Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Calcified Tissue International
Erschienen in: Calcified Tissue International 1/2020

07.04.2020 | Review Article

Medications as a Risk Factor for Fragility Hip Fractures: A Systematic Review and Meta-analysis

verfasst von: Sharri J. Mortensen, Amin Mohamadi, Casey L. Wright, Jimmy J. Chan, Michael J. Weaver, Arvind von Keudell, Ara Nazarian

Erschienen in: Calcified Tissue International | Ausgabe 1/2020

Einloggen, um Zugang zu erhalten

Abstract

Fragility hip fractures and their associated morbidity and mortality pose a global healthcare problem. Several pharmaceutical products have been postulated to alter bone architecture and contribute to fragility hip fractures. We searched four electronic databases from inception to September 2017. Inclusion criteria were the following: (1) adult patients with fragility hip fractures, (2) full text in English, (3) minimum one-year follow-up, and (4) reporting of at least one risk factor. To minimize heterogeneity among the studies, we performed subgroup analyses. Whenever heterogeneity remained significant, we employed random effect meta-analysis for data pooling. Thirty-eight studies were included, containing 1,244,155 subjects and 188,966 cases of fragility hip fractures. Following medications were significantly associated with fragility hip fractures: Antidepressants (OR 2.07, 95% CI 1.98–2.17), antiparkinsonian drugs (OR 2.21, 95% CI 1.15–4.24), antipsychotic drugs (OR 2.0, 95% CI 1.50–2.66), anxiolytic drugs (OR 1.44, 95% CI 1.19–1.75), benzodiazepines (OR 1.84, 95% CI 1.26–2.69), sedatives (OR 1.33, 95% CI 1.14–1.54), systemic corticosteroids (OR 1.65, 95% CI 1.37–1.99), H2 antagonists (OR 1.21, 95% CI 1.18–1.24), proton pump inhibitors (OR 1.41, 95% CI 1.16–1.71), and thyroid hormone (OR 1.29, 95% CI 1.13–1.47). Hormone replacement therapy with estrogen (HRT) was associated with decreased risk of hip fracture (OR 0.80, 95% CI 0.65–0.98). There are several medications associated with sustaining a fragility hip fracture. Medical interventions should be considered for patients on these medications, including information about osteoporosis and fracture prevention.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Nishimura A, Akeda K, Kato K et al (2014) Osteoporosis, vertebral fractures and mortality in a Japanese rural community. Mod Rheumatol 24(5):840–843PubMedCrossRef
2.
Singer A, Exuzides A, Spangler L et al (2015) Burden of illness for osteoporotic fractures compared with other serious diseases among postmenopausal women in the United States. Mayo Clin Proc 90(1):53–62PubMedCrossRef
3.
Peng EW, Elnikety S, Hatrick NC (2006) Preventing fragility hip fracture in high risk groups: an opportunity missed. Postgrad Med J 82(970):528–531PubMedPubMedCentralCrossRef
4.
5.
Zingmond DS, Melton LJ 3rd, Silverman SL (2004) Increasing hip fracture incidence in California Hispanics, 1983 to 2000. Osteoporos Int 15(8):603–610PubMedCrossRef
6.
7.
Goodkin HP, Kapur J (2003) Responsiveness of status Epilepticus to treatment with Diazepan decreases rapidly as seizure duration increases. Epilepsy Curr 3(1):11–12PubMedPubMedCentralCrossRef
8.
Walker J, Tucker LY, Goodney P et al (2015) Type II endoleak with or without intervention after endovascular aortic aneurysm repair does not change aneurysm-related outcomes despite sac growth. J Vasc Surg 62(3):551–561PubMedPubMedCentralCrossRef
9.
Adachi Y, Shiota E, Matsumata T, Iso Y, Yoh R, Kitano S (1998) Bone mineral density in patients taking H2-receptor antagonist. Calcif Tissue Int 62(4):283–285PubMedCrossRef
10.
11.
Mohamadi A, Chan JJ, Lian J et al (2018) Risk factors and pooled rate of prolonged opioid use following trauma or surgery: a systematic review and meta-(regression) analysis. J Bone Joint Surg Am 100(15):1332–1340PubMedCrossRef
12.
Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101CrossRefPubMed
13.
Abrahamsen B, Eiken P, Prieto-Alhambra D, Eastell R (2016) Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study. BMJ 353:i3365PubMedPubMedCentralCrossRef
14.
Adams AL, Shi JXM, Reynolds K et al (2015) Statins and hip fracture risk in men: a population-based case-control study. Ann Epidemiol 25(11):844–848PubMedCrossRef
