMedCrossRef Ho PM, Spertus JA, Masoudi FA, Reid KJ, Peterson ED, Magid DJ et al (2006) Impact of medication therapy discontinuation on mortality after myocardial infarction. Arch Intern Med 166:1842–1847PubMedCrossRef
45.
Zurück zum Zitat Masoudi FA, Baillie CA, Wang Y, Bradford WD, Steiner JF, Havranek EP et al (2005) The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998–2001. Arch Intern Med 165:2069–2076PubMedCrossRef Masoudi FA, Baillie CA, Wang Y, Bradford WD, Steiner JF, Havranek EP et al (2005) The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998–2001. Arch Intern Med 165:2069–2076PubMedCrossRef
46.
Zurück zum Zitat Soumerai SB, Pierre-Jacques M, Zhang F, Ross-Degnan D, Adams AS, Gurwitz J et al (2006) Cost-related medication nonadherence among elderly and disabled medicare beneficiaries: a national survey 1 year before the medicare drug benefit. Arch Intern Med 166:1829–1835PubMedCrossRef Soumerai SB, Pierre-Jacques M, Zhang F, Ross-Degnan D, Adams AS, Gurwitz J et al (2006) Cost-related medication nonadherence among elderly and disabled medicare beneficiaries: a national survey 1 year before the medicare drug benefit. Arch Intern Med 166:1829–1835PubMedCrossRef
47.
Zurück zum Zitat Lee DS, Tu JV, Juurlink DN, Alter DA, Ko DT, Austin PC et al (2005) Risk-treatment mismatch in the pharmacotherapy of heart failure. JAMA 294:1240–1247PubMedCrossRef Lee DS, Tu JV, Juurlink DN, Alter DA, Ko DT, Austin PC et al (2005) Risk-treatment mismatch in the pharmacotherapy of heart failure. JAMA 294:1240–1247PubMedCrossRef
48.
Zurück zum Zitat Spencer FA, Meyer TE, Gore JM, Goldberg RJ (2002) Heterogeneity in the management and outcomes of patients with acute myocardial infarction complicated by heart failure: the national registry of myocardial infarction. Circulation 105:2605–2610PubMedCrossRef Spencer FA, Meyer TE, Gore JM, Goldberg RJ (2002) Heterogeneity in the management and outcomes of patients with acute myocardial infarction complicated by heart failure: the national registry of myocardial infarction. Circulation 105:2605–2610PubMedCrossRef
49.
Zurück zum Zitat Gattis WA, O’Connor CM, Gallup DS, Hasselblad V, Gheorghiade M (2004) Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the initiation management predischarge: process for assessment of carvedilol therapy in heart failure (IMPACT-HF) trial. J Am Coll Cardiol 43:1534–1541PubMedCrossRef Gattis WA, O’Connor CM, Gallup DS, Hasselblad V, Gheorghiade M (2004) Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the initiation management predischarge: process for assessment of carvedilol therapy in heart failure (IMPACT-HF) trial. J Am Coll Cardiol 43:1534–1541PubMedCrossRef
50.
Zurück zum Zitat Lee JK, Grace KA, Taylor AJ (2006) Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA 296:2563–2571PubMedCrossRef Lee JK, Grace KA, Taylor AJ (2006) Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA 296:2563–2571PubMedCrossRef
51.
Zurück zum Zitat Phillips CO, Singa RM, Rubin HR, Jaarsma T (2005) Complexity of program and clinical outcomes of heart failure disease management incorporating specialist nurse-led heart failure clinics. A meta-regression analysis. Eur J Heart Fail 7:333–341PubMedCrossRef Phillips CO, Singa RM, Rubin HR, Jaarsma T (2005) Complexity of program and clinical outcomes of heart failure disease management incorporating specialist nurse-led heart failure clinics. A meta-regression analysis. Eur J Heart Fail 7:333–341PubMedCrossRef
52.
