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Reproductive Medicine and Biology

Erschienen in:

15.08.2015 | Review Article

Molecular and cellular events involved in the completion of blastocyst implantation

verfasst von: Hiromichi Matsumoto, Emiko Fukui, Midori Yoshizawa

Erschienen in: Reproductive Medicine and Biology | Ausgabe 2/2016

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Abstract

Blastocyst implantation is an interactive process between the embryo and the uterus. The synchronization of embryonic development with uterine differentiation to a receptive state is essential for a successful pregnancy. The period of uterine receptivity for implantation is limited. Although implantation involves the interaction of numerous signaling molecules, our understanding of the hierarchical mechanisms that coordinate with the embryo–uterine dialogue is not yet sufficient to prevent infertility caused by implantation failure. This review highlights our knowledge on uterine receptivity and hormonal regulation of blastocyst implantation in mice. We also discuss the adhesion molecules, cross-linker proteins, extracellular proteins, and matricellular proteins involved in blastocyst implantation. Furthermore, our recent study reveals that selective proteolysis in an activated blastocyst is associated with the completion of blastocyst implantation after embryo transfer. A better understanding of uterine and blastocyst biology during the peri-implantation period would facilitate further development of reproductive technology.

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Titel: Molecular and cellular events involved in the completion of blastocyst implantation
verfasst von: Hiromichi Matsumoto
Emiko Fukui
Midori Yoshizawa
Publikationsdatum: 15.08.2015
Verlag: Springer Japan
Erschienen in: Reproductive Medicine and Biology / Ausgabe 2/2016
Print ISSN: 1445-5781
Elektronische ISSN: 1447-0578
DOI: https://doi.org/10.1007/s12522-015-0222-8

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