15.
Apalset EM, Gjesdal CG, Eide GE, Tell GS (2011) Intake of vitamin K1 and K2 and risk of hip fractures: the Hordaland Health Study. Bone 49(5):990–995PubMedCrossRef
16.
Arbouw MEL, Movig KLL, van Staa TP, Egberts ACG, Souverein PC, de Vries F (2011) Dopaminergic drugs and the risk of hip or femur fracture: a population-based case-control study. Osteoporos Int 22(7):2197–2204PubMedCrossRef
17.
Berry SD, Zhu Y, Choi H, Kiel DP, Zhang Y (2013) Diuretic initiation and the acute risk of hip fracture. Osteoporos Int 24(2):689–695PubMedCrossRef
18.
Chang CM, Wu EC, Chang IS, Lin KM (2008) Benzodiazepine and risk of hip fractures in older people: a nested case-control study in Taiwan. Am J Geriatr Psychiatry 16(8):686–692PubMedCrossRef
19.
Chiu HF, Huang YW, Chang CC, Yang CY (2010) Use of proton pump inhibitors increased the risk of hip fracture: a population-based case-control study. Pharmacoepidemiol Drug Saf 19(11):1131–1136PubMedCrossRef
20.
Corley DA, Kubo A, Zhao W, Quesenberry C (2010) Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. Gastroenterology 139(1):93–101PubMedCrossRef
21.
Feskanich D, Willett WC, Stampfer MJ, Colditz GA (1997) A prospective study of thiazide use and fractures in women. Osteoporos Int 7(1):79–84PubMedCrossRef
22.
Fitzpatrick P, Kirke PN, Daly L et al (2001) Predictors of first hip fracture and mortality post fracture in older women. Ir J Med Sci 170(1):49–53PubMedCrossRef
23.
Fox KM, Cummings SR, Williams E, Stone K (2000) Femoral neck and intertrochanteric fractures have different risk factors: a prospective study. Osteoporos Int. 11(12):1018–1023PubMedCrossRef
24.
Grisso JA, Kelsey JL, O'Brien LA et al (1997) Risk factors for hip fracture in men. Hip Fracture Study Group. Am J Epidemiol 145(9):786–793PubMedCrossRef
25.
Hoidrup S, Gronbaek M, Pedersen AT, Lauritzen JB, Gottschau A, Schroll M (1999) Hormone replacement therapy and hip fracture risk: effect modification by tobacco smoking, alcohol intake, physical activity, and body mass index. Am J Epidemiol 150(10):1085–1093PubMedCrossRef
26.
Heidrich FE, Stergachis A, Gross KM (1991) Diuretic drug use and the risk for hip fracture. Ann Intern Med 115(1):1–6PubMedCrossRef
27.
Hugenholtz GW, Heerdink ER, van Staa TP, Nolen WA, Egberts AC (2005) Risk of hip/femur fractures in patients using antipsychotics. Bone 37(6):864–870PubMedCrossRef
28.
Hwang HF, Lee HD, Huang HH, Chen CY, Lin MR (2011) Fall mechanisms, bone strength, and hip fractures in elderly men and women in Taiwan. Osteoporos Int 22(8):2385–2393PubMedCrossRef
29.
Jacqmin-Gadda H, Fourrier A, Commenges D, Dartigues JF (1998) Risk factors for fractures in the elderly. Epidemiology 9(4):417–423PubMedCrossRef
30.
Johnson RE, Specht EE (1981) The risk of hip fracture in postmenopausal females with or without estrogen drug exposure. Am J Public Health 71(2):138–144PubMedPubMedCentralCrossRef
31.
Karakatsani A, Katsoulis M, Klinaki E, Trichopoulou A (2017) Corticosteroids and hip fracture risk in elderly respiratory patients: EPIC-Greece cohort. Adv Respir Med 85(1):22–27PubMedCrossRef
32.
Pierfitte C, Macouillard G, Thicoipe M et al (2001) Benzodiazepines and hip fractures in elderly people: case-control study. BMJ 322(7288):704–708PubMedPubMedCentralCrossRef
33.
Pouwels S, van Staa TP, Egberts AC, Leufkens HG, Cooper C, de Vries F (2009) Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study. Osteoporos Int 20(9):1499–1506PubMedPubMedCentralCrossRef
34.
Pouwels S, Lalmohamed A, Souverein P et al (2011) Use of proton pump inhibitors and risk of hip/femur fracture: a population-based case-control study. Osteoporos Int 22(3):903–910PubMedCrossRef
35.
Rejnmark L, Olsen ML, Johnsen SP, Vestergaard P, Sorensen HT, Mosekilde L (2004) Hip fracture risk in statin users–a population-based Danish case-control study. Osteoporos Int 15(6):452–458PubMedCrossRef
36.
Rejnmark L, Vestergaard P, Mosekilde L (2005) Reduced fracture risk in users of thiazide diuretics. Calcif Tissue Int 76(3):167–175PubMedCrossRef
37.
Rejnmark L, Vestergaard P, Mosekilde L (2006) Fracture risk in patients treated with loop diuretics. J Intern Med 259(1):117–124PubMedCrossRef