Zurück zum Zitat Anderson C, Deepak BV Amoateng-Adjepong Y, Zarich S (2005) Benefits of comprehensive inpatient education and discharge planning combined with outpatient support in elderly patients with congestive heart failure. Congest Heart Fail 11:315–321PubMedCrossRef Anderson C, Deepak BV Amoateng-Adjepong Y, Zarich S (2005) Benefits of comprehensive inpatient education and discharge planning combined with outpatient support in elderly patients with congestive heart failure. Congest Heart Fail 11:315–321PubMedCrossRef
53.
Zurück zum Zitat Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM (1995) A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 333:1190–1195PubMedCrossRef Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM (1995) A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 333:1190–1195PubMedCrossRef
54.
Zurück zum Zitat Spertus JA, Dewhurst T, Dougherty CM, Nichol P (2001) Testing the effectiveness of converting patients to long-acting antianginal medications: the quality of life in angina research trial (QUART). Am Heart J 141:550–558PubMedCrossRef Spertus JA, Dewhurst T, Dougherty CM, Nichol P (2001) Testing the effectiveness of converting patients to long-acting antianginal medications: the quality of life in angina research trial (QUART). Am Heart J 141:550–558PubMedCrossRef
55.
Zurück zum Zitat Combination pharmacotherapy and public health research working group (2005) Combination pharmacotherapy for cardiovascular disease. Ann Intern Med 143:593–599 Combination pharmacotherapy and public health research working group (2005) Combination pharmacotherapy for cardiovascular disease. Ann Intern Med 143:593–599
56.
Zurück zum Zitat Bakris GL, Fonseca V, Katholi RE, Mcgill JB, Messerli FH, Phillips RA et al (2004) Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial. JAMA 292:2227–2236PubMedCrossRef Bakris GL, Fonseca V, Katholi RE, Mcgill JB, Messerli FH, Phillips RA et al (2004) Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial. JAMA 292:2227–2236PubMedCrossRef
57.
Zurück zum Zitat Roccaforte R, Demers C, Baldassarre F, Teo KK, Yusuf S (2005) Effectiveness of comprehensive disease management programmes in improving clinical outcomes in heart failure patients. A meta-analysis. Eur J Heart Fail 7:1133–1144PubMedCrossRef Roccaforte R, Demers C, Baldassarre F, Teo KK, Yusuf S (2005) Effectiveness of comprehensive disease management programmes in improving clinical outcomes in heart failure patients. A meta-analysis. Eur J Heart Fail 7:1133–1144PubMedCrossRef
58.
Zurück zum Zitat Tarn DM, Heritage J, Paterniti DA, Hays RD, Kravitz RL, Wenger NS (2006) Physician communication when prescribing new medications. Arch Intern Med 166:1855–1862PubMedCrossRef Tarn DM, Heritage J, Paterniti DA, Hays RD, Kravitz RL, Wenger NS (2006) Physician communication when prescribing new medications. Arch Intern Med 166:1855–1862PubMedCrossRef
59.
Zurück zum Zitat Bokhour BG, Berlowitz DR, Long JA, Kressin NR (2006) How do providers assess antihypertensive medication adherence in medical encounters? J Gen Intern Med 21:577–583PubMedCrossRef Bokhour BG, Berlowitz DR, Long JA, Kressin NR (2006) How do providers assess antihypertensive medication adherence in medical encounters? J Gen Intern Med 21:577–583PubMedCrossRef
60.
Zurück zum Zitat Kosiborod M, Lichtman JH, Heidenreich PA, Normand SL, Wang Y, Brass LM et al (2006) National trends in outcomes among elderly patients with heart failure. Am J Med 119(7):616–617PubMedCrossRef Kosiborod M, Lichtman JH, Heidenreich PA, Normand SL, Wang Y, Brass LM et al (2006) National trends in outcomes among elderly patients with heart failure. Am J Med 119(7):616–617PubMedCrossRef
61.
