01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Metastatic polyp of the gallbladder from renal cell carcinoma
- Zeitschrift:
- BMC Cancer > Ausgabe 1/2017
Background
Methods
Results
Sex,
n = 40
|
|
---|---|
Male
|
25 (63%)
|
Female
|
15 (37%)
|
Age, y/o,
n = 39
|
|
Median (range)
|
62 (39 – 80)
|
Mean
’s
|
61 ± 12
|
Laterality of primary RCC,
n = 42
|
|
Right
|
24 (57%)
|
Left
|
18 (43%)
|
Size of primary RCC, cm,
n = 20
|
|
Median (range)
|
7.8 (0.4 – 12.2)
|
Mean ± SD
|
7.2 ± 3.3
|
Timing of gallbladder metastasis,
n = 48
|
|
Synchromous
|
12 (25%)
|
Metachronous
|
36 (75%)
|
Interval of metachronous metastasis, month,
n = 33
|
|
Median (range)
|
60 (1 – 324)
|
Mean ± SD
|
79.4 ± 58.2
|
Symptoms,
n = 43
|
|
No
|
30 (70%)
|
Epigastric pain
|
10 (23%)
|
Nausea or vomiting
|
4 (9%)
|
Epigastric fullness
|
3 (7%)
|
Body weight loss
|
2 (5%)
|
Jaundice
|
1 (2%)
|
Duration of symptom, month,
n = 37
|
|
Median (range)
|
0 (0 – 6)
|
Mean ± SD
|
0.3 ± 1.0
|
Diagnosis method
|
|
Sonography,
n = 42
|
39 (92.9%)
|
CT scan,
n = 44
|
35 (79.5%)
|
MRI,
n = 39
|
8 (20.5%)
|
Preoperative diagnosis,
n = 41
|
|
Gallbladder metastasis from RCC
|
18 (44%)
|
Gallbladder polyp
|
11 (27%)
|
Gallbladder cancer
|
7 (17%)
|
Acute cholecystitis
|
3 (7%)
|
Gallstone
|
2 (5%)
|
Size of metastatic RCC to gallbladder, cm,
n = 40
|
|
Median (range)
|
2.6 (0.8 – 9)
|
Mean ± SD
|
2.9 ± 1.8
|
Vascularity of metastatic RCC to gallbladder,
n = 27
|
|
Hypervascular
|
22 (82%)
|
Heterogenous
|
5 (18%)
|
Location of metastatic RCC in gallbladder,
n = 42
|
|
Fundus
|
20 (48%)
|
Body
|
17 (40%)
|
Neck
|
5 (12%)
|
Appearance of metastatic RCC in gallbladder,
n = 42
|
|
Polypoid mass with narrow stalk to gallbladder
|
38 (91%)
|
Polypoid mass with wide base to gallbladder
|
4 (9%)
|
Presence of gallbladder stone,
n = 39
|
|
No
|
28 (72%)
|
Yes
|
11 (28%)
|
Concomitant multiple metastasis,
n = 47
|
13 (28%)
|
Contralateral kidney
|
6 (13%)
|
Lung
|
6 (13%)
|
Bone
|
3 (6%)
|
Adrenal
|
2 (4%)
|
Pancreas
|
1 (2%)
|
Median (range)
|
1 year survival
|
3 year survival
|
5 year survival
|
P value
|
|
---|---|---|---|---|---|
Mean ± SD, month
|
|||||
Overall,
n = 26
|
26.5 (1 – 132)
|
91.5%
|
76.2%
|
59.3%
|
|
35.3 ± 31.4
|
|||||
Gallbladder metastasis
|
0.333
|
||||
Solitary,
n = 15
|
27 (6 – 96)
|
93.3%
|
80.0%
|
80.0%
|
|
40.6 ± 26.4
|
|||||
Combined with other site metastasis,
n = 11
|
12 (1 – 132)
|
87.5%
|
70.0%
|
23.3%
|
|
28.1 ± 37.4
|
|||||
Gall stone
|
0.831
|
||||
Without,
n = 15
|
24 (1 – 96)
|
92.3%
|
76.9%
|
46.2%
|
|
30.4 ± 25.9
|
|||||
With,
n = 6
|
26 (6 – 47)
|
100%
|
66.7%
|
66.7%
|
|
25.5 ± 15.1
|
|||||
Symptom
|
0.317
|
||||
Without,
n = 19
|
26 (1 – 132)
|
94.4%
|
84.0%
|
60.0%
|
|
36.9 ± 32.0
|
|||||
With,
n = 6
|
18.5 (3 – 96)
|
75.0%
|
50.0%
|
50.0%
|
|
31.5 ± 36.0
|
|||||
Timing of metastasis
|
0.325
|
||||
Synchronous,
n = 8
|
25 (1 – 132)
|
85.7%
|
85.7%
|
85.7%
|
|
38 ± 42.1
|
|||||
Metachronous,
n = 17
|
27 (3 – 96)
|
93.3%
|
70.0%
|
46.7%
|
|
33.4 ± 27.4
|
|||||
Tumor size
|
0.607
|
||||
≤ 2 cm,
n = 9
|
37 (6 – 132)
|
88.9%
|
74.1%
|
44.4%
|
|
42.4 ± 37.7
|
|||||
> 2 cm,
n = 16
|
24 (1 – 96)
|
92.3%
|
76.9%
|
76.9%
|
|
31.9 ± 29.0
|
|||||
Cholecystectomy
|
0.398
|
||||
Open,
n = 23
|
27 (1 – 132)
|
90.5%
|
74.0%
|
55.5%
|
|
37.1 ± 32.4
|
|||||
Laparoscopic,
n = 3
|
12 (6 – 47)
|
100%
|
100%
|
100%
|
|
21.7 ± 22.1
|