38.
Robbins J, Aragaki AK, Kooperberg C et al (2007) Factors associated with 5-year risk of hip fracture in postmenopausal women. JAMA 298(20):2389–2398PubMedCrossRef
39.
Suissa S, Baltzan M, Kremer R, Ernst P (2004) Inhaled and nasal corticosteroid use and the risk of fracture. Am J Respir Crit Care Med 169(1):83–88PubMedCrossRef
40.
Thaler HW, Sterke CS, van der Cammen TJM (2016) Association of proton pump inhibitor use with recurrent falls and risk of fractures in older women: a study of medication use in older fallers. J Nutr Health Aging 20(1):77–81PubMedCrossRef
41.
Tromp AM, Ooms ME, Popp-Snijders C, Roos JC, Lips P (2000) Predictors of fractures in elderly women. Osteoporos Int 11(2):134–140PubMedCrossRef
42.
Vestergaard P, Olsen ML, Paaske Johnsen S, Rejnmark L, Sorensen HT, Mosekilde L (2003) Corticosteroid use and risk of hip fracture: a population-based case-control study in Denmark. J Intern Med 254(5):486–493PubMedCrossRef
43.
Vestergaard P, Rejnmark L, Mosekilde L (2006) Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture. Osteoporos Int 17(6):807–816PubMedCrossRef
44.
Vestergaard P, Rejnmark L, Mosekilde L (2007) Fracture risk associated with parkinsonism and anti-Parkinson drugs. Calcif Tissue Int 81(3):153–161PubMedCrossRef
45.
Wang PS, Solomon DH, Mogun H, Avorn J (2000) HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. JAMA 283(24):3211–3216PubMedCrossRef
46.
Ward IM, Mortensen EM, Battafarano DF, Frei CR, Mansi I (2014) Association of statins and risk of fractures in a military health system: a propensity score-matched analysis. Ann Pharmacother 48(11):1406–1414PubMedCrossRef
47.
Weiland SK, Rückmann A, Keil U, Lewis M, Dennler HJ, Welzel D (1997) Thiazide diuretics and the risk of hip fracture among 70–79 year old women treated for hypertension. Eur J Pub Health 7(3):335–340CrossRef
48.
Yang YX, Lewis JD, Epstein S, Metz DC (2006) Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA J Am Med Assoc 296(24):2947–2953CrossRef
49.
Yu EW, Blackwell T, Ensrud KE et al (2008) Acid-suppressive medications and risk of bone loss and fracture in older adults. Calcif Tissue Int 83(4):251–259PubMedPubMedCentralCrossRef
50.
Van Den Eeden SK, Barzilay JI, Ettinger B, Minkoff J (2003) Thyroid hormone use and the risk of hip fracture in women %3e or = 65 years: a case-control study. J Women's Health 12(1):27–31CrossRef
51.
Jackson JW, Schneeweiss S, VanderWeele TJ, Blacker D (2014) Quantifying the role of adverse events in the mortality difference between first and second-generation antipsychotics in older adults: systematic review and meta-synthesis. PLoS ONE 9(8):e105376PubMedPubMedCentralCrossRef
52.
Nielsen J, Correll CU, Manu P, Kane JM (2013) Termination of clozapine treatment due to medical reasons: when is it warranted and how can it be avoided? J Clin Psychiatry. 74(6):603–613PubMedCrossRef
53.
Stubbs B (2009) Antipsychotic-induced hyperprolactinaemia in patients with schizophrenia: considerations in relation to bone mineral density. J Psychiatr Ment Health Nurs 16(9):838–842PubMedCrossRef
54.
Milovanovic DR, Stanojevic Pirkovic M, Zivancevic Simonovic S et al (2016) Parameters of calcium metabolism fluctuated during initiation or changing of antipsychotic drugs. Psychiatry Investig 13(1):89–101PubMedCrossRef
55.
Cai D, Feng W, Jiang Q (2015) Acid-suppressive medications and risk of fracture: an updated meta-analysis. Int J Clin Exp Med 8(6):8893–8904PubMedPubMedCentral
56.
Cea-Soriano L, Johansson S, Garcia Rodriguez LA (2013) Risk factors for falls with use of acid-suppressive drugs. Epidemiology 24(4):600–607PubMedCrossRef
57.
58.
Xiao X, Xu Y, Wu Q (2018) Thiazide diuretic usage and risk of fracture: a meta-analysis of cohort studies. Osteoporos Int 29(7):1515–1524PubMedCrossRef
59.
Duarte CG, Winnacker JL, Becker KL, Pace A (1971) Thiazide-induced hypercalcemia. N Engl J Med 284(15):828–830PubMedCrossRef
60.
Arnett TR, Spowage M (1996) Modulation of the resorptive activity of rat osteoclasts by small changes in extracellular pH near the physiological range. Bone 18(3):277–279PubMedCrossRef
61.