Zurück zum Zitat Massie BM, Shah NB (1997) Evolving trends in the epidemiologic factors of heart failure: rationale for preventive strategies and comprehensive disease management. Am Heart J 133:703–712PubMedCrossRef Massie BM, Shah NB (1997) Evolving trends in the epidemiologic factors of heart failure: rationale for preventive strategies and comprehensive disease management. Am Heart J 133:703–712PubMedCrossRef
62.
Zurück zum Zitat Vinson JM, Rich MW, Sperry JC, Shah AS, McNamara T (1990) Early readmission of elderly patients with congestive heart failure. J Am Geriatr Soc 38:1290–1295PubMed Vinson JM, Rich MW, Sperry JC, Shah AS, McNamara T (1990) Early readmission of elderly patients with congestive heart failure. J Am Geriatr Soc 38:1290–1295PubMed
63.
Zurück zum Zitat Kravitz RL, Hays RD, Sherbourne CD, Dimatteo MR, Rogers WH, Ordway L et al (1993) Recall of recommendations and adherence to advice among patients with chronic medical conditions. Arch Intern Med 153:1869–1878PubMedCrossRef Kravitz RL, Hays RD, Sherbourne CD, Dimatteo MR, Rogers WH, Ordway L et al (1993) Recall of recommendations and adherence to advice among patients with chronic medical conditions. Arch Intern Med 153:1869–1878PubMedCrossRef
64.
Zurück zum Zitat Abraham WT, Hayes DL (2003) Cardiac resynchronization therapy for heart failure. Circulation 108:2596–2603PubMedCrossRef Abraham WT, Hayes DL (2003) Cardiac resynchronization therapy for heart failure. Circulation 108:2596–2603PubMedCrossRef
65.
Zurück zum Zitat Wolbrette DL, Naccarelli GV (2001) Management of implantable cardioverter defibrillator patients: role of predischarge electrophysiologic testing and proper patient instruction before hospital discharge. Curr Opin Cardiol 16:72–75PubMedCrossRef Wolbrette DL, Naccarelli GV (2001) Management of implantable cardioverter defibrillator patients: role of predischarge electrophysiologic testing and proper patient instruction before hospital discharge. Curr Opin Cardiol 16:72–75PubMedCrossRef
66.
Zurück zum Zitat Gronefeld G, Kleine P, Israel CW, Hohnloser SH (2002) “Twiddler syndrome” in a subpectorally implanted cardioverter defibrillator. J Cardiovasc Electrophysiol 13:94PubMedCrossRef Gronefeld G, Kleine P, Israel CW, Hohnloser SH (2002) “Twiddler syndrome” in a subpectorally implanted cardioverter defibrillator. J Cardiovasc Electrophysiol 13:94PubMedCrossRef
67.
Zurück zum Zitat Kramer JM, Fetterolf D, Charde JP, Snyder R, Checkman D, Delong E et al (2004) National evaluation of long-term adherence to beta-blocker therapy after acute myocardial infarction in patients with commercial health insurance. presented at: American College of Cardiology (2004) annual meeting; March 9, 2004; New Orleans, La. J Am Coll Cardiol 43:415A–416ACrossRef Kramer JM, Fetterolf D, Charde JP, Snyder R, Checkman D, Delong E et al (2004) National evaluation of long-term adherence to beta-blocker therapy after acute myocardial infarction in patients with commercial health insurance. presented at: American College of Cardiology (2004) annual meeting; March 9, 2004; New Orleans, La. J Am Coll Cardiol 43:415A–416ACrossRef
68.
Zurück zum Zitat Eagle KA, Kline-Rogers E, Goodman SG, Gurfinkel EP, Avezum A, Flather MD et al (2004) Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational study. Am J Med 117:73–81PubMedCrossRef Eagle KA, Kline-Rogers E, Goodman SG, Gurfinkel EP, Avezum A, Flather MD et al (2004) Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational study. Am J Med 117:73–81PubMedCrossRef
69.
Zurück zum Zitat Jackevicius CA, Mamdani M, Tu JV (2002) Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA 288:462–467PubMedCrossRef Jackevicius CA, Mamdani M, Tu JV (2002) Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA 288:462–467PubMedCrossRef
70.
