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Irish Journal of Medical Science (1971 -)

Erschienen in:

05.02.2021 | Original Article

miR-3178 as a prognostic indicator and tumor suppressor of gastric cancer

verfasst von: Jin-cheng Wu, Zhao-hui Liu, Xiaomei Ding, Rui-sheng Ke

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 1/2022

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Abstract

Background

Gastric cancer is a common malignant tumor with an increasing death rate. MicroRNA can serve as a promising biomarker for the progression and prognosis of various cancers.

Aims

The clinical significance and biological function of miR-3178 in gastric cancer was assessed in this study.

Methods

A total of 117 paired tissues were collected from gastric cancer patients. Quantitative real-time polymerase chain reaction was used to detect the expression of miR-3178 in gastric cancer tissues and cells. The association between miR-3178 expression and the clinicopathological features of patients were analyzed by χ² test. Kaplan-Meier analysis and Cox regression were employed to investigate the prognostic value of miR-3178. Finally, the effect of miR-3178 on the cellular process of gastric cancer was investigated by CCK-8 and transwell assay.

Results

miR-3178 was downregulated in gastric cancer tissues and cells, which showed a significant association with the TNM stage and lymph node metastasis of patients and a poor prognosis. MiR-3178 and TNM stage were considered as two independent prognostic factors for gastric cancer. Furthermore, the downregulation of miR-3178 promoted cell proliferation, migration, and invasion of gastric cancer by regulating Notch1.

Conclusion

miR-3178 may be involved in the progression of gastric cancer, which provides new insights into the treatment of gastric cancer.

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Titel: miR-3178 as a prognostic indicator and tumor suppressor of gastric cancer
verfasst von: Jin-cheng Wu
Zhao-hui Liu
Xiaomei Ding
Rui-sheng Ke
Publikationsdatum: 05.02.2021
Verlag: Springer International Publishing
Erschienen in: Irish Journal of Medical Science (1971 -) / Ausgabe 1/2022
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-021-02527-0

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miR-3178 as a prognostic indicator and tumor suppressor of gastric cancer

Abstract

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Aims

Methods

Results

Conclusion

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