Erschienen in:
01.12.2001 | Paper Report
Suppression of ERK cascade by scaffold protein JSAP1
verfasst von:
Allan Sudlow
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
The mitogen activated protein (MAP) kinase (MAPK) signalling pathway is an intracellular cascade, identified in organisms from yeast to mammals, consisting primarily of three components (MAPKKK>MAPKK>MAPK). In mammals, five such pathways have so far been identified, including the MEKK (MAP/extracellular signal related kinase [ERK] kinase kinase)-MKK4 (MAPK kinase)/7-c-Jun NH2 terminal kinase (JNK) cascade and Raf-MEK-ERK cascade. These cascades play key roles in many cellular processes, including responses to proinflammatory cytokines and environmental stresses. A family of scaffold proteins has recently emerged which appears to promote specific and efficient activation of these MAPK cascades. The scaffold protein JNK/stress-activated protein kinase-associated protein (JSAP)1 (JIP3) has previously been shown to enhance activation of the JNK pathway by binding its components. In the current study, JSAP1 is now also shown to actively suppress the Raf-MEK-ERK cascade. …
