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Current Rheumatology Reports
Erschienen in: Current Rheumatology Reports 4/2024

01.02.2024 | Research

Microbial Mechanisms of Rheumatoid Arthritis Pathogenesis

verfasst von: Brenda J. Seymour, Brendan E. Allen, Kristine A. Kuhn

Erschienen in: Current Rheumatology Reports | Ausgabe 4/2024

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Abstract

Purpose of Review

Host-microbiome interactions have been implicated in the pathophysiology of rheumatoid arthritis (RA), but the data linking specific microbes to RA is largely associative. Here, we review recent studies that have interrogated specific mechanistic links between microbes and host in the setting of RA.

Recent Findings

Several candidate bacterial species and antigens that may trigger the conversion of an anti-bacterial to an autoimmune response have been recently identified. Additional studies have identified microbial metabolic pathways that are altered in RA. Some of these microbial species and metabolic pathways have been validated in mouse models to induce RA-like immune responses, providing initial evidence of specific mechanisms by which the microbiota contributes to the development of RA.

Summary

Several microbial species, antigens, and metabolites have been identified as potential contributors to RA pathophysiology. Further interrogation and validation of these pathways may identify novel biomarkers of or therapeutic avenues for RA.
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Metadaten
Titel
Microbial Mechanisms of Rheumatoid Arthritis Pathogenesis
verfasst von
Brenda J. Seymour
Brendan E. Allen
Kristine A. Kuhn
Publikationsdatum
01.02.2024
Verlag
Springer US
Erschienen in
Current Rheumatology Reports / Ausgabe 4/2024
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-024-01135-y

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