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Current HIV/AIDS Reports

Erschienen in:

04.11.2021 | HIV Pathogenesis and Treatment (AL Landay and NS Utay, Section Editors)

Microbiome Studies in Non-human Primates

verfasst von: Jason M. Brenchley, Alexandra M. Ortiz

Erschienen in: Current HIV/AIDS Reports | Ausgabe 6/2021

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Abstract

Purpose of Review

Observations of differing bacterial, intestinal microbiomes in people living with HIV have propelled interest in contributions of the microbiome to HIV disease. Non-human primate (NHP) models of HIV infection provide a controlled setting for assessing contributions of the microbiome by standardizing environmental confounders. We provide an overview of the findings of microbiome contributions to aspects of HIV disease derived from these animal models.

Recent Findings

Observations of differing bacterial, intestinal microbiomes are inconsistently observed in the NHP model following SIV infection. Differences in lentiviral susceptibility and vaccine efficacy have been attributed to variations in the intestinal microbiome; however, by-and-large, these differences have not been experimentally assessed.

Summary

Although compelling associations exist, clearly defined contributions of the microbiome to HIV and SIV disease are lacking. The empirical use of comprehensive multi-omics assessments and longitudinal and interventional study designs in NHP models is necessary to define this contribution more clearly.

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Titel: Microbiome Studies in Non-human Primates
verfasst von: Jason M. Brenchley
Alexandra M. Ortiz
Publikationsdatum: 04.11.2021
Verlag: Springer US
Erschienen in: Current HIV/AIDS Reports / Ausgabe 6/2021
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-021-00584-9

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