Zurück zum Zitat Chapman RH, Benner JS, Petrilla AA, Tierce JC, Collins SR, Battleman DS et al (2005) Predictors of adherence with antihypertensive and lipid-lowering therapy. Arch Intern Med 165:1147–1152PubMedCrossRef Chapman RH, Benner JS, Petrilla AA, Tierce JC, Collins SR, Battleman DS et al (2005) Predictors of adherence with antihypertensive and lipid-lowering therapy. Arch Intern Med 165:1147–1152PubMedCrossRef
71.
Zurück zum Zitat Mena-Martin FJ, Martin-Escudero JC, Simal-Blanco F, Carretero-Ares JL, Arzua-Mouronte D, Herreros-Fernandez V (2003) Health-related quality of life of subjects with known and unknown hypertension: results from the population-based hortega study. J Hypertens 21:1283–1289PubMedCrossRef Mena-Martin FJ, Martin-Escudero JC, Simal-Blanco F, Carretero-Ares JL, Arzua-Mouronte D, Herreros-Fernandez V (2003) Health-related quality of life of subjects with known and unknown hypertension: results from the population-based hortega study. J Hypertens 21:1283–1289PubMedCrossRef
72.
Zurück zum Zitat Mallion JM, Baguet JP, Siche JP, Tremel F, De GR (1998) Compliance, electronic monitoring and antihypertensive drugs. J Hypertens Suppl 16(1):S75–S79PubMed Mallion JM, Baguet JP, Siche JP, Tremel F, De GR (1998) Compliance, electronic monitoring and antihypertensive drugs. J Hypertens Suppl 16(1):S75–S79PubMed
73.
Zurück zum Zitat Hajjar I, Kotchen TA (2003) Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000. JAMA 290:199–206PubMedCrossRef Hajjar I, Kotchen TA (2003) Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000. JAMA 290:199–206PubMedCrossRef
74.
Zurück zum Zitat Cheng JW, Kalis MM, Feifer S (2001) Patient-reported adherence to guidelines of the Sixth Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Pharmacotherapy 21:828–841PubMedCrossRef Cheng JW, Kalis MM, Feifer S (2001) Patient-reported adherence to guidelines of the Sixth Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Pharmacotherapy 21:828–841PubMedCrossRef
75.
Zurück zum Zitat Rogers WJ, Johnstone DE, Yusuf S, Weiner DH, Gallagher P, Bittner VA, Ahn S, Schron E, Shumaker SA, Sheffield LT (1994) Quality of life among 5,025 patients with left ventricular dysfunction randomized between placebo and enalapril: the studies of left ventricular dysfunction. J Am Coll Cardiol 23:393–400PubMedCrossRef Rogers WJ, Johnstone DE, Yusuf S, Weiner DH, Gallagher P, Bittner VA, Ahn S, Schron E, Shumaker SA, Sheffield LT (1994) Quality of life among 5,025 patients with left ventricular dysfunction randomized between placebo and enalapril: the studies of left ventricular dysfunction. J Am Coll Cardiol 23:393–400PubMedCrossRef
76.
Zurück zum Zitat Bohachick P, Burke LE, Sereika S, Murali S, Dunbar-Jacob J (2002) Adherence to angiotensin-converting enzyme inhibitor therapy for heart failure. Prog Cardiovasc Nurs 17:160–166PubMedCrossRef Bohachick P, Burke LE, Sereika S, Murali S, Dunbar-Jacob J (2002) Adherence to angiotensin-converting enzyme inhibitor therapy for heart failure. Prog Cardiovasc Nurs 17:160–166PubMedCrossRef
77.
Zurück zum Zitat Horwitz RI, Viscoli CM, Berkman L, Donaldson RM, Horwitz SM, Murray CJ et al (1990) Treatment adherence and risk of death after a myocardial infarction. Lancet 336:542–545PubMedCrossRef Horwitz RI, Viscoli CM, Berkman L, Donaldson RM, Horwitz SM, Murray CJ et al (1990) Treatment adherence and risk of death after a myocardial infarction. Lancet 336:542–545PubMedCrossRef
78.