Peh CA, Horowitz M, Wishart JM, Need AG, Morris HA, Nordin BE (1993) The effect of chlorothiazide on bone-related biochemical variables in normal post-menopausal women. J Am Geriatr Soc 41(5):513–516PubMedCrossRef
62.
Lajeunesse D, Delalandre A, Guggino SE (2000) Thiazide diuretics affect osteocalcin production in human osteoblasts at the transcription level without affecting vitamin D3 receptors. J Bone Miner Res 15(5):894–901PubMedCrossRef
63.
Aubin R, Menard P, Lajeunesse D (1996) Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int 50(5):1476–1482PubMedCrossRef
64.
Jenkinson T, Bhalla AK (1993) A reappraisal of steroid-induced osteoporosis. Br J Hosp Med 50(8):472–476PubMed
65.
Adachi JD, Papaioannou A (2001) Corticosteroid-Induced osteoporosis: detection and management. Drug Saf 24(8):607–624PubMedCrossRef
66.
McKenzie R, Reynolds JC, O'Fallon A et al (2000) Decreased bone mineral density during low dose glucocorticoid administration in a randomized, placebo controlled trial. J Rheumatol 27(9):2222–2226PubMed
67.
Canaris GJ, Manowitz NR, Mayor G, Ridgway EC (2000) The Colorado thyroid disease prevalence study. Arch Intern Med 160(4):526–534PubMedCrossRef
68.
Murphy E, Williams GR (2004) The thyroid and the skeleton. Clin Endocrinol 61(3):285–298CrossRef
69.
Carbone LD, Tylavsky FA, Cauley JA et al (2003) Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivity. J Bone Miner Res 18(10):1795–1802PubMedCrossRef
70.
Bauer DC, Orwoll ES, Fox KM et al (1996) Aspirin and NSAID use in older women: effect on bone mineral density and fracture risk. Study of Osteoporotic Fractures Research Group. J Bone Miner Res 11(1):29–35PubMedCrossRef
71.
Vestergaard P, Hermann P, Jensen JE, Eiken P, Mosekilde L (2012) Effects of paracetamol, non-steroidal anti-inflammatory drugs, acetylsalicylic acid, and opioids on bone mineral density and risk of fracture: results of the Danish Osteoporosis Prevention Study (DOPS). Osteoporos Int 23(4):1255–1265PubMedCrossRef
72.
Hughes JM, McKinnon CJ, Taylor KM et al (2019) Nonsteroidal anti-inflammatory drug prescriptions are associated with increased stress fracture diagnosis in the US army population. J Bone Miner Res 34(3):429–436PubMedCrossRef
73.
74.
Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19(4):385–397PubMedPubMedCentralCrossRef
75.
76.
Sylvester FA (2005) IBD and skeletal health: children are not small adults! Inflamm Bowel Dis 11(11):1020–1023PubMedCrossRef
77.
Ferrari S, Bianchi ML, Eisman JA et al (2012) Osteoporosis in young adults: pathophysiology, diagnosis, and management. Osteoporos Int 23(12):2735–2748PubMedCrossRef
Metadaten
Titel
Medications as a Risk Factor for Fragility Hip Fractures: A Systematic Review and Meta-analysis
verfasst von
Sharri J. Mortensen
Amin Mohamadi
Casey L. Wright
Jimmy J. Chan
Michael J. Weaver
Arvind von Keudell
Ara Nazarian
Publikationsdatum
07.04.2020
Verlag
Springer US
Erschienen in
Calcified Tissue International / Ausgabe 1/2020
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-020-00688-1

Weitere Artikel der Ausgabe 1/2020

Calcified Tissue International 1/2020 Zur Ausgabe

Original Research

The lncRNA GAS5 Inhibits the Osteogenic Differentiation and Calcification of Human Vascular Smooth Muscle Cells

Original Research

Characterization of Skeletal Muscle Endocrine Control in an In Vitro Model of Myogenesis

Original Research

Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene

Original Research

Are Bisphosphonates Associated with Adverse Metabolic and Cognitive Effects? A Study in Intact Rats and Rat-Fed High-Fat High-Fructose Diet

Case Reports

A Case of a Heterozygous Inactivating CASR Variant with Adult-Onset Symptomatic Hypercalcemia Requiring Extensive Surgery

Original Research

Glucocorticoids Enhanced Osteoclast Autophagy Through the PI3K/Akt/mTOR Signaling Pathway

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 | Hypertonie | Nachrichten

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 | Nierenkarzinom | Nachrichten

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 | NSCLC | Nachrichten

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC
weitere anzeigen

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise