Erschienen in:
01.12.2000 | Paper Report
MHC class I upregulation and myositis
verfasst von:
Marina Botto
Erschienen in:
Arthritis Research & Therapy
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Ausgabe 1/2000
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Excerpt
In many human inflammatory myopathies (eg polymyositis and dermatomyositis) the widespread expression of MHC class I molecules on the surface of muscle cells preceeds the inflammatory condition. Although there is no consistent correlation, MHC class I molecules can be upregulated in response to pro-inflammatory cytokines, even though they are rarely expressed on skeletal muscle cells. In addition, the overexpression of MHC class I molecules in several different tissues can cause the destruction of the targeted tissue. To investigate whether the prolonged expression of MHC class I molecules on the surface of muscle cells could be sufficient to cause the development of myositis. …