Zurück zum Zitat Blackburn DF, Dobson RT, Blackburn JL, Wilson TW (2005) Cardiovascular morbidity associated with nonadherence to statin therapy. Pharmacotherapy 25:1035–1043PubMedCrossRef Blackburn DF, Dobson RT, Blackburn JL, Wilson TW (2005) Cardiovascular morbidity associated with nonadherence to statin therapy. Pharmacotherapy 25:1035–1043PubMedCrossRef
79.
Zurück zum Zitat Rasmussen JN, Chong A, Alter DA (2007) Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction. JAMA 297:177–186PubMedCrossRef Rasmussen JN, Chong A, Alter DA (2007) Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction. JAMA 297:177–186PubMedCrossRef
80.
Zurück zum Zitat O’Connor PJ (2006) Improving medication adherence: challenges for physicians, payers, and policy makers. Arch Intern Med 166:1802–1804PubMedCrossRef O’Connor PJ (2006) Improving medication adherence: challenges for physicians, payers, and policy makers. Arch Intern Med 166:1802–1804PubMedCrossRef
81.
Zurück zum Zitat Fonarow GC, Gheorghiade M, Abraham WT (2004) Importance of in-hospital initiation of evidence-based medical therapies for heart failure-a review. Am J Cardiol 94:1155–1160PubMedCrossRef Fonarow GC, Gheorghiade M, Abraham WT (2004) Importance of in-hospital initiation of evidence-based medical therapies for heart failure-a review. Am J Cardiol 94:1155–1160PubMedCrossRef
82.
Zurück zum Zitat Fonarow GC, Abraham WT, Albert NM, Stough WG, Gheorghiade M, Greenberg BH et al (2007) Carvedilol use at discharge in patients hospitalized for heart failure is associated with improved survival: an analysis from organized program to initiate lifesaving treatment in hospitalized patients with heart failure (OPTIMIZE-HF). Am Heart J 153:82–93PubMed Fonarow GC, Abraham WT, Albert NM, Stough WG, Gheorghiade M, Greenberg BH et al (2007) Carvedilol use at discharge in patients hospitalized for heart failure is associated with improved survival: an analysis from organized program to initiate lifesaving treatment in hospitalized patients with heart failure (OPTIMIZE-HF). Am Heart J 153:82–93PubMed
83.
Zurück zum Zitat Krum H, Roecker EB, Mohacsi P, Rouleau JL, Tendera M, Coats AJ et al (2003) Effects of initiating carvedilol in patients with severe chronic heart failure: results from the copernicus study. JAMA 289:712–718PubMedCrossRef Krum H, Roecker EB, Mohacsi P, Rouleau JL, Tendera M, Coats AJ et al (2003) Effects of initiating carvedilol in patients with severe chronic heart failure: results from the copernicus study. JAMA 289:712–718PubMedCrossRef
84.
Zurück zum Zitat Schillinger D, Wang F, Rodriguez M, Bindman A, Machtinger EL (2006) The importance of establishing regimen concordance in preventing medication errors in anticoagulant care. J Health Commun 11:555–567PubMedCrossRef Schillinger D, Wang F, Rodriguez M, Bindman A, Machtinger EL (2006) The importance of establishing regimen concordance in preventing medication errors in anticoagulant care. J Health Commun 11:555–567PubMedCrossRef
85.
Zurück zum Zitat Leape LL, Cullen DJ, Clapp MD, Burdick E, Demonaco HJ, Erickson JI et al (1999) Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. JAMA 282:267–270PubMedCrossRef Leape LL, Cullen DJ, Clapp MD, Burdick E, Demonaco HJ, Erickson JI et al (1999) Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. JAMA 282:267–270PubMedCrossRef
86.
Zurück zum Zitat Lapointe NM, Jollis JG (2003) Medication errors in hospitalized cardiovascular patients. Arch Intern Med 163:1461–1466PubMedCrossRef Lapointe NM, Jollis JG (2003) Medication errors in hospitalized cardiovascular patients. Arch Intern Med 163:1461–1466PubMedCrossRef
87.
Zurück zum Zitat Vansuch M, Naessens JM, Stroebel RJ, Huddleston JM, Williams AR (2006) Effect of discharge instructions on readmission of hospitalised patients with heart failure: do all of the Joint Commission on Accreditation of Healthcare Organizations heart failure core measures reflect better care? Qual Saf Health Care 15:414–417PubMedCrossRef Vansuch M, Naessens JM, Stroebel RJ, Huddleston JM, Williams AR (2006) Effect of discharge instructions on readmission of hospitalised patients with heart failure: do all of the Joint Commission on Accreditation of Healthcare Organizations heart failure core measures reflect better care? Qual Saf Health Care 15:414–417PubMedCrossRef
88.
Zurück zum Zitat Fonarow GC, Abraham WT, Albert NM, Stough WG, Gheorghiade M, Greenberg BH, et al (2007) Association between performance measures and clinical outcomes for patients hospitalized with heart failure. JAMA 297:61–70PubMedCrossRef Fonarow GC, Abraham WT, Albert NM, Stough WG, Gheorghiade M, Greenberg BH, et al (2007) Association between performance measures and clinical outcomes for patients hospitalized with heart failure. JAMA 297:61–70PubMedCrossRef
89.
Zurück zum Zitat Wald NJ, Law MR (2003) A strategy to reduce cardiovascular disease by more than 80%. BMJ 326:1419PubMedCrossRef Wald NJ, Law MR (2003) A strategy to reduce cardiovascular disease by more than 80%. BMJ 326:1419PubMedCrossRef
90.
Zurück zum Zitat Reddy KS (2007) The preventive polypill-much promise, insufficient evidence. N Engl J Med 356:212PubMedCrossRef Reddy KS (2007) The preventive polypill-much promise, insufficient evidence. N Engl J Med 356:212PubMedCrossRef
91.
Zurück zum Zitat Iskedjian M, Einarson TR, Mackeigan LD, Shear N, Addis A, Mittmann N et al (2002) Relationship between daily dose frequency and adherence to antihypertensive pharmacotherapy: evidence from a meta-analysis. Clin Ther 24:302–316PubMedCrossRef Iskedjian M, Einarson TR, Mackeigan LD, Shear N, Addis A, Mittmann N et al (2002) Relationship between daily dose frequency and adherence to antihypertensive pharmacotherapy: evidence from a meta-analysis. Clin Ther 24:302–316PubMedCrossRef
92.
Zurück zum Zitat Schroeder K, Fahey T, Ebrahim S (2004) How can we improve adherence to blood pressure-lowering medication in ambulatory care? systematic review of randomized controlled trials. Arch Intern Med 164:722–732PubMedCrossRef Schroeder K, Fahey T, Ebrahim S (2004) How can we improve adherence to blood pressure-lowering medication in ambulatory care? systematic review of randomized controlled trials. Arch Intern Med 164:722–732PubMedCrossRef
93.
Zurück zum Zitat Giuffrida A, Torgerson DJ (1997) Should we pay the patient? review of financial incentives to enhance patient compliance. BMJ 315:703–707PubMed Giuffrida A, Torgerson DJ (1997) Should we pay the patient? review of financial incentives to enhance patient compliance. BMJ 315:703–707PubMed
94.
Zurück zum Zitat Albert NM (2006) Ring in the new year with care delivery based on pay-for-performance. Prog Cardiovasc Nurs 21:55–56PubMedCrossRef Albert NM (2006) Ring in the new year with care delivery based on pay-for-performance. Prog Cardiovasc Nurs 21:55–56PubMedCrossRef
Metadaten
Titel
Medication adherence in heart failure
verfasst von
Paul J. Hauptman
Publikationsdatum
01.02.2008
Verlag
Springer US
Erschienen in
Heart Failure Reviews / Ausgabe 1/2008
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-007-9020-7

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