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Advances in Gerontology

Erschienen in:

01.01.2019

Melatonin and the Aging Process in Men in the European Part of the Arctic Zone of Russia

verfasst von: L. B. Kim, A. N. Putyatina, G. S. Russkikh, O. B. Tsypysheva

Erschienen in: Advances in Gerontology | Ausgabe 1/2019

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Abstract

We analyzed the concentrations of 6-sulfatoxymelatonin (6-SMT) in working-age men (aged 19–69 years) living in the European part of the Arctic zone of Russia. The 6-SMT level in the studied group was similar to that in the control group of men living in Western Siberia. The 6-SMT level decreased with age and reached the minimal values at the age of 40–49 years. In the group aged 60–69 years, there was a tendency to increase; however, the difference was not statistically significant (p > 0.05) as compared with men aged <29 years. We observed the effect of alcohol use on the 6-SMT level; it was lower in men who consumed alcohol than in nonconsumers. The plasma level of free testosterone decreased with age; this value in the group aged 60–69 years was 50% lower than in the group aged 29 years. We observed the activation of lipid peroxidation, which was not compensated for by a higher activity rate of glutathione-reductase or higher plasma levels of SH groups as compared with the control group. Age-related decrease in the level of melatonin, which is an endogenous antioxidant, was associated with a gradual accumulation of peroxidation products and reduced activity of the antioxidant system due to decreasing level of SH-groups.

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Titel: Melatonin and the Aging Process in Men in the European Part of the Arctic Zone of Russia
verfasst von: L. B. Kim
A. N. Putyatina
G. S. Russkikh
O. B. Tsypysheva
Publikationsdatum: 01.01.2019
Verlag: Pleiades Publishing
Erschienen in: Advances in Gerontology / Ausgabe 1/2019
Print ISSN: 2079-0570
Elektronische ISSN: 2079-0589
DOI: https://doi.org/10.1134/S2079057019010090

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